A MOLECULAR INSIGHT ON THE ANTICANCER EFFECT OF
NATURAL COUMESTAN WEDELOLACTONE IN PA-1 HUMAN
OVARIAN CANCER CELLS
THESIS
Submitted to the partial fulfilment for
the degree of
DOCTOR OF PHILOSOPHY (Ph.D.)
By
R. GLORIA JEMMI CHRISTOBEL, M.Sc., M. Phil.,
DEPARTMENT OF BIOCHEMISTRY
VRR INSTITUTE OF BIOMEDICAL SCIENCE
(AFFILIATED TO UNIVERSITY OF MADRAS)
CHENNAI – 600 056.
OCTOBER - 2020
, VRR INSTITUTE OF BIOMEDICAL SCIENCE
(Affiliated to University of Madras)
1/7, MRB Avenue, Kattupakkam, Chennai-600056.
Ph: +91 44 26791700, Fax: +91 44 2436 0219, Email:
Dr. P.Rasappan
Director- Research
Department of Biochemistry
CERTIFICATE FROM THE SUPERVISOR
I certify that the thesis entitled “A molecular insight on the anticancer effect of
natural coumestan Wedelolactone in PA-1 human ovarian cancer cells”
submitted for the degree of Doctor of Philosophy (Ph.D.) by R. Gloria Jemmi
Christobel is the record of research work carried out by him during the period of
study in the Department of Biochemistry, VRR Institute of Biomedical Science
(Affiliated to University of Madras), Chennai - 600 056, under my guidance and
supervision. This thesis work has not formed the basis for the award of any degree,
diploma, associateship, fellowship or other similar titles.
Place: Chennai - 600 056 (Dr.P.Rasappan)
Date:
, VRR INSTITUTE OF BIOMEDICAL SCIENCE
(Affiliated to University of Madras)
1/7, MRB Avenue, Kattupakkam, Chennai-600056.
Ph: +91 44 26791700, Fax: +91 44 2436 0219, Email:
Dr. P.Rasappan
Director- Research
Department of Biochemistry
STATEMENT FROM THE SUPERVISOR
This is to certify that the thesis entitled “A molecular insight on the
anticancer effect of natural coumestan Wedelolactone in PA-1 human
ovarian cancer cells” submitted by R. Gloria Jemmi Christobel in partial
fulfillment for the Degree of Doctor of Philosophy, to University of Madras,
represents in full the independent work done by him under my guidance.
Place: Chennai - 600 056 (Dr. P.Rasappan)
Date:
, DECLARATION BY THE CANDIDATE
I, R .Gloria Jemmi Christobel hereby declare that the thesis entitled
“A molecular insight on the anticancer effect of natural coumestan
Wedelolactone in PA-1 human ovarian cancer cells” submitted by me for the
degree of Doctor of Philosophy (Ph.D) is the record of work carried out by me during
the period of my study under the guidance of Dr. P. Rasappan, Department of
Biochemistry, VRR Institute of Biomedical Science (Affiliated to University of
Madras), Chennai - 600 056 and that it has not formed the basis for the award of any
degree, diploma, associateship, fellowship or other similar titles.
Place: Chennai - 600 056 (R. Gloria Jemmi Christobel)
Date:
NATURAL COUMESTAN WEDELOLACTONE IN PA-1 HUMAN
OVARIAN CANCER CELLS
THESIS
Submitted to the partial fulfilment for
the degree of
DOCTOR OF PHILOSOPHY (Ph.D.)
By
R. GLORIA JEMMI CHRISTOBEL, M.Sc., M. Phil.,
DEPARTMENT OF BIOCHEMISTRY
VRR INSTITUTE OF BIOMEDICAL SCIENCE
(AFFILIATED TO UNIVERSITY OF MADRAS)
CHENNAI – 600 056.
OCTOBER - 2020
, VRR INSTITUTE OF BIOMEDICAL SCIENCE
(Affiliated to University of Madras)
1/7, MRB Avenue, Kattupakkam, Chennai-600056.
Ph: +91 44 26791700, Fax: +91 44 2436 0219, Email:
Dr. P.Rasappan
Director- Research
Department of Biochemistry
CERTIFICATE FROM THE SUPERVISOR
I certify that the thesis entitled “A molecular insight on the anticancer effect of
natural coumestan Wedelolactone in PA-1 human ovarian cancer cells”
submitted for the degree of Doctor of Philosophy (Ph.D.) by R. Gloria Jemmi
Christobel is the record of research work carried out by him during the period of
study in the Department of Biochemistry, VRR Institute of Biomedical Science
(Affiliated to University of Madras), Chennai - 600 056, under my guidance and
supervision. This thesis work has not formed the basis for the award of any degree,
diploma, associateship, fellowship or other similar titles.
Place: Chennai - 600 056 (Dr.P.Rasappan)
Date:
, VRR INSTITUTE OF BIOMEDICAL SCIENCE
(Affiliated to University of Madras)
1/7, MRB Avenue, Kattupakkam, Chennai-600056.
Ph: +91 44 26791700, Fax: +91 44 2436 0219, Email:
Dr. P.Rasappan
Director- Research
Department of Biochemistry
STATEMENT FROM THE SUPERVISOR
This is to certify that the thesis entitled “A molecular insight on the
anticancer effect of natural coumestan Wedelolactone in PA-1 human
ovarian cancer cells” submitted by R. Gloria Jemmi Christobel in partial
fulfillment for the Degree of Doctor of Philosophy, to University of Madras,
represents in full the independent work done by him under my guidance.
Place: Chennai - 600 056 (Dr. P.Rasappan)
Date:
, DECLARATION BY THE CANDIDATE
I, R .Gloria Jemmi Christobel hereby declare that the thesis entitled
“A molecular insight on the anticancer effect of natural coumestan
Wedelolactone in PA-1 human ovarian cancer cells” submitted by me for the
degree of Doctor of Philosophy (Ph.D) is the record of work carried out by me during
the period of my study under the guidance of Dr. P. Rasappan, Department of
Biochemistry, VRR Institute of Biomedical Science (Affiliated to University of
Madras), Chennai - 600 056 and that it has not formed the basis for the award of any
degree, diploma, associateship, fellowship or other similar titles.
Place: Chennai - 600 056 (R. Gloria Jemmi Christobel)
Date:
