✓
* ② yslipidemia .
✓
The estimated value of LDL cholesterol is found
=
using the Friedewald equation (after fasting for 9–
12 hours):
-
LDL cholesterol (mg/dL) = total cholesterol – (HDL
cholesterol + triglycerides/5),
=
-
=
on-HDL cholesterol can be determined in a
nonfasting state. Non- HDL cholesterol is carried by
all atherogenic Apos B-containing lipoproteins I# It is
including VLDL, IDL, and LDL. It is calculated as: Symptoms
Non-HDL cholesterol = total cholesterol – HDL None to chest pain, palpitations, sweating,
cholesterol As TG can't be measured
~ anxiety, shortness of breath, loss of
we can't find LDL -
consciousness or difficulty with speech or
movement, abdominal pain, sudden death.
in all adults 20 years of age or older at least once Signs
every five years if Abnormal =D more
~ None to abdominal pain, pancreatitis, eruptiv
frequently .
xanthomas, peripheral polyneuropathy, high
blood pressure, body mass index >30 kg/m2
•H↳G or waist size >40 inches in men (35 inches
§BB⑧•s ¥É& in women)
Atherogenic dyslipidemia
Note we don't have
target for
It is characterized by: LDL ~
Optimal 2100 yet
Moderate TG elevation (150 to 500 mg/dL) the lower the better .
Low HDL-C level (<40 mg/dL),
Moderately high LDL-C level Remember : Our threshold is
570 .
1- Metabolic syndrome
Other laboratory tests:
Lipoprotein(a), homocysteine, serum amyloid
A, small dense LDL (pattern B), HDL
subclassification, apolipoprotein E isoforms,
apolipoprotein A-1, fibrinogen, folate,
Chlamydia pneumoniae titer, lipoprotein-
associated phospholipase A2, omega-3 index
Various screening tests for manifestations of
vascular disease (ankle–brachial index, exercis
testing, magnetic resonance imaging) and
diabetes (fasting glucose, oral glucose toleranc
test)
, =D for selected patients we may need * it means if LDL is 200 high intensity statin can towe
calculate 10
to
year Risk
. it to too .
This percentage is kind of based on
theory And
~
Notice that the cutoff differs .
on studies ~ so its not 1001 Accurate . .
Low-risk (<5%) theres No Recommendation toward with
*
starting
Borderline risk (5% to 7.4%) low
intensity statins But we switch to them if the
Intermediate risk (7.5% to 19.9%) patient couldn't cope with the side effects .
High risk (≥20%)
* Non pharmacological -
Same ,
Remember we want to start
with 10% weight Reduction .
As A general Rule we should give statins At bed time But
high intensity statins And pitavastatin can Be given At
of
Anytime the
day .
for
*
elderly we
may prefer to give moderate intensity As
They would suffer from
myopathy .
* Side effects : liver dis function , DM in selected
individuates (Those with Metabolic syndrome) .
if A patient Require moderate
~
intensity statin And you
define fine But we Only Care
give him high intensity
~
tly
About Side effects .
Ezetimibe safety And side
effects profile is similar to placebo
~
Almost nothing .
As injection t.im v6 w
* ② yslipidemia .
✓
The estimated value of LDL cholesterol is found
=
using the Friedewald equation (after fasting for 9–
12 hours):
-
LDL cholesterol (mg/dL) = total cholesterol – (HDL
cholesterol + triglycerides/5),
=
-
=
on-HDL cholesterol can be determined in a
nonfasting state. Non- HDL cholesterol is carried by
all atherogenic Apos B-containing lipoproteins I# It is
including VLDL, IDL, and LDL. It is calculated as: Symptoms
Non-HDL cholesterol = total cholesterol – HDL None to chest pain, palpitations, sweating,
cholesterol As TG can't be measured
~ anxiety, shortness of breath, loss of
we can't find LDL -
consciousness or difficulty with speech or
movement, abdominal pain, sudden death.
in all adults 20 years of age or older at least once Signs
every five years if Abnormal =D more
~ None to abdominal pain, pancreatitis, eruptiv
frequently .
xanthomas, peripheral polyneuropathy, high
blood pressure, body mass index >30 kg/m2
•H↳G or waist size >40 inches in men (35 inches
§BB⑧•s ¥É& in women)
Atherogenic dyslipidemia
Note we don't have
target for
It is characterized by: LDL ~
Optimal 2100 yet
Moderate TG elevation (150 to 500 mg/dL) the lower the better .
Low HDL-C level (<40 mg/dL),
Moderately high LDL-C level Remember : Our threshold is
570 .
1- Metabolic syndrome
Other laboratory tests:
Lipoprotein(a), homocysteine, serum amyloid
A, small dense LDL (pattern B), HDL
subclassification, apolipoprotein E isoforms,
apolipoprotein A-1, fibrinogen, folate,
Chlamydia pneumoniae titer, lipoprotein-
associated phospholipase A2, omega-3 index
Various screening tests for manifestations of
vascular disease (ankle–brachial index, exercis
testing, magnetic resonance imaging) and
diabetes (fasting glucose, oral glucose toleranc
test)
, =D for selected patients we may need * it means if LDL is 200 high intensity statin can towe
calculate 10
to
year Risk
. it to too .
This percentage is kind of based on
theory And
~
Notice that the cutoff differs .
on studies ~ so its not 1001 Accurate . .
Low-risk (<5%) theres No Recommendation toward with
*
starting
Borderline risk (5% to 7.4%) low
intensity statins But we switch to them if the
Intermediate risk (7.5% to 19.9%) patient couldn't cope with the side effects .
High risk (≥20%)
* Non pharmacological -
Same ,
Remember we want to start
with 10% weight Reduction .
As A general Rule we should give statins At bed time But
high intensity statins And pitavastatin can Be given At
of
Anytime the
day .
for
*
elderly we
may prefer to give moderate intensity As
They would suffer from
myopathy .
* Side effects : liver dis function , DM in selected
individuates (Those with Metabolic syndrome) .
if A patient Require moderate
~
intensity statin And you
define fine But we Only Care
give him high intensity
~
tly
About Side effects .
Ezetimibe safety And side
effects profile is similar to placebo
~
Almost nothing .
As injection t.im v6 w
