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BIOS 251 Week 4 Case Study-Tissue

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BIOS 251 Week 4 Case Study-Tissue Required Resources Read/review the following resources for this activity: Textbook Weekly Concepts Minimum of 1 scholarly source Scenario/Summary Steven and Brenda had eagerly anticipated the birth of their first child, a boy named Garth. The first year was joyous and Garth grew normally with no apparent problems other than some trauma induced blistering of the skin. By Garth's third birthday, Brenda noticed that his nails showed some deformities. She mentioned this to his pediatrician during his annual physical but since there were no other problems, the physician decided to just watch the condition and to keep a record of what Garth was doing. At four, Garth exhibited thickening of the palms and soles of the feet and gradual loss of the eyebrow hair. His lovely thick eyelashes were also becoming sparse. By age five, hyperhidrosis over the nose and cheeks were observed. Garth was referred to a dermatologist for follow up where he was determined to have a genetic mutation in the plakophilin gene resulting in a condition known as epidermolysis bullosa a form of ectodermal dysplasia. Deliverables Answer the following questions and save your responses in a Microsoft Word document. Provide a scholarly resource in APA format to support your answers. Describe the five different layers of the skin. Describe the four different cell junctions. What is the purpose of the plakophilin gene? How would mutations in the plakophilin gene disrupt cell to cell interactions? How would mutation in the plakophilin gene lead to hyperhidrosis

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Tissue 1




Week 4 Case Study: Tissue

Student Name

Chamberlain University College of Nursing

Anatomy & Physiology 1 with Lab

September 26th, 2021

, Tissue 2


Describe the five different layers of the skin.


The five layers of the skin are known as the epidermis, which is divided further into five

different layers. The layers are stratum corneum, stratum lucidum, spinosum, granulosum, and

stratum basale. All five of these layers contain different characteristics and responsibilities for

the skin.


- Stratum corneum is the most superficial layer and is the one that is visible, so an

individual can see this layer with their eyes. In the article Skin 1: the structure and

functions of the skin by writer Sandra Lawton she states that within this layer it is made

up of dead skin cells that are filled with keratin, a tougher protein (Lawton, 2021). The

components of this layer not having a nucleus or water present make it waterproof.

- In the article previously stated by Sandra Lawton states that Stratum lucidum is the next

layer which contains dead keratinocytes due to the further distance from the surface and

inability for rich blood supply (Lawton, 2021). This is the layer that is most found in

palms of the hands or soles of the feet where the skin is thickest.

- The Spinosum and Granulosum layers are the next layers. In the book Anatomy and

Physiology: Unity of Form and Function by Kenneth Saladin he states that these layers

both contain cells that are spiny-shaped due to having the responsibility of the skin's

strength and flexibility (Saladin, 2019).

- Stratum basale is the deepest layer of skin. This layer is the basal layer which is the

innermost layer of the epidermis. The stratum basale is located near the blood supply

of the dermis and its cells are the only ones capable of mitosis while containing

keratinocytes. This layer moves upwards as the cells age until they have reached the

outermost layer of the skin: the stratum corneum.

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February 21, 2022
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Dr.elizabeth kostal
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