First Aid USMLE STEP 1 flashcards
follicle Ans- site in lymph node of B cell localization and proliferation
paracortex Ans- site in lymph node that houses T cells
third Ans- What pharyngeal pouch is the thymus derived from?
MHC I Ans- present endogenously synthesized antigens?
MHC II Ans- present exogenously synthesized antigens?
MHC I Ans- antigen peptides are loaded onto MHC I in RER after delivery via TAP?
MHC II Ans- antigen loaded following release of invariant chain in an acidifed
endosome?
CD8 T cell Ans- Tcell that directly kills virus infected cells?
cortex Ans- What part of the thymus does positive selection of T cells occur in?
medulla Ans- What part of the thymus does negative selection of T cells occur in?
autoimmune polyendocrine syndrome-1 Ans- Deficiency of autoimmune regulator AIRE
in negative selection leads to what syndrome?
Th1 cell Ans- Helper T cell type that secrets IFN-y?
Th2 cell Ans- Helper T cell type that secretes IL4, IL5, IL10, and IL13?
IL 10 and TGF B Ans- The anti inflammatory cytokines?
IgG Ans- Immunoglobulin that can cross the placenta?
C3b Ans- Complement protein for opsonization?
C3a, C4a, C5a Ans- Complement proteins for anaphylaxis?
C5a Ans- complement protein for neutrophil chemotaxis?
C3b Ans- complement protein that helps clear immune complexes?
, C1 esterase inhibitor deficiency Ans- Complement disorder that causes hereditary
angioedema due to unregulated activation of kallidrein which leads to inc bradykinin and
Ace inhibitors are contraindicated?
C3 deficiency Ans- complement disorder that inc risk of severe, recurrent pyogenic
sinus and respiratory tract infections and inc susceptibility to type III hypersensitivity
reactions?
C5-C9 deficiency Ans- complement disorder that inc susceptibility to recurrent Neisseria
bacteremia?
DAF (GPI-anchored enzyme) deficiency Ans- Causes complement-mediated lysis of
RBCs and paroxysmal nocturnal hemoglobinuria?
IL-12 Ans- Cytokine that induces differentiation of T cells into TH1 cells and activates
NK cells?
Chronic granulomatous disease Ans- Disease with NADPH oxidase deficiency and
patients are at higher risk for infection by catalase positive species?
BCG, intranasal influenza, MMR, sabin polio, varicella, yellow fever Ans- The live
attenuated vaccines?
Rabes, influenza (injection), Polio (salk), hep A (RIP Always) Ans- The inactivated or
killed vaccines?
histamine and tryptase Ans- In anaphylaxis, what do mast cells release?
Type I Ans- The hypersensitivity reaction that is anaphylactic and atopic?
Type II Ans- The hypersensitivity reaction that is cytotoxic (antibody mediated)?
Type III Ans- The hypersensitivity reaction that is immune complex-antigen antibody
mediated?
Type IV Ans- The hypersensitivity reaction that is delayed (T cell mediated?
Myasthenia gravis Ans- Anti-ACh receptor autoantibody is assoc with which disorder?
Goodpasture syndrome Ans- Anti-basement membrane autoantibody is assoc with
which disorder?
SLE, antiphospholipid syndrome Ans- Anticardiolipin and lupus anticoagulant are assoc
with which disorders?
follicle Ans- site in lymph node of B cell localization and proliferation
paracortex Ans- site in lymph node that houses T cells
third Ans- What pharyngeal pouch is the thymus derived from?
MHC I Ans- present endogenously synthesized antigens?
MHC II Ans- present exogenously synthesized antigens?
MHC I Ans- antigen peptides are loaded onto MHC I in RER after delivery via TAP?
MHC II Ans- antigen loaded following release of invariant chain in an acidifed
endosome?
CD8 T cell Ans- Tcell that directly kills virus infected cells?
cortex Ans- What part of the thymus does positive selection of T cells occur in?
medulla Ans- What part of the thymus does negative selection of T cells occur in?
autoimmune polyendocrine syndrome-1 Ans- Deficiency of autoimmune regulator AIRE
in negative selection leads to what syndrome?
Th1 cell Ans- Helper T cell type that secrets IFN-y?
Th2 cell Ans- Helper T cell type that secretes IL4, IL5, IL10, and IL13?
IL 10 and TGF B Ans- The anti inflammatory cytokines?
IgG Ans- Immunoglobulin that can cross the placenta?
C3b Ans- Complement protein for opsonization?
C3a, C4a, C5a Ans- Complement proteins for anaphylaxis?
C5a Ans- complement protein for neutrophil chemotaxis?
C3b Ans- complement protein that helps clear immune complexes?
, C1 esterase inhibitor deficiency Ans- Complement disorder that causes hereditary
angioedema due to unregulated activation of kallidrein which leads to inc bradykinin and
Ace inhibitors are contraindicated?
C3 deficiency Ans- complement disorder that inc risk of severe, recurrent pyogenic
sinus and respiratory tract infections and inc susceptibility to type III hypersensitivity
reactions?
C5-C9 deficiency Ans- complement disorder that inc susceptibility to recurrent Neisseria
bacteremia?
DAF (GPI-anchored enzyme) deficiency Ans- Causes complement-mediated lysis of
RBCs and paroxysmal nocturnal hemoglobinuria?
IL-12 Ans- Cytokine that induces differentiation of T cells into TH1 cells and activates
NK cells?
Chronic granulomatous disease Ans- Disease with NADPH oxidase deficiency and
patients are at higher risk for infection by catalase positive species?
BCG, intranasal influenza, MMR, sabin polio, varicella, yellow fever Ans- The live
attenuated vaccines?
Rabes, influenza (injection), Polio (salk), hep A (RIP Always) Ans- The inactivated or
killed vaccines?
histamine and tryptase Ans- In anaphylaxis, what do mast cells release?
Type I Ans- The hypersensitivity reaction that is anaphylactic and atopic?
Type II Ans- The hypersensitivity reaction that is cytotoxic (antibody mediated)?
Type III Ans- The hypersensitivity reaction that is immune complex-antigen antibody
mediated?
Type IV Ans- The hypersensitivity reaction that is delayed (T cell mediated?
Myasthenia gravis Ans- Anti-ACh receptor autoantibody is assoc with which disorder?
Goodpasture syndrome Ans- Anti-basement membrane autoantibody is assoc with
which disorder?
SLE, antiphospholipid syndrome Ans- Anticardiolipin and lupus anticoagulant are assoc
with which disorders?
