1-start LMW heparin at day 0 then day 1 start AVK
When to stop LMW heparin?: if at least 5days of overlap
between AVK and LMW heparin, AND 2 normal INR 24h antivita
apart from each other
Direct X
• characterstics of Rivaroxaban (Trombix) & Apixaban:
1-unique biological target: inhibit specifically
If cancer , renal failure , pregnancy , APLS direct Xa And in a reversible way the facteur Xa
inhibitors are counterindicated
2-oral dose is fixed without tests to control its therapeutic effect
Especially if cancer has a high hemorragic risk like
digestive we prefere LMW heparin which have lower 3-fast action (2h) can be used immediately without previous heparin (unlike AVK)
hemorragic risk than Direct Xa inhibitors
4-Short 1/2 life (12h)
5-partial renal excretion: counterindicated if severe renal failure
When to stop LMW heparin?: if at least 5days of overlap
between AVK and LMW heparin, AND 2 normal INR 24h antivita
apart from each other
Direct X
• characterstics of Rivaroxaban (Trombix) & Apixaban:
1-unique biological target: inhibit specifically
If cancer , renal failure , pregnancy , APLS direct Xa And in a reversible way the facteur Xa
inhibitors are counterindicated
2-oral dose is fixed without tests to control its therapeutic effect
Especially if cancer has a high hemorragic risk like
digestive we prefere LMW heparin which have lower 3-fast action (2h) can be used immediately without previous heparin (unlike AVK)
hemorragic risk than Direct Xa inhibitors
4-Short 1/2 life (12h)
5-partial renal excretion: counterindicated if severe renal failure
