AP Biology
Free Response
Question
Exercises
, AP Biology Test Booklet
Unit 1 Progress Check: FRQ Name
1. Read each question carefully. Write your response in the space provided for each part of each
question. Answers must be written out in paragraph form. Outlines, bulleted lists, or diagrams
alone are not acceptable and will not be scored.
White blood cells called B cells produce proteins that can be used for the treatment of certain
illnesses. However, these B cells do not live for very long on their own. To keep the B cells
growing for a long time in laboratories, scientists fuse the B cells with cancer cells (fused B-
cancer cells) that do grow for a very long time. The particular cancer cells used for the fusion
are treated with chemicals that make them unable to produce the nitrogenous bases adenine
and guanine, but the B cells with which they are fused do produce these nitrogenous bases.
The scientists grow the large fused B-cancer cells in a growth medium that contains necessary
nutrients for the cells and includes a source of carbon.
(a) Describe the role of carbon in biological systems.
Please respond on separate paper, following directions from your teacher.
(b) The membranes of both B cells and the cancer cells are largely composed of phospholipids.
Explain how, when the membranes are fused, the polar parts of the phospholipids from one
cell will interact with the phospholipids from the other cell and how the nonpolar parts of the
phospholipids from one cell will interact with the phospholipids from the other cell.
Please respond on separate paper, following directions from your teacher.
(c) Make a claim about the most immediate effect on the fused B-cancer cells if the fused cells
are transferred to a growth medium that lacks a source of nitrogen.
Please respond on separate paper, following directions from your teacher.
(d) Provide reasoning with evidence based on the composition of biological macromolecules
to support your claim.
Copyright © 2017. The College Board. These materials are part of a College Board program. Use or distribution of these materials online or in print
beyond your school’s participation in the program is prohibited. Page 1 of 3
, AP Biology Test Booklet
Unit 1 Progress Check: FRQ
Please respond on separate paper, following directions from your teacher.
2. Read each question carefully. Write your response in the space provided for each part of each
question. Answers must be written out in paragraph form. Outlines, bulleted lists, or diagrams
alone are not acceptable and will not be scored.
Scientists are studying the structure and function of Receptor , a single-polypeptide protein
that is found in the membrane around certain types of cells. Receptor contains no alpha-
helices or beta sheets. A specific molecule outside the cells is recognized and bound by
Receptor . The binding of the molecule to Receptor causes the cells to have a particular
response.
To study the structure and function of Receptor , the scientists are altering the sequence of
small sections of the receptor. Both the normal sequence of a five‑amino acid section of
Receptor and an altered sequence that contains two amino acid substitutions are shown in
Figure 1.
Copyright © 2017. The College Board. These materials are part of a College Board program. Use or distribution of these materials online or in print
beyond your school’s participation in the program is prohibited. Page 2 of 3
, AP Biology Test Booklet
Unit 1 Progress Check: FRQ
Figure 1. The normal sequence and the altered sequence of a five-amino acid section
of Receptor
(a) Identify the process used to form the covalent peptide bonds that join amino acids into a
polypeptide.
Please respond on separate paper, following directions from your teacher.
(b) The change in the amino acid sequence illustrated in Figure 1 caused a change in the
shape of Receptor . Based on the groups of the original and substituted amino acids,
explain why Receptor changed shape.
Please respond on separate paper, following directions from your teacher.
(c) Using the template below that represents the four levels of protein structure, place an on
each level that is expected to be altered as a result of the amino acid substitutions shown in
Figure 1.
Please respond on separate paper, following directions from your teacher.
(d) Explain how the amino acid substitution shown in Figure 1 is most likely to affect the
function of Receptor .
Please respond on separate paper, following directions from your teacher.
Copyright © 2017. The College Board. These materials are part of a College Board program. Use or distribution of these materials online or in print beyond your school’s
participation in the program is prohibited. Page 3 of 3
Free Response
Question
Exercises
, AP Biology Test Booklet
Unit 1 Progress Check: FRQ Name
1. Read each question carefully. Write your response in the space provided for each part of each
question. Answers must be written out in paragraph form. Outlines, bulleted lists, or diagrams
alone are not acceptable and will not be scored.
White blood cells called B cells produce proteins that can be used for the treatment of certain
illnesses. However, these B cells do not live for very long on their own. To keep the B cells
growing for a long time in laboratories, scientists fuse the B cells with cancer cells (fused B-
cancer cells) that do grow for a very long time. The particular cancer cells used for the fusion
are treated with chemicals that make them unable to produce the nitrogenous bases adenine
and guanine, but the B cells with which they are fused do produce these nitrogenous bases.
The scientists grow the large fused B-cancer cells in a growth medium that contains necessary
nutrients for the cells and includes a source of carbon.
(a) Describe the role of carbon in biological systems.
Please respond on separate paper, following directions from your teacher.
(b) The membranes of both B cells and the cancer cells are largely composed of phospholipids.
Explain how, when the membranes are fused, the polar parts of the phospholipids from one
cell will interact with the phospholipids from the other cell and how the nonpolar parts of the
phospholipids from one cell will interact with the phospholipids from the other cell.
Please respond on separate paper, following directions from your teacher.
(c) Make a claim about the most immediate effect on the fused B-cancer cells if the fused cells
are transferred to a growth medium that lacks a source of nitrogen.
Please respond on separate paper, following directions from your teacher.
(d) Provide reasoning with evidence based on the composition of biological macromolecules
to support your claim.
Copyright © 2017. The College Board. These materials are part of a College Board program. Use or distribution of these materials online or in print
beyond your school’s participation in the program is prohibited. Page 1 of 3
, AP Biology Test Booklet
Unit 1 Progress Check: FRQ
Please respond on separate paper, following directions from your teacher.
2. Read each question carefully. Write your response in the space provided for each part of each
question. Answers must be written out in paragraph form. Outlines, bulleted lists, or diagrams
alone are not acceptable and will not be scored.
Scientists are studying the structure and function of Receptor , a single-polypeptide protein
that is found in the membrane around certain types of cells. Receptor contains no alpha-
helices or beta sheets. A specific molecule outside the cells is recognized and bound by
Receptor . The binding of the molecule to Receptor causes the cells to have a particular
response.
To study the structure and function of Receptor , the scientists are altering the sequence of
small sections of the receptor. Both the normal sequence of a five‑amino acid section of
Receptor and an altered sequence that contains two amino acid substitutions are shown in
Figure 1.
Copyright © 2017. The College Board. These materials are part of a College Board program. Use or distribution of these materials online or in print
beyond your school’s participation in the program is prohibited. Page 2 of 3
, AP Biology Test Booklet
Unit 1 Progress Check: FRQ
Figure 1. The normal sequence and the altered sequence of a five-amino acid section
of Receptor
(a) Identify the process used to form the covalent peptide bonds that join amino acids into a
polypeptide.
Please respond on separate paper, following directions from your teacher.
(b) The change in the amino acid sequence illustrated in Figure 1 caused a change in the
shape of Receptor . Based on the groups of the original and substituted amino acids,
explain why Receptor changed shape.
Please respond on separate paper, following directions from your teacher.
(c) Using the template below that represents the four levels of protein structure, place an on
each level that is expected to be altered as a result of the amino acid substitutions shown in
Figure 1.
Please respond on separate paper, following directions from your teacher.
(d) Explain how the amino acid substitution shown in Figure 1 is most likely to affect the
function of Receptor .
Please respond on separate paper, following directions from your teacher.
Copyright © 2017. The College Board. These materials are part of a College Board program. Use or distribution of these materials online or in print beyond your school’s
participation in the program is prohibited. Page 3 of 3
