After diffusing cell membrane, it May control >1000 genes with slow effects
May have NON genomic effect (cytoplasmic) with rapid effects within 30min
Counterin
Increase RBC,PNN,coagulation factors,plasma lipids,intraocular Biologic and blood
profile effects
pressure, catabolism protein ->skin atrophy (no collagen)
Glucocorticoids Hy
Decrease lymphocyte,cytokines,bone matrix,growth retardation
Interaction
Binds to CBG globulin not to albumin and
most of medications bind to albumin so there is no
displacement when we give medications
Classification
Normally hydrocortisone given 20mg/day
But if we give 100mg/day for >2weeks then
we have iatrogenic cushing syndrome In Add
Addison disease 20mg
12H
shock
A-Dexa uses:
1-Organ transplant,cerebral edema Slightly toxic
24H
2-Kc:ctc decrease kc mdt toxicity,Decrease nausea
B-Beta uses :Lung maturation stimulation
12mg 48H before delivery Then after
24H another 12mg then Delivery after 24H 48H
Why beta? : Maternal protein binding is less than other steroids allowing
increased transfer to fetus
May have NON genomic effect (cytoplasmic) with rapid effects within 30min
Counterin
Increase RBC,PNN,coagulation factors,plasma lipids,intraocular Biologic and blood
profile effects
pressure, catabolism protein ->skin atrophy (no collagen)
Glucocorticoids Hy
Decrease lymphocyte,cytokines,bone matrix,growth retardation
Interaction
Binds to CBG globulin not to albumin and
most of medications bind to albumin so there is no
displacement when we give medications
Classification
Normally hydrocortisone given 20mg/day
But if we give 100mg/day for >2weeks then
we have iatrogenic cushing syndrome In Add
Addison disease 20mg
12H
shock
A-Dexa uses:
1-Organ transplant,cerebral edema Slightly toxic
24H
2-Kc:ctc decrease kc mdt toxicity,Decrease nausea
B-Beta uses :Lung maturation stimulation
12mg 48H before delivery Then after
24H another 12mg then Delivery after 24H 48H
Why beta? : Maternal protein binding is less than other steroids allowing
increased transfer to fetus
