Bone 1
Week 6 Case Study: Bone
Student Name
Chamberlain University College of Nursing
Anatomy & Physiology 1 with Lab
October 10th, 2021
, Bone 2
Describe the bone cells that are involved in the generation of bone tissue.
Osteogenic cells are embryonic mesenchyme-derived stem cells that give rise to most other bone
cell types. They keep multiplying, and some of them develop into the osteoblasts.
Osteoblasts are bone-forming cells that create and stimulate the mineralization of the bone's
organic content. Osteogenesis is the process of making bones. In the endosteum and inner layer
of the periosteum, osteoblasts create rows that resemble a cuboidal epithelium on the bone
surface. Because they are nonmitotic, the osteogenic cells are the only source of new osteoblasts.
Stress and fractures cause those cells to undergo faster mitosis, resulting in a rapid increase in the
number of osteoblasts, which then strengthen or rebuild the bone.
Osteocytes have a variety of purposes. Some resorb bone matrix while others deposit it, assisting
in the homeostatic maintenance of bone density and calcium and phosphate ion concentrations in
the blood. They're also strain sensors, which is perhaps even more significant. This activates the
sensory cilia on osteocytes, causing them to produce signals that control bone remodeling, or
changes in bone structure and density in response to stress.
Osteoclasts are bone-dissolving cells on the bone surfaces. They arise from the same stem cells
in the bone marrow as blood cells. Osteogenic cells, osteoblasts, and osteocytes are all members
of the same cell lineage, while osteoclasts are distinct. The side of the osteoclast that faces the
bone surface has a ruffled border with several deep infoldings of the plasma membrane, which
increases surface area and bone resorption effectiveness. Osteoclasts live in resorption bays,
which they etch into the surface of the bone.
Week 6 Case Study: Bone
Student Name
Chamberlain University College of Nursing
Anatomy & Physiology 1 with Lab
October 10th, 2021
, Bone 2
Describe the bone cells that are involved in the generation of bone tissue.
Osteogenic cells are embryonic mesenchyme-derived stem cells that give rise to most other bone
cell types. They keep multiplying, and some of them develop into the osteoblasts.
Osteoblasts are bone-forming cells that create and stimulate the mineralization of the bone's
organic content. Osteogenesis is the process of making bones. In the endosteum and inner layer
of the periosteum, osteoblasts create rows that resemble a cuboidal epithelium on the bone
surface. Because they are nonmitotic, the osteogenic cells are the only source of new osteoblasts.
Stress and fractures cause those cells to undergo faster mitosis, resulting in a rapid increase in the
number of osteoblasts, which then strengthen or rebuild the bone.
Osteocytes have a variety of purposes. Some resorb bone matrix while others deposit it, assisting
in the homeostatic maintenance of bone density and calcium and phosphate ion concentrations in
the blood. They're also strain sensors, which is perhaps even more significant. This activates the
sensory cilia on osteocytes, causing them to produce signals that control bone remodeling, or
changes in bone structure and density in response to stress.
Osteoclasts are bone-dissolving cells on the bone surfaces. They arise from the same stem cells
in the bone marrow as blood cells. Osteogenic cells, osteoblasts, and osteocytes are all members
of the same cell lineage, while osteoclasts are distinct. The side of the osteoclast that faces the
bone surface has a ruffled border with several deep infoldings of the plasma membrane, which
increases surface area and bone resorption effectiveness. Osteoclasts live in resorption bays,
which they etch into the surface of the bone.
