C785 FINAL EXAM 1 2022 DETAILED AND
COMPLETE SOLUTIONS
Which mRNA sequence results in a polypeptide that contains three amino acids?
(correct answers)5' - CUU GAU ACU UAG - 3'
Which RNA sequence would end in the following polypeptide?
Phe-Thr-Val-Stop
(correct answers)5' - UUC ACA GUA UAA - 3'
What is the complementary sequence for the following DNA sequence?
5' - GCC ATC TCG AAT - 3'
(correct answers)5' - ATT CGA GAT GGC - 3'
Assuming 100% reaction efficiency, how many DNA copies are created after the completion of four
complete PCR cycles?
(correct answers)16
What is the function of DNA polymerase in the process of PCR?
(correct answers)It recognizes the primers and uses the available dNTPs to replicate the template DNA
sequence.
5' - [...] ATT CGC TAG GGC [...] - 3' − Normal DNA
5' - [...] ATT CGC GAG GGC [...] - 3' − Mutant DNA
, Which type of mutation and outcome characterizes the Mutant DNA?
(correct answers)A missense mutation leading to a longer protein
In sickle-cell disease, the glutamic acid (Glu) at position number seven is mutated to valine (Val).
What change in codons corresponds to this mutation?
(correct answers)GAA to GTA
What are possible blood types of the parents of a patient with blood type AB?
(correct answers)A and B
Which pair of chromosomes accurately depicts the genotype of a person with an autosomal recessive
mutant HBB allele and sickle cell anemia?
(correct answers)option 3- 2 mutant genes on chromosome 11
Which pair of chromosomes accurately depicts the genotype of a person with an X-linked recessive
mutant ALAS2 allele and sideroblastic anemia?
(correct answers)option 3, mutated allele
Studies have shown that increased expression of two genes called SIRT1 and SIRT2 is associated with
chronic exposure to cocaine and contributes to drug addiction.
What difference in the regions of the SIRT1 and SIRT2 genes in people addicted to cocaine increases
their expression?
(correct answers)The nucleosomes become more widely spaced.
COMPLETE SOLUTIONS
Which mRNA sequence results in a polypeptide that contains three amino acids?
(correct answers)5' - CUU GAU ACU UAG - 3'
Which RNA sequence would end in the following polypeptide?
Phe-Thr-Val-Stop
(correct answers)5' - UUC ACA GUA UAA - 3'
What is the complementary sequence for the following DNA sequence?
5' - GCC ATC TCG AAT - 3'
(correct answers)5' - ATT CGA GAT GGC - 3'
Assuming 100% reaction efficiency, how many DNA copies are created after the completion of four
complete PCR cycles?
(correct answers)16
What is the function of DNA polymerase in the process of PCR?
(correct answers)It recognizes the primers and uses the available dNTPs to replicate the template DNA
sequence.
5' - [...] ATT CGC TAG GGC [...] - 3' − Normal DNA
5' - [...] ATT CGC GAG GGC [...] - 3' − Mutant DNA
, Which type of mutation and outcome characterizes the Mutant DNA?
(correct answers)A missense mutation leading to a longer protein
In sickle-cell disease, the glutamic acid (Glu) at position number seven is mutated to valine (Val).
What change in codons corresponds to this mutation?
(correct answers)GAA to GTA
What are possible blood types of the parents of a patient with blood type AB?
(correct answers)A and B
Which pair of chromosomes accurately depicts the genotype of a person with an autosomal recessive
mutant HBB allele and sickle cell anemia?
(correct answers)option 3- 2 mutant genes on chromosome 11
Which pair of chromosomes accurately depicts the genotype of a person with an X-linked recessive
mutant ALAS2 allele and sideroblastic anemia?
(correct answers)option 3, mutated allele
Studies have shown that increased expression of two genes called SIRT1 and SIRT2 is associated with
chronic exposure to cocaine and contributes to drug addiction.
What difference in the regions of the SIRT1 and SIRT2 genes in people addicted to cocaine increases
their expression?
(correct answers)The nucleosomes become more widely spaced.
