Question 1
pts
Which of the following pharmacokinetic factors exhibits racial differences?
Absorption.
Passive tubular reabsorption.
Filtration at the glomrulus.
Protein binding.
The pharmacokinetic factors that can be expected to potentially exhibit racial
differences are (1) bioavailability for drugs that undergo gut or hepatic first-pass
metabolism, (2) protein binding, (3) volume of distribution, (4) hepatic metabolism, and
(5) renal tubular secretion. Absorption, filtration at the glomerulus, and passive tubular
reabsorption would not be expected to exhibit such differences.
Question 2
pts
Rifampin is a nonspecific CYP450 inducer that may ?
Cause nonspecific changes in drug metabolism.
Lead to toxic levels of rifampin (Rifadin) and must be monitored closely.
Induce the metabolism of drugs, such as oral contraceptives, leading to therapeutic
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, failure.
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