(Questions and Answers) SSRIs (Selective-Serotonin Reuptake Inhibitors) NCLEX EXAM 2022

1. Which statement below best describes the mechanism of action of how SSRIs work? A. “SSRIs inhibit the reuptake of GABA by blocking the reuptake of serotonin from the pre-synaptic neuron.” B. “SSRIs enhance the reuptake of GABA by amplifying the action of the serotonin receptors found on the post-synaptic neuron.” C. “SSRIs inhibit the reuptake of the neurotransmitter serotonin by the pre-synaptic neuron.” D. “SSRIs enhance the reuptake of serotonin by the receptors on the post-synaptic neuron.” The answer is C. SSRIs (selective serotonin reuptake inhibitors) inhibit the reuptake of the neurotransmitter serotonin by the pre-synaptic neuron. It does this by blocking the serotonin-transporter protein (SERT). 2. The physician determines a patient needs to be started on a selective serotonin reuptake inhibitor (SSRI). As the nurse, you know which medication below is NOT an SSRI? A. Citalopram B Paroxetine C. Fluoxetine D. Rasagiline The answer is D. Rasagiline is a MAOI (monoamine oxidase inhibitor) and is used to treat Parkinson’s Disease.