The Framingham Heart Study—Integrative Exercises
Background
The National Heart, Lung, and Blood Institute (NHLBI)1 created a teaching dataset that
includes real but anonymized data collected as part of the Framingham Heart Study. The Framingham
Heart Study is one of the most influential and longest running epidemiological studies of risk factors
for cardiovascular disease ever run. The study started in 1948 and continues today to collect extensive
data from original participants, their children, and their children’s children. Much of what we know
about cardiovascular disease was discovered by investigators involved in the Framingham Heart Study.
In fact, studies to date using data collected in the Framingham Heart study have resulted in over 3000
m
er as
publications in high impact, peer-reviewed medical journals.
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The Framingham Heart Study has been widely discussed in the media. WGBH in Boston
o.
rs e
produced a video documentary for PBS entitled “The Hidden Epidemic: Heart Disease in America”
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that details the history of heart disease in this country and highlights the Framingham Heart Study.2 In
o
2007, CBS News did a story on the study, its participants, and its impact.3 Additionally, research results
aC s
vi y re
from the Framingham Heart Study are communicated widely, most recently highlighting the discovery
of a gene that may promote obesity4 and new data showing declining rates of dementia.5 Interested
ed d
readers can visit the Framingham Heart Study website for a detailed history of this incredible study and
ar stu
its many contributions to preventive medicine.6
is
Th
Datasets for Analysis
NHLBI created a longitudinal teaching dataset includes clinical, laboratory, and outcome data
sh
on n = 4434 participants. Each participant has between one and three observations—which represent
1 http://www.nhlbi.nih.gov/
2 http://www.pbs.org/wgbh/takeonestep/heart/
3 http://www.cbsnews.com/videos/landmark-heart-study/
4 http://www.cbsnews.com/news/how-a-fat-gene-may-influence-your-weight/
5 http://www.cbsnews.com/news/dementia-alzheimers-risk-signs-of-hope-study/
6 https://www.framinghamheartstudy.org/about-fhs/history.php/
This study source was downloaded by 100000823909754 from CourseHero.com on 04-20-2021 14:13:17 GMT -05:00
1
https://www.coursehero.com/file/62058867/Framington-Case-study-analysis-questions-42520-2docx/
, examinations held approximately 6 years apart. There are a total of 11,627 observations in the full
dataset. A detailed description of the Framingham Heart Study dataset and other public use datasets
available from NHLBI are available on the NHLBI Biologic Specimen and Data Repository
Information Coordinating Center (BioLINCC) website.7
Two datasets are available for analysis here—one is the complete dataset with n = 11,627
observations (or person-exams), and the second includes only data collected at the first examination for
each participant (n = 4434). The two datasets are available as comma separated values (.csv) files for
analysis in Excel, R, or other statistical computing packages. FHS-All.csv contains n = 11,627
observations and FHS-Exam1.csv contains n = 4434 observations.
m
er as
Variables
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The following variables are available in each dataset for analysis (extracted from the complete
o.
rs e
documentation file, available on the NHLBI BioLINCC website 8).
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Variable Name Description Coding Details/Range
RANDID Unique identification number for each participant 2248-9999312
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SEX Participant sex 1 = Male, 2 = Female
aC s
PERIOD Exam cycle 1, 2, 3
vi y re
TIME Number of days since first (baseline) exam 0–4854
AGE Age at exam, years 32–81
SYSBP Systolic blood pressure, mmHg 83–295
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DIABP Diastolic blood pressure, mmHg 30–150
BPMEDS Use of anti-hypertensive medication 0 = No, 1 = Yes
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CURSMOKE Currently smoking cigarettes 0 = No, 1 = Yes
CIGPDAY Number of cigarettes smoked per day 0 (non-smoker)–90
TOTCHOL Total serum cholesterol, mg/dL 107–696
is
HDLC* High density lipoprotein cholesterol, mg/dL 10–189
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LDLC* Low density lipoprotein cholesterol, mg/dL 20–565
BMI Body mass index = weight (kg)/height (m)2 14–57
GLUCOSE Serum glucose, mg/dL 39–478
DIABETES Diabetes (glucose > 200 mg/dL or on treatment) 0 = No, 1 = Yes
sh
HEARTRTE Heart rate, beats/minute 37–220
PREVAP Prevalent angina pectoris 0 = No, 1 = Yes
PREVCHD Prevalent coronary heart disease (CHD) 0 = No, 1 = Yes
PREVMI Prevalent myocardial infarction (MI) 0 = No, 1 = Yes
7 https://biolincc.nhlbi.nih.gov/static/studies/teaching/framdoc.pdf?link_time=2016-07-06_14:21:55.514359
8 https://biolincc.nhlbi.nih.gov/static/studies/teaching/framdoc.pdf?link_time=2016-07-06_14:21:55.514359
This study source was downloaded by 100000823909754 from CourseHero.com on 04-20-2021 14:13:17 GMT -05:00
2
https://www.coursehero.com/file/62058867/Framington-Case-study-analysis-questions-42520-2docx/
Background
The National Heart, Lung, and Blood Institute (NHLBI)1 created a teaching dataset that
includes real but anonymized data collected as part of the Framingham Heart Study. The Framingham
Heart Study is one of the most influential and longest running epidemiological studies of risk factors
for cardiovascular disease ever run. The study started in 1948 and continues today to collect extensive
data from original participants, their children, and their children’s children. Much of what we know
about cardiovascular disease was discovered by investigators involved in the Framingham Heart Study.
In fact, studies to date using data collected in the Framingham Heart study have resulted in over 3000
m
er as
publications in high impact, peer-reviewed medical journals.
co
eH w
The Framingham Heart Study has been widely discussed in the media. WGBH in Boston
o.
rs e
produced a video documentary for PBS entitled “The Hidden Epidemic: Heart Disease in America”
ou urc
that details the history of heart disease in this country and highlights the Framingham Heart Study.2 In
o
2007, CBS News did a story on the study, its participants, and its impact.3 Additionally, research results
aC s
vi y re
from the Framingham Heart Study are communicated widely, most recently highlighting the discovery
of a gene that may promote obesity4 and new data showing declining rates of dementia.5 Interested
ed d
readers can visit the Framingham Heart Study website for a detailed history of this incredible study and
ar stu
its many contributions to preventive medicine.6
is
Th
Datasets for Analysis
NHLBI created a longitudinal teaching dataset includes clinical, laboratory, and outcome data
sh
on n = 4434 participants. Each participant has between one and three observations—which represent
1 http://www.nhlbi.nih.gov/
2 http://www.pbs.org/wgbh/takeonestep/heart/
3 http://www.cbsnews.com/videos/landmark-heart-study/
4 http://www.cbsnews.com/news/how-a-fat-gene-may-influence-your-weight/
5 http://www.cbsnews.com/news/dementia-alzheimers-risk-signs-of-hope-study/
6 https://www.framinghamheartstudy.org/about-fhs/history.php/
This study source was downloaded by 100000823909754 from CourseHero.com on 04-20-2021 14:13:17 GMT -05:00
1
https://www.coursehero.com/file/62058867/Framington-Case-study-analysis-questions-42520-2docx/
, examinations held approximately 6 years apart. There are a total of 11,627 observations in the full
dataset. A detailed description of the Framingham Heart Study dataset and other public use datasets
available from NHLBI are available on the NHLBI Biologic Specimen and Data Repository
Information Coordinating Center (BioLINCC) website.7
Two datasets are available for analysis here—one is the complete dataset with n = 11,627
observations (or person-exams), and the second includes only data collected at the first examination for
each participant (n = 4434). The two datasets are available as comma separated values (.csv) files for
analysis in Excel, R, or other statistical computing packages. FHS-All.csv contains n = 11,627
observations and FHS-Exam1.csv contains n = 4434 observations.
m
er as
Variables
co
eH w
The following variables are available in each dataset for analysis (extracted from the complete
o.
rs e
documentation file, available on the NHLBI BioLINCC website 8).
ou urc
Variable Name Description Coding Details/Range
RANDID Unique identification number for each participant 2248-9999312
o
SEX Participant sex 1 = Male, 2 = Female
aC s
PERIOD Exam cycle 1, 2, 3
vi y re
TIME Number of days since first (baseline) exam 0–4854
AGE Age at exam, years 32–81
SYSBP Systolic blood pressure, mmHg 83–295
ed d
DIABP Diastolic blood pressure, mmHg 30–150
BPMEDS Use of anti-hypertensive medication 0 = No, 1 = Yes
ar stu
CURSMOKE Currently smoking cigarettes 0 = No, 1 = Yes
CIGPDAY Number of cigarettes smoked per day 0 (non-smoker)–90
TOTCHOL Total serum cholesterol, mg/dL 107–696
is
HDLC* High density lipoprotein cholesterol, mg/dL 10–189
Th
LDLC* Low density lipoprotein cholesterol, mg/dL 20–565
BMI Body mass index = weight (kg)/height (m)2 14–57
GLUCOSE Serum glucose, mg/dL 39–478
DIABETES Diabetes (glucose > 200 mg/dL or on treatment) 0 = No, 1 = Yes
sh
HEARTRTE Heart rate, beats/minute 37–220
PREVAP Prevalent angina pectoris 0 = No, 1 = Yes
PREVCHD Prevalent coronary heart disease (CHD) 0 = No, 1 = Yes
PREVMI Prevalent myocardial infarction (MI) 0 = No, 1 = Yes
7 https://biolincc.nhlbi.nih.gov/static/studies/teaching/framdoc.pdf?link_time=2016-07-06_14:21:55.514359
8 https://biolincc.nhlbi.nih.gov/static/studies/teaching/framdoc.pdf?link_time=2016-07-06_14:21:55.514359
This study source was downloaded by 100000823909754 from CourseHero.com on 04-20-2021 14:13:17 GMT -05:00
2
https://www.coursehero.com/file/62058867/Framington-Case-study-analysis-questions-42520-2docx/
