①wbas Mansour
,Tuesday Heterocycles : :
* Heterocycles are cyclic comp . Contain one
or more hetero atom .
→ More common ENlo es Ip ?
→ less common EBIALIFelsnlcualg.la/SiJ
u
X X 3
IN\
e. hexane
benzene pyrazine .
piperazine
- -
Homo cycles heterocycles
* Note : So heterocycles can be Sat . or
unsat .
* importance :
i . 90k of our drug's body .
2- the most important two are purine and
pyrimidine they build up DNA
.
- .
, "
E-¥ ¥.IN
pyrimidine purine
'
histamine
Note : pyrimidine 1,3
pyrazine 1,4
* the old classification of heterocycles :
i - heterochromatic Cunsat ) .
2- hetero ethylenic (partially sat ) . .
3- heteroparaffinic (sat ) . .
* Aromatic hetatch Concept :
6Fé but not
necessary 3 etou.pk bonds .
F ⇐÷*
6ñé 6ñé
3 douple bonds .
zdouple .
, *
Aromaticity and . : -
cyclic .
6Th e-
single
.
-
conjugation (douple
-
.
-
- resonance .
* Now the new classification depends on physical -
chemical properties which depends on the
Velanee E and their orientation .
ex : benzene + Heo ¥⇐V two phases
pyrimidine -1 Heo one phase .
What happenedis Nchanged the physical -
chemical properties .
Actually functional groups are responsible for the
properties while R is responsible for the value .
in this classification we consider N (the hetero
atom ) as functional group .
,Tuesday Heterocycles : :
* Heterocycles are cyclic comp . Contain one
or more hetero atom .
→ More common ENlo es Ip ?
→ less common EBIALIFelsnlcualg.la/SiJ
u
X X 3
IN\
e. hexane
benzene pyrazine .
piperazine
- -
Homo cycles heterocycles
* Note : So heterocycles can be Sat . or
unsat .
* importance :
i . 90k of our drug's body .
2- the most important two are purine and
pyrimidine they build up DNA
.
- .
, "
E-¥ ¥.IN
pyrimidine purine
'
histamine
Note : pyrimidine 1,3
pyrazine 1,4
* the old classification of heterocycles :
i - heterochromatic Cunsat ) .
2- hetero ethylenic (partially sat ) . .
3- heteroparaffinic (sat ) . .
* Aromatic hetatch Concept :
6Fé but not
necessary 3 etou.pk bonds .
F ⇐÷*
6ñé 6ñé
3 douple bonds .
zdouple .
, *
Aromaticity and . : -
cyclic .
6Th e-
single
.
-
conjugation (douple
-
.
-
- resonance .
* Now the new classification depends on physical -
chemical properties which depends on the
Velanee E and their orientation .
ex : benzene + Heo ¥⇐V two phases
pyrimidine -1 Heo one phase .
What happenedis Nchanged the physical -
chemical properties .
Actually functional groups are responsible for the
properties while R is responsible for the value .
in this classification we consider N (the hetero
atom ) as functional group .
