# Drug interactions -
University of Jordan 2021-2022 .
Examples :
Drug food interactions .
Diltiazem And Verapamil in HFREF .
BB with Asthma .
Example: Non - selective BB with COPD And Asthma .
warfarin and vitamin K containing food. Anti histamines
-
in Constipation .
↳ vitamin K Antagonist PD ,
Affects efficacy .
Diuretics and salty foods
↳ Also Agonist Antagonist
-
Drug Drug interaction
-
.
Griseofulvin and fatty food interaction (increased
absorption) → PK Beneficial Anti fungal]
.
-
#
v1 ✓ b
Milk and tetracycline antibiotics (chelation and Pharmacuties PK PD
inhibition absorption) → PD harmful , .
"
incomparability
"
( Most common) ( limited )
Outside the body
Garlic and antiplatelets or anticoagulants → PD ↳ examples :
→ Additive effect → T Risk of bleeding ( safety) .
1. phenytoin Iv As its pH is
Grape fruit and many drugs (inhibits metabolism
very high 12 .
of amiodarone, cyclosporine) Accumulation of ~
2. Ceftriaxone +
"
Ca contain fluids
g
the drug Toxicity ( safety )
-
.
( Ringer lactate) .
it
may Affect efficacy in some cases .
Note : Remember you can check drug -
PD ~ Two drugs have similar effect .
food interactions At drugs .com .
(
→ Additive -
1+1=2
In most cases,food reduces drug absorption and thus → Synergistic -
1+1>2
inhibits the effects of drug whose actions are related → potentiating - 1+0>1
to Cmax in plasma (hypnotics, CNS stimulants) → Antagonisting -
1-1--0
-
Drug -
Disease interactions .
Occur when a drug unmasks a disease condition or
exacerbates an existing disease → Contraindications .
--
Absolute Relative
Risk Assess met
Common examples of relative contraindications
include pregnancy, breast-feeding, and renal
and hepatic failure. last choice ~
University of Jordan 2021-2022 .
Examples :
Drug food interactions .
Diltiazem And Verapamil in HFREF .
BB with Asthma .
Example: Non - selective BB with COPD And Asthma .
warfarin and vitamin K containing food. Anti histamines
-
in Constipation .
↳ vitamin K Antagonist PD ,
Affects efficacy .
Diuretics and salty foods
↳ Also Agonist Antagonist
-
Drug Drug interaction
-
.
Griseofulvin and fatty food interaction (increased
absorption) → PK Beneficial Anti fungal]
.
-
#
v1 ✓ b
Milk and tetracycline antibiotics (chelation and Pharmacuties PK PD
inhibition absorption) → PD harmful , .
"
incomparability
"
( Most common) ( limited )
Outside the body
Garlic and antiplatelets or anticoagulants → PD ↳ examples :
→ Additive effect → T Risk of bleeding ( safety) .
1. phenytoin Iv As its pH is
Grape fruit and many drugs (inhibits metabolism
very high 12 .
of amiodarone, cyclosporine) Accumulation of ~
2. Ceftriaxone +
"
Ca contain fluids
g
the drug Toxicity ( safety )
-
.
( Ringer lactate) .
it
may Affect efficacy in some cases .
Note : Remember you can check drug -
PD ~ Two drugs have similar effect .
food interactions At drugs .com .
(
→ Additive -
1+1=2
In most cases,food reduces drug absorption and thus → Synergistic -
1+1>2
inhibits the effects of drug whose actions are related → potentiating - 1+0>1
to Cmax in plasma (hypnotics, CNS stimulants) → Antagonisting -
1-1--0
-
Drug -
Disease interactions .
Occur when a drug unmasks a disease condition or
exacerbates an existing disease → Contraindications .
--
Absolute Relative
Risk Assess met
Common examples of relative contraindications
include pregnancy, breast-feeding, and renal
and hepatic failure. last choice ~
