Androgens (Testerone)
Androgenic/ anabolic Steroids: Testosterone, Testosterone Undecanoate, Testosterone
Propionat, Testosterone Cypionate, Testosterone Enanthate.
Methyltestosterone, Fluoxymesterone, Oxymetholone, Oxandrolone, Metenolone,
Methandienone, Stanozolol, Mesterolone, Nandrolone Decanoate.
Therapeutic Uses:
Androgenic (Androgen replacement therapy, Induction of Male Puberty,
Masculinzing Hormone therapy)
Anabolic (bone marrow stimulation, growth, osteoporosis, aging)
Ergogenic (illicit use) (Abuse in sports) ---- -ve feedback on GnRH
Other: Breast Cancer in women. Postmenopausal and Transgender Women; libido and
quality of life. Postpartum, reduce breast engorgement.
Side effects:
Male Specific: Priapism, gynecomastia, azoospermia, testicular atrophy, prostate
hypertrophy and prostate cancer.
Female Specific: Masculinization, voice deepening, hirsutism, menstrual disturbances, clitoral
enlargement, breast atrophy and uterine atrophy. ------ should be avoided in pregnancy.
Child Specific: Premature epiphyseal closure (short stature), precocious puberty in boys,
delayed puberty and contra-sexual precocity in girl.
General:
Dermatological: Oily skin, acne stretch marks (rapid muscle enlargement), hypertrichosis
(excessive body hair growth), androgenic alopecia and fluid retention edema.
Endocrine: Libido changes, infertility and hypogonadism.
Hepatic: elevated liver function tests and hepatotoxicity: exclusively with 17 - alkylated AAS
such as Methyltestosterone, Oxymetholone.
Cardiovascular: dyslipidemia (increased LDL levels and decreased HDL levels), atherosclerosis,
hypertension, (sodium and water retention) thrombosis, myocardial infarction and sudden
death.
Psychiatric: mood swings, anxiety and cognitive impairment.
, Anti-Androgens:
Androgen 1st gen(nonsteroidal): NSAAs are used for the treatment
receptor Flutamide, Nilutamide, of prostate cancer.
inhibitors Bicalutaminde
Enzalutaminde,
Apalutamide
Cyproterone Acetate Used for treatment of women with
(has progestational hirsutism and in men to decrease
activity that provides excessive sexual drive
negative feedback to
the HPA)
Spironolactone Used in the treatment of hirsutism
(compete with DHT and in women, acne in women and
reduce -hydroxylase androgenic alopecia.
activity)
Androgen Ketoconazole, used in Prostate Cancer.
synthesis Abiraterone (17 -
Inhibitors hydroxylase inhibitors)
DHT synthesis Finasteride, benign prostatic hyperplasia and
inhibitors Dutasteride, Alfatradiol male pattern baldness in men
(inhibit 5-
Androgenic/ anabolic Steroids: Testosterone, Testosterone Undecanoate, Testosterone
Propionat, Testosterone Cypionate, Testosterone Enanthate.
Methyltestosterone, Fluoxymesterone, Oxymetholone, Oxandrolone, Metenolone,
Methandienone, Stanozolol, Mesterolone, Nandrolone Decanoate.
Therapeutic Uses:
Androgenic (Androgen replacement therapy, Induction of Male Puberty,
Masculinzing Hormone therapy)
Anabolic (bone marrow stimulation, growth, osteoporosis, aging)
Ergogenic (illicit use) (Abuse in sports) ---- -ve feedback on GnRH
Other: Breast Cancer in women. Postmenopausal and Transgender Women; libido and
quality of life. Postpartum, reduce breast engorgement.
Side effects:
Male Specific: Priapism, gynecomastia, azoospermia, testicular atrophy, prostate
hypertrophy and prostate cancer.
Female Specific: Masculinization, voice deepening, hirsutism, menstrual disturbances, clitoral
enlargement, breast atrophy and uterine atrophy. ------ should be avoided in pregnancy.
Child Specific: Premature epiphyseal closure (short stature), precocious puberty in boys,
delayed puberty and contra-sexual precocity in girl.
General:
Dermatological: Oily skin, acne stretch marks (rapid muscle enlargement), hypertrichosis
(excessive body hair growth), androgenic alopecia and fluid retention edema.
Endocrine: Libido changes, infertility and hypogonadism.
Hepatic: elevated liver function tests and hepatotoxicity: exclusively with 17 - alkylated AAS
such as Methyltestosterone, Oxymetholone.
Cardiovascular: dyslipidemia (increased LDL levels and decreased HDL levels), atherosclerosis,
hypertension, (sodium and water retention) thrombosis, myocardial infarction and sudden
death.
Psychiatric: mood swings, anxiety and cognitive impairment.
, Anti-Androgens:
Androgen 1st gen(nonsteroidal): NSAAs are used for the treatment
receptor Flutamide, Nilutamide, of prostate cancer.
inhibitors Bicalutaminde
Enzalutaminde,
Apalutamide
Cyproterone Acetate Used for treatment of women with
(has progestational hirsutism and in men to decrease
activity that provides excessive sexual drive
negative feedback to
the HPA)
Spironolactone Used in the treatment of hirsutism
(compete with DHT and in women, acne in women and
reduce -hydroxylase androgenic alopecia.
activity)
Androgen Ketoconazole, used in Prostate Cancer.
synthesis Abiraterone (17 -
Inhibitors hydroxylase inhibitors)
DHT synthesis Finasteride, benign prostatic hyperplasia and
inhibitors Dutasteride, Alfatradiol male pattern baldness in men
(inhibit 5-
