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NR508 Week 7 Grand Rounds replies/post

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NR508 Week 7 Grand Rounds replies/post “In participation responses to presentations, discusses a drug that could be prescribed for the condition DIFFERENT than those presented. Presents an alternate treatment plan from the Walmart or Target $4 RX list, and offers reasons for the change or if the drug is not on the list, why? Uses scholarly, evidenced based references to support responses.” Great Presentation, lots of good information was covered! Great follow up slide as well! The list narrows when discussing medications for Hypothyroidism. The only $4 thyroid replacement therapy is Levothyroxine which you discussed in your presentation. I will point out that the $4 prescription is a 30-day supply while there is also a $10 90 supply available as well if the practitioner writes the order as such which will save the patient $2 overall in filling a 90-day supply. I will give a clinical scenario where a patient was previously prescribed Levothyroxine but now her practitioner is switching her to a non-synthetic form, Armour Thyroid, due to some adverse reactions to the synthetic form. This is a Desiccated thyroid extract that is made from animal (pigs) thyroid glands. In an article written by McAninch & Bianco (2016) they noted a study showing a patient preference to desiccated thyroid extract over L-Thyroxine monotherapy and patients happened to experience weight loss in conjunction with therapy. Usual starting dose of Armour Thyroid is 30mg with incremental dosing of 15mg every 2-4 weeks depending on lab values. If patient has a history of cardiac disorders or angina, then an initial starting dose of 15mg is recommended. Maintenance dosing is between 60-120mg/day. Drug interactions may occur with anticoagulants as thyroid hormone appears to intensification catabolism of vitamin K. Questions: Electronic Medical Records are improving the safety of prescribing medications? True Which Hormone is considered the most natural for supplementation? T4 Supplementation The preferred hormone replacement treatment during pregnancy is Levothyroxine? True, safe during pregnancy and for babies. What is the most common cause of hypothyroidism in the United States? Autoimmune disease Patients with a TSH greater than 10 micro units/ml should be treated? True McAninch, E. A., & Bianco, A. C. (2016). The History and Future of Treatment of Hypothyroidism. Annals Of Internal Medicine, 164(1), 50-56. doi:10.7326/M15-1799 Great topic and presentation as it effects many women in todays society. I myself know of a handful of friends that are dealing with PCOS and it has become a daily stressor on their lives. I did have a difficult time hearing all of what you had to say due to the mic going in and out, so I did look up some of the answers as to you may have discussed them when I was unable to pick up what you were saying on the microphone. As you mentioned all of the medications on the $4 prescribing list I will discuss another, there was an oral contraceptive on $9 list but alas not on the $4 list. As you mentioned Metformin is a first line therapeutic treatment, Actos has also been found to be effective; “Rosiglitazone and pioglitazone are also effective for ameliorating hirsutism and insulin resistance” (Radosh, 2009). Though not a popular choice over the Metformin which has proven efficancy, Actos (Pioglitazone) is a thiazolidinediones and is an effective insulin sensitizing agent. Also effective in the treatment of hirsutism, infertility and of course insulin resistance. The typical dosage for Actos is 30mg daily. One reason this medication is not commonly used for PCOS treatment is one of the side effects is CHF and or CHF exacerbation, so signs and symptoms of heart failure need to be monitored closely. Patients are also more prone to weight gain with Actos then with Metformin. From the information I just posted about Actos I would not consider it over Metformin unless absolutely needed and with careful observation. 1. Which of the following may be part of the treatment plan for pcos? all of the above: transvaginal ultrasound, Serum testosterone levels, Fasting glucose and 2 hour glucose tolerance test: 2. Which of the following complication is associated with PCOS? Type 2 diabetes mellitus (women with PCOS were more likely to have a diagnosis of diabetes (Sirmans, Parish, Blake, & Wang, 2014). 3. PCOS complications include endometrial hyperplasia and increased risk for obstetrical complications? TRUE 4. oral contraceptives and metformin and the diuretic ?, is used for its anti-androgenic properties as treatment for PCOS? Spironolactone 5. Metformin is used in the treatment of PCOS to treat insulin resistance? True Radosh, L. (2009, April 15). Drug Treatments for Polycystic Ovary Syndrome. Retrieved August 20, 2018, from Sirmans, S. M., Parish, R. C., Blake, S., & Wang, X. (2014). Epidemiology and Comorbidities of Polycystic Ovary Syndrome in an Indigent Population. Journal of Investigative Medicine, 62(6), 868-874. doi:10.1097/.4.90599.5d Great presentation on Anxiety! I know this is something that we will be seeing in clinic on a daily basis so having a strong understanding of the medications associated with it are very important to our future practice. I would like to start this patient on Buspirone as initial treatment, a breakthrough benzodiazepine can be paired with it for 4 weeks giving the Buspirone time to take effect. According to Rabatin and Keltz (2002) Initial therapy may consist of the administration of a benzodiazepine for 2to 6 weeks or buspirone hydrochloride for several months“Buspar/Buspirone is a good treatment option for a patient diagnosed with GAD and can also be used in short term treatment as well. This medication is also less likely to cause cognitive impairment which will be beneficial for our patient that is a working mother that probably cannot lack to have any cognitive impairment. AHFS Drug Information Essentials 2018 text noted that the efficacy of Buspirone generally compares to that of benzodiazepines in management of GAD. (This medication is also on the $4 prescription list, so it is affordable to our patients. The recommended initial dosage is 7.5mg BID. Maximum dosage is 60mg daily. 1) Serotonin-Selective Reuptake Inhibitors (SSRIs) Work by: C) Increasing the serotonin availability in the synaptic area 2) All of the following are signs of serotonin syndrome except: D) Hypothermia 3) An alternative to SSRI that does not have the side of effect of decrease libido is: Buspirone 4) Benzodiazepines act by stimulating GABAₐ leading to less excitability from the post synaptic neuron. A) True 5) A supplement that should not be taken with SSRI due to the possibility of increase risk of serotonin syndrome is: B) St. John’s wort busPIRone Hydrochloride. (2018). AHFS Drug Information Essentials Bethesda, Maryland: American Society of Health-System Pharmacists, Inc. Retrieved from Rabatin, J., & Keltz, L. B. (2002, May). Generalized anxiety and panic disorder. Retrieved August 20, 2018, from Even during my research on Parkinson’s Disease, I never ran across this mediation so I am glad you asked me about it! Pimavanserin is the first FDA-approved drug indicated for the treatment of hallucinations and delusions in Parkinson’s Disease associated psychosis. This medication was approved by the FDA fairly recently, 2016. Per Cruz (2017), it a first in class atypical antipsychotic that does not induce clinically significant antagonism of dopaminergic, adrenergic, histaminergic, or muscarinic receptors. The exact mechanism of action is unknown but it theory works by an inverse combination of agonist and antagonist activity. The cost of Pimavanserin is substantial, the average cash price is $2,560 for a 1-month supply of 17mg tablets to be taken PO BID. I was able to find a program called Prescription Hope that can help those acquire this medication for only $50/month for earning under $100,000/annually. There was a black box warning noted that this medication increased mortality in the elderly (those greater than 65 y/o). There is also a contraindication to avoid drugs that prolong a patient’s QT interval, as Pimavanserin can potentially increase/prolong QT as well. Cruz, M. P. (2017, June). Pimavanserin (Nuplazid) A Treatment for Hallucinations and Delusions Associated With Parkinson’s Disease. Retrieved August 22, 2018, from

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NR508 Week 7 Grand Rounds replies/post
“In participation responses to presentations, discusses a drug that could be prescribed
for the condition DIFFERENT than those presented. Presents an alternate treatment plan
from the Walmart or Target $4 RX list, and offers reasons for the change or if the drug is
not on the list, why? Uses scholarly, evidenced based references to support responses.”

Great Presentation, lots of good information was covered! Great follow up slide as well! The list narrows
when discussing medications for Hypothyroidism. The only $4 thyroid replacement therapy is
Levothyroxine which you discussed in your presentation. I will point out that the $4 prescription is a 30-
day supply while there is also a $10 90 supply available as well if the practitioner writes the order as
such which will save the patient $2 overall in filling a 90-day supply.

I will give a clinical scenario where a patient was previously prescribed Levothyroxine but now her
practitioner is switching her to a non-synthetic form, Armour Thyroid, due to some adverse reactions to
the synthetic form. This is a Desiccated thyroid extract that is made from animal (pigs) thyroid glands. In
an article written by McAninch & Bianco (2016) they noted a study showing a patient preference to
desiccated thyroid extract over L-Thyroxine monotherapy and patients happened to experience weight
loss in conjunction with therapy. Usual starting dose of Armour Thyroid is 30mg with incremental dosing
of 15mg every 2-4 weeks depending on lab values. If patient has a history of cardiac disorders or angina,
then an initial starting dose of 15mg is recommended. Maintenance dosing is between 60-120mg/day.
Drug interactions may occur with anticoagulants as thyroid hormone appears to intensification
catabolism of vitamin K.

Questions:

Electronic Medical Records are improving the safety of prescribing medications? True

Which Hormone is considered the most natural for supplementation? T4 Supplementation

The preferred hormone replacement treatment during pregnancy is Levothyroxine? True, safe during
pregnancy and for babies.

What is the most common cause of hypothyroidism in the United States? Autoimmune disease

Patients with a TSH greater than 10 micro units/ml should be treated? True


McAninch, E. A., & Bianco, A. C. (2016). The History and Future of Treatment of Hypothyroidism. Annals
Of Internal Medicine, 164(1), 50-56. doi:10.7326/M15-1799



Great topic and presentation as it effects many women in todays society. I myself know of a handful of
friends that are dealing with PCOS and it has become a daily stressor on their lives. I did have a difficult
time hearing all of what you had to say due to the mic going in and out, so I did look up some of the
answers as to you may have discussed them when I was unable to pick up what you were saying on the
microphone. As you mentioned all of the medications on the $4 prescribing list I will discuss another,
there was an oral contraceptive on $9 list but alas not on the $4 list.

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