phase 1 Metabolism
University of Jordan
2021 -
2022 .
, Types of oxidation :
222
phase T Metabolism :
- 1. Ar .
Ring Oxidation
d- v. CYP 45°
Ring g phenol .
# ② oxidation : ( most important) →
(e- Rich)
enzymes Resp for Oxidation
. have Different names :
MOA :
1. Mixed function Oxidases o - Oe
-
A""""
~ Slow And Unlike Glucose kinases the can function @n ←
] unstable OH goes t
many sub . 4- 5 hrs After exposure .
H (e- from
the Ring) Ring
H
R
2. Microsomal isoenzymes .
R€
° " "
?
-
in -
it
,
↳ Referees to 7
liver micro -
molecules .
H.philic ✓
↳
isozymes Differentstructures
~ but same a) Oxigen gives
OR
function → we can put them
. into families : R -
g
its electrons
-
Steroidal Aliphatic , Ar Rings
.
~
They can switch
,
H
.
-
philie
Their jobs ~ Do the function slower .
epoxide
-
might be seen in urine
~
.
3. CYP 450 → protein -1 Co - factor .
: gÑl I'D WIN
This cofactor is A heme group = porforin = 4 fused . Para position
-
SIG is! If I -
"
pyroles 1- ferric Fe
"
in the middle . t.si →, Meta W is is
-
IF its
-
↳ chelation .
-
e- Acceptor -
Coordinate borides .
. Ortho JI I
-
Strong
Note : this heme contains ferric Blood heme contains ferriousfe " This's bc CYP 450 is
strictly Oriented .
→ fe→~ 4 coordinates with N from the heme . .
e- Rich -
Ring JI o's n -8 ni § -
1 ( down) with Midazole from the protein "
~ histidine a. a. ex :
¥ -1
¥ it Ñ
'
1 ( up) with Oz ( source for Oxidation) .
r⇐→⑦ N
-
Deficient .
CL
H
~
why called eyp 450 P .
Clonidine d If É
bc it produces the Red cellular dye upon exposure
To .c=o .
Radical -
gives A Peak At ✗ = 45° '
Moderate speed -
half conj in ← Yeild 50%
Note : glucorinic Acid -
has carboxylic Acid ← vrin ,
half uncharged .
functional group → Anionic Active Transport
~ from plasma to urine ~
After 24 hrs half of the molecules would
in Another word conj . half get passively filtered be @✗ideated .
1- Actively Transported -1-9 Thus short half life .
?⃝
University of Jordan
2021 -
2022 .
, Types of oxidation :
222
phase T Metabolism :
- 1. Ar .
Ring Oxidation
d- v. CYP 45°
Ring g phenol .
# ② oxidation : ( most important) →
(e- Rich)
enzymes Resp for Oxidation
. have Different names :
MOA :
1. Mixed function Oxidases o - Oe
-
A""""
~ Slow And Unlike Glucose kinases the can function @n ←
] unstable OH goes t
many sub . 4- 5 hrs After exposure .
H (e- from
the Ring) Ring
H
R
2. Microsomal isoenzymes .
R€
° " "
?
-
in -
it
,
↳ Referees to 7
liver micro -
molecules .
H.philic ✓
↳
isozymes Differentstructures
~ but same a) Oxigen gives
OR
function → we can put them
. into families : R -
g
its electrons
-
Steroidal Aliphatic , Ar Rings
.
~
They can switch
,
H
.
-
philie
Their jobs ~ Do the function slower .
epoxide
-
might be seen in urine
~
.
3. CYP 450 → protein -1 Co - factor .
: gÑl I'D WIN
This cofactor is A heme group = porforin = 4 fused . Para position
-
SIG is! If I -
"
pyroles 1- ferric Fe
"
in the middle . t.si →, Meta W is is
-
IF its
-
↳ chelation .
-
e- Acceptor -
Coordinate borides .
. Ortho JI I
-
Strong
Note : this heme contains ferric Blood heme contains ferriousfe " This's bc CYP 450 is
strictly Oriented .
→ fe→~ 4 coordinates with N from the heme . .
e- Rich -
Ring JI o's n -8 ni § -
1 ( down) with Midazole from the protein "
~ histidine a. a. ex :
¥ -1
¥ it Ñ
'
1 ( up) with Oz ( source for Oxidation) .
r⇐→⑦ N
-
Deficient .
CL
H
~
why called eyp 450 P .
Clonidine d If É
bc it produces the Red cellular dye upon exposure
To .c=o .
Radical -
gives A Peak At ✗ = 45° '
Moderate speed -
half conj in ← Yeild 50%
Note : glucorinic Acid -
has carboxylic Acid ← vrin ,
half uncharged .
functional group → Anionic Active Transport
~ from plasma to urine ~
After 24 hrs half of the molecules would
in Another word conj . half get passively filtered be @✗ideated .
1- Actively Transported -1-9 Thus short half life .
?⃝
