Chapter 19: Alterations of Hormonal Regulation Huether & McCance: Understanding Pathophysiology, 6th Edition

1. Besides hyposecretion and hypersecretion, endocrine system dysfunction can result from: a. abnormal receptor activity. b. abnormal hormone levels. c. increased synthesis of second messengers. d. extracellular electrolyte alterations. ANS: A Dysfunction may result from abnormal cell receptor function or from altered intracellular response to the hormone-receptor complex. Abnormal hormone levels can occur but are not the cause of endocrine dysfunction. Intracellular storage of second-messenger hormones would not lead to dysfunction; receptor function does. Extracellular electrolyte alterations may result from dysfunction, but they are not a cause. REF: p. 460 2. What is the most common cause of elevated levels of antidiuretic hormone (ADH) secretion? a. Autoimmune disease b. Cancer c. Pregnancy d. Heart failure ANS: B The most common cause of elevated levels of ADH is cancer, not autoimmune disorders, pregnancy, or heart failure. REF: p. 461