– Exam #1
THE INSIDER INFORMATION: THE INSIDE SCOOP
Definitions to know:
• Classification
• Prototype
• Generic Name
• Brand Name
• Pharmacodynamics
• Pharmacokinetics
• Half-life
• Onset
• Peak
• Duration
• Agonist
• Antagonist
• Peak
• Trough
• Nursing Process: Assessment, Analysis (Diagnosis), Plan, Implement, Evaluate (Know how this process applies
to the process of medication administration-think like a nurse)
• Anaphylaxis
• Central Nervous System
• Peripheral Nervous System
• Sympathetic Nervous System (Know that adrenaline is really “norepinephrine” and this is the
main neurotransmitter of the SNS)
• Adrenergic (Know that adrenaline is really “norepinephrine” and this is the main neurotransmitter of the SNS)
• Parasympathetic Nervous System (know that acetylcholine is the main neurotransmitter of this system)
• Cholinergic (know that acetylcholine is the main neurotransmitter of this system)
• Competitive inhibition
• Non-competitive inhibition
• Selectivity
• Non-selectivity
• Specificity
• Non-specificity
Know the differences in pharmacokinetics and pharmacodynamics in these populations:
, • Elderly
• Pregnant
• Breastfeeding
• Children and Infants
• Neonates
Medications: For all medications in the table below, know the following (you have already studied :
a. Classification
b. Therapeutic use
c. How does it work (biochemical)
d. Adverse Drug Reactions
e. Interventions
f. Administration
g. Client Instructions
h. Contraindications
i. Precautions
j. Interactions
***For Phenytoin and Lithium, know normal levels
Baclofen (Lioresal) dantrolene sodium (Dantrium) Phenytoin (Dilantin)
Carbamazepine (Tegretol) Valproic Acid (Depakote, Depacon, Gabapentin (Neurontin)
and Depakene)
Lamotrigine (Lamictal) Topiramate (Topamax) Lidocaine (Xylocaine, esters
of this are called Procaine,
Novocain, Benzocain, and
Americaine)
Methohexital sodium Amphetamine/dextroamphetamine Methylphenidate
(Brevital) sulfate (Adderall) (Ritalin/Concerta) and
dexmethylphenidate (Focalin)
Modafinil (Provigil) and Levodopa/Carbidopa (Sinemet) Primapexole (Mirapex
Armodafinil (Nuvigil)
Donepezil (Aricept) and Memantine (Namenda) Interferon beta- 1a (Avonex
rivastigmine (Exelon) and and Rebif) and interferon beta-
alantamine (Razadyne) 1b (Betaseron)
, Sumatriptan (Imitrex) and Diazepam and Lorazepam Buspirone:
zolmitriptan (Zomig) and Clonazepam and
Alprazolam
Amitriptyline (others in this Fluoxetine (Prozac) Others in the Venlafaxine (Effexor XR)
same category are same category: Paroxetine (Paxil), Others in this same category:
imipramine, doxepin, citalopram (Celexa), excitalopram desvenlafaixine (Pristiq) and
protriptyline/Aventyl, (Lexapro), Sertraline (Zoloft) duloxetine (Cympbalta)
amoxapine,
trimipramine/Surmontil)
Phenelzine (Nardil) Others Bupropion hydrochloride (Wellbutrin) Lithium (Lithobid)
in the same category:
isocarboxazid (Marplan),
tranylcypromine (Parnate),
selegiline transdermal
(Emsam)
Valproate and Depakote: Chlorpromazine (Others in this same Risperidone (Risperdal) (Others
category are haloperidol, in this category include
fluphenazine, thiothixene, etc…). olanzapine/Zyprexa, quetiapine
(Seroquel), aripiprazole (Abilify).
Ziprasidone (Geodon),
clozapine
(Clozaril)
Betaxolol (Betopic) Fentanyl (and other opioids:
and Timolol (Timoptic) Morphine, Dilaudid/Hydromorphone,
Oxycodone) Find this in the Neuro
System Part one in ATI under
“anesthesia.
Laboratory Values (know these and be able to interpret them in relation to meds you have learned about)
AST (aspartate aminotransferase) 5-40 units/L
ALT (alanine aminotransferase) 8-20 units/L
Amylase 56-90 IU/L
Lipase 0-110 units/L
Direct (conjugated) bilirubin 0-0.3 mg/dL
Indirect (unconjugated) bilirubin 0.1-1 mg/dL
Phenytoin level 10 to 20 µg/mL
Lithium Level 0.6 to 1.2 mEq/L. Measurement of the serum levels should be carried out at
least 6 to 12 hours after the last therapeutic dose to avoid misinterpretation of
pre-distributional levels
Creatinine The normal range for creatinine in the blood may be 0.84 to 1.21 milligrams
per deciliter (74.3 to 107 micromoles per liter), although this can vary from lab
to lab, between men and women, and by age
Creatinine Clearance Normal values are: Male: 97 to 137 mL/min (1.65 to 2.33 mL/s). Female: 88 to
128 mL/min (14.96 to 2.18 mL/s).
NUR 2474 Pharmacology for Professional Nursing – Examination Blue Print – Exam #2
THE INSIDER INFORMATION: THE INSIDE SCOOP