Gastroduodenal Peptic Ulcer
Definition: is a damage of the mucosal barrier, break in-
inner lining of the stomach or duodenum and appears like
.a roughened area
Epidemiology: peptic ulceration is considered nowdays-
.as the most common disease
* 7% of the population will be affected by peptic ulcer in
their lives.
Men are affected 4 times more frequently than women *
.by peptic ulceration
, :Etiology and pathogenesis-
There are many factors that have the importance for
:etiology of gastroduodenal ulcer like
Gastric Hyperacidity .1
Helicobacter Pylori ( H.Pylori Bacteria) -> the .2
H.Pylori bacteria release the enzyme urease which
convers urea into into ammonia, ammonia is toxic for
.the epithelial cells and damage them
Dimineshed definsive factors .3
.mucos layer bicarbonate, phospholipid-
:Induced factors are *
a. Stress
b. Genetic predisposition
.c.Irritiate factors: smoking, caffeine and alcohol
Definition: is a damage of the mucosal barrier, break in-
inner lining of the stomach or duodenum and appears like
.a roughened area
Epidemiology: peptic ulceration is considered nowdays-
.as the most common disease
* 7% of the population will be affected by peptic ulcer in
their lives.
Men are affected 4 times more frequently than women *
.by peptic ulceration
, :Etiology and pathogenesis-
There are many factors that have the importance for
:etiology of gastroduodenal ulcer like
Gastric Hyperacidity .1
Helicobacter Pylori ( H.Pylori Bacteria) -> the .2
H.Pylori bacteria release the enzyme urease which
convers urea into into ammonia, ammonia is toxic for
.the epithelial cells and damage them
Dimineshed definsive factors .3
.mucos layer bicarbonate, phospholipid-
:Induced factors are *
a. Stress
b. Genetic predisposition
.c.Irritiate factors: smoking, caffeine and alcohol
