Unit 4 :
Signalling Immunology Cancer
, a) If a mouse is immunized with xenogeneic (human, rabbit, etc.) MHC
molecules, it generates antibodies against many different epitopes present on
the latter, including the epitopes specific to the MHC allele of the donor of
these molecules (‘‘polymorphic epitopes’’), and the species-specific or
‘‘monomorphic’’ epitopes. Both categories of antibodies can be produced by
hybridomas obtained after the immunization. Which of the following category
of antibodies would you use to block the lysis of LCMV infected fibroblasts in
the Doherty–Zinkernagel experiment?
(1) hybridoma-derived antibodies
(2) anti-polymorphic antibodies
(3) anti-monomorphic antibodies
(4) antibodies to the murine (H-2) allospecific determinants.
Signalling Immunology Cancer
, a) If a mouse is immunized with xenogeneic (human, rabbit, etc.) MHC
molecules, it generates antibodies against many different epitopes present on
the latter, including the epitopes specific to the MHC allele of the donor of
these molecules (‘‘polymorphic epitopes’’), and the species-specific or
‘‘monomorphic’’ epitopes. Both categories of antibodies can be produced by
hybridomas obtained after the immunization. Which of the following category
of antibodies would you use to block the lysis of LCMV infected fibroblasts in
the Doherty–Zinkernagel experiment?
(1) hybridoma-derived antibodies
(2) anti-polymorphic antibodies
(3) anti-monomorphic antibodies
(4) antibodies to the murine (H-2) allospecific determinants.
