pharm-exam-1-flash-cards

Epinephrine Pharm Exam 1
Epinephrine receptors - *alpha- vasoconstriction

*beta- inotropic/chronotropic (increase contractility= increase CO)

Direct acting adrenergic agonist



Epinephrine uses - *anaphylaxis/ anaphylactic shock

*cardiogenic shock

*septic shock (after norepi)

*local anesthesia (vasoconstriction so don't bleed as much)



Epinephrine adverse rxn - Acute pulmonary edema



Norepinephrine receptor - Alpha only (vasoconstriction= increases PVR=
increases BP)

Direct acting adrenergic agonist



Norepinephrine uses - Septic shock



Norepinephrine adverse rxn - *tissue necrosis (due to vasoconstriction if
injected peripherally)

*extravasation (tx with phentolamine)



Isoproterenol receptors - Beta 1 and 2

direct acting adrenergic agonist



Isoproterenol uses - *not often used, replaced by other agents

*hypotension due to bradycardia (increases HR= decreases perpheral
vascular resistance)

, Epinephrine Pharm Exam 1
*Bradyarrhythmias in neonates

*tilt table test



Dopamine receptors - *alpha 1 (in higher dose)

*beta 1 (in lower dose. leading to increased CO)

*D1 and 2 (in all doses. leading to increased renal blood flow)

direct acting adrenergic agonist



Dopamine uses - *replaced by dobutamine

*cardiogenic shock with oliguria (not urinating)

*septic shock



Dobutamine receptors - B1 synthetic

direct acting adrenergic agonist



Dobutamine uses - *cardiogenic shock (less tachycardia than isoproterenol
or dopamine)

*use with IV drip b/c short half life

*short term use b/c tolerance develops



Dobutamine adverse rxn - *atrial fibrillation

*tolerance develops



Fenoldopam receptors - D1 peripherally

direct acting adrenergic agonist