1. Question : Which disorder is characterized by the formation of abnormal new bone
at an accelerated rate beginning with excessive resorption of spongy
bone?
Student
Answer: Osteomalacia
Paget disease
Osteoporosis
Osteosarcoma
Instructor Paget disease (osteitis deformans) is a state of increased metabolic activity in bone
Explanation: characterized by abnormal and excessive bone remodeling, both resorption and
formation. Chronic accelerated remodeling eventually enlarges and softens the
affected bones.
Question 2 Question : Considering the pathophysiology of osteoporosis, what are the effects
. of extracellular signal regulated kinases (ERKs) and receptor activator
of RANKL on osteoblasts and osteoclasts?
Student Answer:
ERKs increase the life span of osteoclasts and RANKL decreases
the life span of osteoblasts.
ERKs and RANKL increase the life span of osteoclasts and
decrease the life span of osteoblasts.
ERKs and RANKL increase the life span of osteoblasts and
decrease the life span of osteoclasts.
ERKs increase the life span of osteoblasts and RANKL decreases
the life span of osteoclasts.
Instructor In addition to ERKs, RANKL is required for the antiapoptotic and thus longer
Explanation: life span of osteoclasts. These effects increase the life span of osteoclasts
(i.e., longer bone resorbing) and shorten the life span of the bone-forming
cells, or osteoblasts.
Question 3 Question : _____ is the temporary displacement of two bones in which the bone
. surfaces partially lose contact.
Student
Answer: Dislocation
Subluxation
, Malunion
Nonunion
Instructor Dislocation is the temporary displacement of a bone from its normal position in a
Explanation: joint. If the contact between the two surfaces is only partially lost, the injury is called
a subluxation.
Question 4 Question : What is the diagnosis of a person who has tennis elbow characterized
. by tissue degeneration or irritation of the extensor carpi brevis tendon?
Student
Answer: Lateral epicondylitis
Medial tendinitis
Bursitis
Lateral tendinitis
Instructor Lateral epicondylopathy, commonly called tennis elbow, is the result of tissue
Explanation: degeneration or irritation of the extensor carpi radialis brevis tendon at its origin.
Question 5 Question : Which type of osteoporosis would a person develop after having the left
. leg in a cast for 8 weeks to treat a compound displaced fracture of the
tibia and fibula?
Student
Answer: Iatrogenic
Regional
Idiopathic
Osteoblastic
Instructor Classic regional osteoporosis is associated with disuse or immobilization of a limb
Explanation: because of fractures, motor paralysis, or bone or joint inflammation (Figure 42-10).
Question 6 Question : Bone death as a result of osteomyelitis is because of
.
Student Answer:
formation of immune complexes at the site of infection.
localized ischemia.
TNF- and IL-1.