1-Absorption : see molecular weight
If >500 oral absorption is poor
If <500 oral absorption is possible
See -OH groups
Pharmacokinetics
2-Distribution :
BBB
General mechanism of action
Placenta/lactation
Body fluids
3-Metabolism: liver
4-Excretion:liver kidney
, Hypersensitivity reaction (HAR) : 5-10% in population 1/10,000 will procainpenicllin intrathecal high dose : Seizures
have anaphylactic shock
Nefcillin : Bone marrow depression
Sometimes immediate (HSR1) or after 12j (HSR III immune complex)
Methicillin no more used ,interstitial nephritis
Metabolic products are responsible for this HSR not penicillin itself
Clavulinic acid: hepatotoxic
HSR dvp over time, we are not born with
Skin HSR test
Side effects
IV:Benzyl
IM:benzacin Drug in
PO:peni-A
route
empty stomach B-lactamase p
1h before or after meal Kinetic Penicillin = peni
Not ionized but become ionized (+) in blood BBB
Can’t pass BBB except if meningitis
Can pass placenta but not teratogenic
Excretion
renal Excretion by tubular secretion
Types
Probenicide 500mg 1cp:
prolong duration of action of penicillin
By diminishing its excretion
Nafcillin biliary excretion
Extended spectr
Antistaph=betalactamase resistant peni
Benzylpenicillin (peni-G) G+ and G-
-cillin
The only one measured with IU not with gram
Because comes from natural source
If >500 oral absorption is poor
If <500 oral absorption is possible
See -OH groups
Pharmacokinetics
2-Distribution :
BBB
General mechanism of action
Placenta/lactation
Body fluids
3-Metabolism: liver
4-Excretion:liver kidney
, Hypersensitivity reaction (HAR) : 5-10% in population 1/10,000 will procainpenicllin intrathecal high dose : Seizures
have anaphylactic shock
Nefcillin : Bone marrow depression
Sometimes immediate (HSR1) or after 12j (HSR III immune complex)
Methicillin no more used ,interstitial nephritis
Metabolic products are responsible for this HSR not penicillin itself
Clavulinic acid: hepatotoxic
HSR dvp over time, we are not born with
Skin HSR test
Side effects
IV:Benzyl
IM:benzacin Drug in
PO:peni-A
route
empty stomach B-lactamase p
1h before or after meal Kinetic Penicillin = peni
Not ionized but become ionized (+) in blood BBB
Can’t pass BBB except if meningitis
Can pass placenta but not teratogenic
Excretion
renal Excretion by tubular secretion
Types
Probenicide 500mg 1cp:
prolong duration of action of penicillin
By diminishing its excretion
Nafcillin biliary excretion
Extended spectr
Antistaph=betalactamase resistant peni
Benzylpenicillin (peni-G) G+ and G-
-cillin
The only one measured with IU not with gram
Because comes from natural source
