PHM 323 MIDTERM EXAM
Characteristics of drugs that are typically perfusion-limited
- small, lipophilic, water-soluble, and drugs that distribute paracellularly
At equilibrium, Cup ____ Cut (<, =, >)
-=
Protein binding can decrease _______ and increase ______
- glomerular filtration, half-life
When C/Cb << 1.0:
-binding to blood cells is extensive
-lowest limit = 0 (no plasma protein binding)
When C/Cb >> 1.0:
-binding to plasma proteins is extensive
-upper limit is 2 (bc half of the blood is plasma)
Types of drugs excreted by the kidneys
-low MW
-slowly metabolized
Drug enters kidney via the ______ annd leaves partly in the ______ and partly in the ______
-renal artery
-vein
-urine
Characteristics of drugs that are typically perfusion-limited
- small, lipophilic, water-soluble, and drugs that distribute paracellularly
At equilibrium, Cup ____ Cut (<, =, >)
-=
Protein binding can decrease _______ and increase ______
- glomerular filtration, half-life
When C/Cb << 1.0:
-binding to blood cells is extensive
-lowest limit = 0 (no plasma protein binding)
When C/Cb >> 1.0:
-binding to plasma proteins is extensive
-upper limit is 2 (bc half of the blood is plasma)
Types of drugs excreted by the kidneys
-low MW
-slowly metabolized
Drug enters kidney via the ______ annd leaves partly in the ______ and partly in the ______
-renal artery
-vein
-urine
