AGNP Board Exam – Dermatology Prescription Exam
1. Question:
Systemic ivermectin (Stromectol), classified as an antiparasitic,:
is primarily excreted in the urine.
crosses the blood-brain barrier.
has a high concentration in the liver. Correct
is not well absorbed.
Explanation:
Systemic ivermectin (Stromectol) is well absorbed and is primarily excreted in the feces.
It is distributed and highly concentrated in the liver and adipose tissue. It is primarily
bound to albumin, with a half-life elimination of 18 hours. Time to peak serum is about
4 hours.
2. Question:
Topical permethrin (Elimite) in the treatment of scabies should be left in place for a
minimum of:
30 minutes.
2 hours.
6 hours.
8 hours. Correct
Explanation:
Patients should massage permethrin cream (Elimite) thoroughly into the skin from the
neck to the soles of the feet, including areas under the fingernails and toenails. Thirty
grams is usually sufficient for an average adult. The hairline, neck, temples, and
forehead may be infested in infants and geriatric patients. In these populations,
permethrin should also be applied to the scalp and face, sparing the eyes and mouth.
The cream should be removed by washing (shower or bath) after 8 to 14 hours.
3. Question:
The mechanism of action of clindamycin (Cleocin), used in the treatment of cellulitis, is
to:
, block synthesis of folic acid by bacteria and inhibit replication.
uncouple mitochondrial oxidative metabolism and inhibit cell growth.
block the dissociation of peptidyl tRNA from ribosomes.
inhibit protein synthesis by preventing ribosomal translocation. Correct
Explanation:
Sulfa agents block synthesis of folic acid by bacteria and thus inhibit bacterial
replication. First-generation cephalosporins inhibit cell wall synthesis of bacteria.
Antifungals uncouple mitochondrial oxidative metabolism and inhibit cell growth.
Macrolides inhibit bacterial growth, possibly by blocking dissociation of peptidyl tRNA
from ribosomes, causing RNA-dependent protein synthesis to arrest. Other
antibacterials are bacteriostatic or bactericidal and inhibit protein synthesis by
preventing ribosomal translocation.
4. Question:
Tretinoin topical (Retin-A) is indicated for the treatment of acne vulgaris and:
acne rosacea.
dermatomyositis.
inflammatory keratosis pilaris.
mottled hyperpigmentation. Correct
Explanation:
Tretinoin topical (Retin-A) is indicated for the treatment of acne vulgaris, palliation of
fine wrinkles, mottled hyperpigmentation and facial skin roughness.
5. Question:
The brand name of oral isotretinoin is:
Duac.
Absorica. Correct
Accolate.
Accupril.
Explanation:
,The brand names of oral isotretinoin include Absorica, Amnesteem, Claravis, and
Zenatane. The generic name for Duac is clindamycin/benzoyl peroxide, used in the
treatment of acne. The generic name for Accolate is zafirlukast. It is a leukotriene
inhibitor used in the treatment of asthma. The generic name for Accupril is quinapril; it
is an ACE inhibitor.
6. Question:
Benzoyl peroxide (Benzac wash) is classified as a topical:
antibiotic.
astringent.
antimicrobial. Correct
acetic acid-based cleanser.
Explanation:
Benzoyl peroxide is a topical antimicrobial used in the treatment of acne. When applied
to the skin, benzoyl peroxide works by reducing the amount of acne-causing bacteria
and by causing the skin to dry and peel.
7. Question:
The generic name for Elidel is:
permethrin.
pimecrolimus. Correct
tacrolimus.
urea topical.
Explanation:
The generic name for Elidel is pimecrolimus. Elidel is a dermatologic agent used in the
treatment of atopic dermatitis. The brand name of permethrin is Nix or Elimite. It is an
antiparasitic used in the treatment of lice. The brand name for tacrolimus is Prograf. It is
an immunosuppressive drug used after transplant. The brand name of urea topical is
Keralac and it is used in the treatment of hyperkeratosis.
, 8. Question:
Which of the following conditions is NOT a side effect of long-term use of topical
steroids?
Cutaneous atrophy
Glaucoma
Hypotrichosis Correct
Telangiectasia
Explanation:
Cutaneous and systemic side effects can occur, particularly with super potent and
potent drugs, or extensive use of lower potency agents with or without occlusion.
Treatment with topical corticosteroids should be restricted to the lowest and shortest
duration of therapy required to achieve the desired effect. Cutaneous atrophy,
telangiectasia, hypertrichosis, striae, purpura, hypopigmentation, glaucoma, and
suppression of the hypothalamic-pituitary axis are side effects that may occur with
topical corticosteroid use.
9. Question:
Patients using fluorouracil (Carac) for the treatment of actinic keratosis should be
advised to expect:
hypopigmentation.
eczema.
pustular formation.
vesiculation. Correct
Explanation:
When fluorouracil (Carac) is applied to a lesion, erythema followed by vesiculation,
desquamation, erosion and re-epithelialization occurs. Local reactions and alterations in
skin appearance may persist for several weeks after discontinuation.
10. Question:
Tetracycline (Sumycin) is used in the treatment of skin and skin structure infections
caused by:
1. Question:
Systemic ivermectin (Stromectol), classified as an antiparasitic,:
is primarily excreted in the urine.
crosses the blood-brain barrier.
has a high concentration in the liver. Correct
is not well absorbed.
Explanation:
Systemic ivermectin (Stromectol) is well absorbed and is primarily excreted in the feces.
It is distributed and highly concentrated in the liver and adipose tissue. It is primarily
bound to albumin, with a half-life elimination of 18 hours. Time to peak serum is about
4 hours.
2. Question:
Topical permethrin (Elimite) in the treatment of scabies should be left in place for a
minimum of:
30 minutes.
2 hours.
6 hours.
8 hours. Correct
Explanation:
Patients should massage permethrin cream (Elimite) thoroughly into the skin from the
neck to the soles of the feet, including areas under the fingernails and toenails. Thirty
grams is usually sufficient for an average adult. The hairline, neck, temples, and
forehead may be infested in infants and geriatric patients. In these populations,
permethrin should also be applied to the scalp and face, sparing the eyes and mouth.
The cream should be removed by washing (shower or bath) after 8 to 14 hours.
3. Question:
The mechanism of action of clindamycin (Cleocin), used in the treatment of cellulitis, is
to:
, block synthesis of folic acid by bacteria and inhibit replication.
uncouple mitochondrial oxidative metabolism and inhibit cell growth.
block the dissociation of peptidyl tRNA from ribosomes.
inhibit protein synthesis by preventing ribosomal translocation. Correct
Explanation:
Sulfa agents block synthesis of folic acid by bacteria and thus inhibit bacterial
replication. First-generation cephalosporins inhibit cell wall synthesis of bacteria.
Antifungals uncouple mitochondrial oxidative metabolism and inhibit cell growth.
Macrolides inhibit bacterial growth, possibly by blocking dissociation of peptidyl tRNA
from ribosomes, causing RNA-dependent protein synthesis to arrest. Other
antibacterials are bacteriostatic or bactericidal and inhibit protein synthesis by
preventing ribosomal translocation.
4. Question:
Tretinoin topical (Retin-A) is indicated for the treatment of acne vulgaris and:
acne rosacea.
dermatomyositis.
inflammatory keratosis pilaris.
mottled hyperpigmentation. Correct
Explanation:
Tretinoin topical (Retin-A) is indicated for the treatment of acne vulgaris, palliation of
fine wrinkles, mottled hyperpigmentation and facial skin roughness.
5. Question:
The brand name of oral isotretinoin is:
Duac.
Absorica. Correct
Accolate.
Accupril.
Explanation:
,The brand names of oral isotretinoin include Absorica, Amnesteem, Claravis, and
Zenatane. The generic name for Duac is clindamycin/benzoyl peroxide, used in the
treatment of acne. The generic name for Accolate is zafirlukast. It is a leukotriene
inhibitor used in the treatment of asthma. The generic name for Accupril is quinapril; it
is an ACE inhibitor.
6. Question:
Benzoyl peroxide (Benzac wash) is classified as a topical:
antibiotic.
astringent.
antimicrobial. Correct
acetic acid-based cleanser.
Explanation:
Benzoyl peroxide is a topical antimicrobial used in the treatment of acne. When applied
to the skin, benzoyl peroxide works by reducing the amount of acne-causing bacteria
and by causing the skin to dry and peel.
7. Question:
The generic name for Elidel is:
permethrin.
pimecrolimus. Correct
tacrolimus.
urea topical.
Explanation:
The generic name for Elidel is pimecrolimus. Elidel is a dermatologic agent used in the
treatment of atopic dermatitis. The brand name of permethrin is Nix or Elimite. It is an
antiparasitic used in the treatment of lice. The brand name for tacrolimus is Prograf. It is
an immunosuppressive drug used after transplant. The brand name of urea topical is
Keralac and it is used in the treatment of hyperkeratosis.
, 8. Question:
Which of the following conditions is NOT a side effect of long-term use of topical
steroids?
Cutaneous atrophy
Glaucoma
Hypotrichosis Correct
Telangiectasia
Explanation:
Cutaneous and systemic side effects can occur, particularly with super potent and
potent drugs, or extensive use of lower potency agents with or without occlusion.
Treatment with topical corticosteroids should be restricted to the lowest and shortest
duration of therapy required to achieve the desired effect. Cutaneous atrophy,
telangiectasia, hypertrichosis, striae, purpura, hypopigmentation, glaucoma, and
suppression of the hypothalamic-pituitary axis are side effects that may occur with
topical corticosteroid use.
9. Question:
Patients using fluorouracil (Carac) for the treatment of actinic keratosis should be
advised to expect:
hypopigmentation.
eczema.
pustular formation.
vesiculation. Correct
Explanation:
When fluorouracil (Carac) is applied to a lesion, erythema followed by vesiculation,
desquamation, erosion and re-epithelialization occurs. Local reactions and alterations in
skin appearance may persist for several weeks after discontinuation.
10. Question:
Tetracycline (Sumycin) is used in the treatment of skin and skin structure infections
caused by:
