Summary NR 565 WEEK 6 CHAPTER 24 Drugs used in treating infectious diseases

ANTIMYCOBACTERIALS Mycobacteria- iamong ithe imost idifficult ito icure i(e.g. ituberculosis i[TB]) o They igrow islowly iand iare irelatively iresistant ito idrugs ithat iare ilargely idependent ion ihow irapidly icells iare idividing o Have ia ilipid-rich icell iwall irelatively iimpermeable ito imany idrugs o Are iusually iintracellular iand iinaccessible ito idrugs ithat idoes inot ihave igood iintracellular ipenetration o Have ithe iability ito igo iinto ia idormant istate o Easily idevelop iresistance ito iany isingle idrugs o Pregnancy icategories: ▪ Isoniazid: iPregnancy icategory iA ▪ Streptomycin: iPregnancy icategory iD ▪ The irest: iPregnancy icategory iC ▪ Fetal ideath- id/t iTB: iisoniazid i+ irifampin i+ iethambutol ifor iTB itx iif ipregnant iand iif idrug iresistance iis ia possibility. • Spectrum iof icoverage ifor ivarious iorganisms/Pharmacodynamics o Isoniazid i- imost iactive idrug ifor itx iof iTB ▪ Bactericidal- iagainst isusceptible imycobacteria i(intracellular iand iextracellular iorganisms) ▪ Interferes iwith ilipid iand inucleic iacid ibiosynthesis iin igrowing iorganisms. ▪ Isoniazid iand iethambutol- iinhibits isynthesis iof imycolic iacid i(important iconstituents ifor imycobacteria icell iwalls and iare inot ifound iin imammalian icells).