Question 1 of 20
A group of students are reviewing class material in
preparation for a test. The students demonstrate a need
for additional teaching when they identify which of the
following as part of phase I biotransformation?
Conjugation
Hydrolysis
Oxidation
Reduction
Question 2 of 20
A client is receiving 250 mg of a drug that has a half-life of
12 hours. How much drug would remain after 36 hours?
125 mg
16 mg
63 mg
31 mg
Question 3 of 20
The nurse is preparing to administer a prescribed drug to a
client with a history of renal disease. Why should the nurse
anticipate administering a lower dose than for a client with
healthy kidneys?
Distribution will be delayed, increasing the risk of adverse effects.
The client likely has impaired drug metabolism.
Absorption will be increased because of fluid accumulation.
Excretion is likely to take place slowly.
Question 4 of 20
An experienced nurse has observed that female clients
sometimes experience a drug’s eff ects for a longer time
than male clients of similar age and size. The nurse should
attribute this to what factor?
Women have more fat cells so drugs depositing in fat will have a
prolonged effect.
, Men commonly lack certain enzyme systems that are necessary for
metabolizing a drug.
Women more often experience electrolyte imbalances, prolonging
a drug's effect.
Men have more vascular muscle so drug effects will take longer to
occur. Question 5 of 20
A client has developed a tolerance to a drug. How should
the nurse address this when providing care?
Advocate for a change in the client’s medication.
Assess the client for signs and symptoms of adverse drug effects.
Assess the client for signs and symptoms of an allergy to the drug.
Assess whether the client needs larger doses to achieve the effect.
Question 6 of 20
A client is administered an oral contraceptive. What is the
process that occurs between the time the drug enters the
body and the time it enters the bloodstream?
excretion
absorption
distribution
metabolism
Question 7 of 20
Which factor accounts for the increased risk for drug
reactions among clients aged 65 years and older?
drugs more readily crossing the blood–brain barrier in older people
physiologic changes affecting all pharmacokinetic processes
increased drug-metabolizing enzymes in older people
diminished immune response
Question 8 of 20
A 38-year-old client is obese and has abscesses around the
inner thigh muscles. The client is receiving IV antibiotics,
but no improvement has been seen. The client questions
the nurse about the most likely cause for the drug therapy
failure. The nurse explains that the:
, distribution of the drug to the thigh muscles is generally impaired,
even in healthy individuals.
surface area of the abscesses is not large enough for the drug to
have the desired therapeutic effect.
route of administering the medication should not have been IV.
distribution of the drug to the area of the abscesses is impaired.
Question 9 of 20
A 72-year-old man with pain issues is being given a drug
by the intramuscular route. His serum blood level
concentrations have been erratic. The nurse suspects that
this may be due to
decreased gastrointestinal motility.
increased levels of plasma albumin.
decreased blood flow to tissues and muscles.
altered gastric pH levels.
Question 10 of 20
A client will soon be discharged home from the hospital
after a successful coronary artery bypass graft (CABG).
During client education about drug regimen, the nurse
should prioritize teaching about:
the need to have a younger family member oversee drug
administration.
the balance between benefits and risks that underlies the drug
regimen.
potential adverse effects of the drugs that the client will be taking.
the age-related changes that influence the health care provider's
choice of medications.
Question 11 of 20
A nurse is conducting an assessment of a client who has
recently had several changes made to the drug regimen.
What assessment question most directly addresses the
safety implications of the client's drug regimen?
A group of students are reviewing class material in
preparation for a test. The students demonstrate a need
for additional teaching when they identify which of the
following as part of phase I biotransformation?
Conjugation
Hydrolysis
Oxidation
Reduction
Question 2 of 20
A client is receiving 250 mg of a drug that has a half-life of
12 hours. How much drug would remain after 36 hours?
125 mg
16 mg
63 mg
31 mg
Question 3 of 20
The nurse is preparing to administer a prescribed drug to a
client with a history of renal disease. Why should the nurse
anticipate administering a lower dose than for a client with
healthy kidneys?
Distribution will be delayed, increasing the risk of adverse effects.
The client likely has impaired drug metabolism.
Absorption will be increased because of fluid accumulation.
Excretion is likely to take place slowly.
Question 4 of 20
An experienced nurse has observed that female clients
sometimes experience a drug’s eff ects for a longer time
than male clients of similar age and size. The nurse should
attribute this to what factor?
Women have more fat cells so drugs depositing in fat will have a
prolonged effect.
, Men commonly lack certain enzyme systems that are necessary for
metabolizing a drug.
Women more often experience electrolyte imbalances, prolonging
a drug's effect.
Men have more vascular muscle so drug effects will take longer to
occur. Question 5 of 20
A client has developed a tolerance to a drug. How should
the nurse address this when providing care?
Advocate for a change in the client’s medication.
Assess the client for signs and symptoms of adverse drug effects.
Assess the client for signs and symptoms of an allergy to the drug.
Assess whether the client needs larger doses to achieve the effect.
Question 6 of 20
A client is administered an oral contraceptive. What is the
process that occurs between the time the drug enters the
body and the time it enters the bloodstream?
excretion
absorption
distribution
metabolism
Question 7 of 20
Which factor accounts for the increased risk for drug
reactions among clients aged 65 years and older?
drugs more readily crossing the blood–brain barrier in older people
physiologic changes affecting all pharmacokinetic processes
increased drug-metabolizing enzymes in older people
diminished immune response
Question 8 of 20
A 38-year-old client is obese and has abscesses around the
inner thigh muscles. The client is receiving IV antibiotics,
but no improvement has been seen. The client questions
the nurse about the most likely cause for the drug therapy
failure. The nurse explains that the:
, distribution of the drug to the thigh muscles is generally impaired,
even in healthy individuals.
surface area of the abscesses is not large enough for the drug to
have the desired therapeutic effect.
route of administering the medication should not have been IV.
distribution of the drug to the area of the abscesses is impaired.
Question 9 of 20
A 72-year-old man with pain issues is being given a drug
by the intramuscular route. His serum blood level
concentrations have been erratic. The nurse suspects that
this may be due to
decreased gastrointestinal motility.
increased levels of plasma albumin.
decreased blood flow to tissues and muscles.
altered gastric pH levels.
Question 10 of 20
A client will soon be discharged home from the hospital
after a successful coronary artery bypass graft (CABG).
During client education about drug regimen, the nurse
should prioritize teaching about:
the need to have a younger family member oversee drug
administration.
the balance between benefits and risks that underlies the drug
regimen.
potential adverse effects of the drugs that the client will be taking.
the age-related changes that influence the health care provider's
choice of medications.
Question 11 of 20
A nurse is conducting an assessment of a client who has
recently had several changes made to the drug regimen.
What assessment question most directly addresses the
safety implications of the client's drug regimen?
