Summary NR 565 Advanced Pharmacology Fundamentals Week 3 Chapter 1

Alpha1 iReceptors: iMostly iassociated iwith iexcitation ior istimulation iand iare ifound imainly iin ithe ieye, isalivary iglands, iarterioles, ipostcapillary ivenules, iand iGI iand iGU isphincters. Alpha2 iReceptors: iMostly iassociated iwith irelaxation ior iwith iinhibition iof inorephinephrine irelease, iand ithe imajority iare ilocated iin ithe ipresynaptic inerve iterminals iof ismooth imuscles, ithe iislet icells iof ithe ipancreas, isalivary iglands, iskin, iand imucosa. Beta1 iReceptors: iFound imostly iin ithe iheart, ibrain, ikidney, iand ilipocytes iare iassociated iwith istimulation iof iadenylyl icyclase ivia iG5-G-protein-coupled ireceptors ito iincrease icAMP iproduction. Beta2 iReceptors: iLocated iin ithe ismooth imuscle iof ithe ieye, iarterioles, ivenules, ibronchioles, iliver, ipancreas, iand iGI iand iGU isystems. iThey istimulate iadenylyl icyclase, iincrease icAMP, iand iactivate icardiac iG1 iunder icertain iconditions. Norepinephrine: iStimulates ithe ialpha iand ibeta1 ireceptors. Epinephrine: iStimulates iall ifour itypes iof ireceptors.