BIOLOGY 130 CHAPTER
16 STUDY QUESTIONS
Question 1 of 10
0.33/ 1.0 Points
If every cell in the body gets the same DNA, how do the cells of an embryo make different
structures and take on different roles? (Select all that apply.)
A. Different transcription factors are active in different
cells. B. Different transcription factors are encoded in the
DNA. C. Genes are spliced differently in different cells.
D. Translation is regulated so that different cells may make more of certain proteins.
E. Some cells lack ribosomes while others use them.
F. Cells delete a set of unused genes from their chromosomes.
Feedback: Learning Objective Text: Analyze the processes of gene expression and gene
regulation
Question 2 of 10
1.0/ 1.0 Points
A gene is made up of three exons (numbered consecutively) with two introns (intron 1 between
exons 1 and 2 and intron 2 between exons 2 and 3). What would happen if there were a mutation
at the 3’ splice site of intron 1?
A. mRNA with all three exons and both introns
B. mRNA with all three exons along with intron
1
C. mRNA with only exons 2 and 3
D. mRNA with exons 2 and 3 along with intron 2
Feedback: Correct
Question 3 of 10
1.0/ 1.0 Points
What would happen if there were a mutation in the operator of the trp operon?
A. the trp operon would not be able to express the genes
B. the CAP protein couldn't bind, therefore shutting off the
genes C. the trp operon would continuously express the genes
D. RNA polymerase could not recognize the promoter, so transcription would not occur
Feedback: Correct
Question 4 of 10
1.0/ 1.0 Points
Overexpression of miRNAs can lead to a decrease of protein expression associated with some
forms of cancer. What could a drug do to counter this effect?
A. increase promoter activity of the miRNA genes
B. decrease expression of RNA polymerase
C. increase expression of RISC
, D. decrease expression of miRNA
Feedback: Learning Objective: Discuss how understanding regulation of gene expression can
lead to better drug design
Question 5 of 10
1.0/ 1.0 Points
What part of the ribosome is important in catalyzing peptide bonds?
A. the methyl guanosine cap
B. the rRNA
C. the ribosomal proteins
D. the E site
Feedback: Correct
Question 6 of 10
1.0/ 1.0 Points
is the first protein to bind to mRNA to being initiation of translation.
A. TFIIA
B. eIF-2
C. TFIID
D. 60S ribosomal subunit
E. 40S ribosomal subunit
Question 7 of 10
1.0/ 1.0 Points
Epigenetics refers to a special kind of hereditary mechanism. Epigenetic changes do not change
the DNA nucleotide sequence, yet their effect on gene expression can last for several
generations.
In one surprising study, it was found that the grandsons of men who suffered a famine were less
likely to die of cardiovascular disease. The experience of famine made some cardio-protective
change in the sperm of those grandfathers that was passed on.
What type of change was likely responsible?
A. histone acetylation or DNA methylation
B. transcription factor activity
C. ubiquitin tagging
D. phosphatase levels
Feedback: Learning Objective: Analyze the processes of gene expression and gene regulation
Question 8 of 10
0.0/ 1.0 Points
16 STUDY QUESTIONS
Question 1 of 10
0.33/ 1.0 Points
If every cell in the body gets the same DNA, how do the cells of an embryo make different
structures and take on different roles? (Select all that apply.)
A. Different transcription factors are active in different
cells. B. Different transcription factors are encoded in the
DNA. C. Genes are spliced differently in different cells.
D. Translation is regulated so that different cells may make more of certain proteins.
E. Some cells lack ribosomes while others use them.
F. Cells delete a set of unused genes from their chromosomes.
Feedback: Learning Objective Text: Analyze the processes of gene expression and gene
regulation
Question 2 of 10
1.0/ 1.0 Points
A gene is made up of three exons (numbered consecutively) with two introns (intron 1 between
exons 1 and 2 and intron 2 between exons 2 and 3). What would happen if there were a mutation
at the 3’ splice site of intron 1?
A. mRNA with all three exons and both introns
B. mRNA with all three exons along with intron
1
C. mRNA with only exons 2 and 3
D. mRNA with exons 2 and 3 along with intron 2
Feedback: Correct
Question 3 of 10
1.0/ 1.0 Points
What would happen if there were a mutation in the operator of the trp operon?
A. the trp operon would not be able to express the genes
B. the CAP protein couldn't bind, therefore shutting off the
genes C. the trp operon would continuously express the genes
D. RNA polymerase could not recognize the promoter, so transcription would not occur
Feedback: Correct
Question 4 of 10
1.0/ 1.0 Points
Overexpression of miRNAs can lead to a decrease of protein expression associated with some
forms of cancer. What could a drug do to counter this effect?
A. increase promoter activity of the miRNA genes
B. decrease expression of RNA polymerase
C. increase expression of RISC
, D. decrease expression of miRNA
Feedback: Learning Objective: Discuss how understanding regulation of gene expression can
lead to better drug design
Question 5 of 10
1.0/ 1.0 Points
What part of the ribosome is important in catalyzing peptide bonds?
A. the methyl guanosine cap
B. the rRNA
C. the ribosomal proteins
D. the E site
Feedback: Correct
Question 6 of 10
1.0/ 1.0 Points
is the first protein to bind to mRNA to being initiation of translation.
A. TFIIA
B. eIF-2
C. TFIID
D. 60S ribosomal subunit
E. 40S ribosomal subunit
Question 7 of 10
1.0/ 1.0 Points
Epigenetics refers to a special kind of hereditary mechanism. Epigenetic changes do not change
the DNA nucleotide sequence, yet their effect on gene expression can last for several
generations.
In one surprising study, it was found that the grandsons of men who suffered a famine were less
likely to die of cardiovascular disease. The experience of famine made some cardio-protective
change in the sperm of those grandfathers that was passed on.
What type of change was likely responsible?
A. histone acetylation or DNA methylation
B. transcription factor activity
C. ubiquitin tagging
D. phosphatase levels
Feedback: Learning Objective: Analyze the processes of gene expression and gene regulation
Question 8 of 10
0.0/ 1.0 Points
