Diclofenac (Voltarol)
BASICS: DOSAGE:
• NSAID—Analgesic • 75-150mg daily - t.d.s.
• Also know as voltarol • Voltarol suppository is 100mg
• Inhibits prostaglandin synthesis to reduce
inflammation
• POM
• Tablets or suppository
• Given after perineal repair or caesarean
SIDE EFFECTS: CONTRAINDICATIONS:
• Gastric irritability / Abdo pain • Asthma
• Headache • Pregnancy
• Dizziness • Hypersensitivity to NSAIDs
• Fatigue / Irritability • Cardiac, hepatic or renal impairment
INTERATIONS: • Clotting disorders
• Antihypertensives - increased effect
• Anti-coagulants
PHARMACODYNAMICS: FETAL/BREASTFEEDING RISK:
• Inhibits the enzyme cyclo-oxygenase • Benefits must outweigh the risk and the
which = reduction in prostaglandin lowest possible effective dose should be
synthesis use
• Absorbed through membranes in the anus • Can cause closure of PDA in utero,
and goes straight to systemic circulation persistent pulmonary hypertension
• Eliminated 60% via urine, 40% faeces • The amount secreted too small to be
considered harmful - limited evidence -
manufacturer says toa avoid
BASICS: DOSAGE:
• NSAID—Analgesic • 75-150mg daily - t.d.s.
• Also know as voltarol • Voltarol suppository is 100mg
• Inhibits prostaglandin synthesis to reduce
inflammation
• POM
• Tablets or suppository
• Given after perineal repair or caesarean
SIDE EFFECTS: CONTRAINDICATIONS:
• Gastric irritability / Abdo pain • Asthma
• Headache • Pregnancy
• Dizziness • Hypersensitivity to NSAIDs
• Fatigue / Irritability • Cardiac, hepatic or renal impairment
INTERATIONS: • Clotting disorders
• Antihypertensives - increased effect
• Anti-coagulants
PHARMACODYNAMICS: FETAL/BREASTFEEDING RISK:
• Inhibits the enzyme cyclo-oxygenase • Benefits must outweigh the risk and the
which = reduction in prostaglandin lowest possible effective dose should be
synthesis use
• Absorbed through membranes in the anus • Can cause closure of PDA in utero,
and goes straight to systemic circulation persistent pulmonary hypertension
• Eliminated 60% via urine, 40% faeces • The amount secreted too small to be
considered harmful - limited evidence -
manufacturer says toa avoid
