Pathophysiology IThe IBiologic IBasis Ifor IDisease Iin IAdults Iand IChildren I8th IEdition I97803235834
Chapter 1 - Cellular Biology
I I I I 3
Chapter 2 - Altered Cellular and Tissue Biology Environmental Agents
I I I I I I I I I I IIIII 16 Chapter
I
I 3 - The Cellular Environment Fluids and Electrolytes Acids and
I I I I I I I I I
Bases 28
Chapter 4 - Genes and Genetic Diseases
I I I I I I III I 41
Chapter 5 - Genes Environment-Lifestyle and Common Diseases
I I I I I I I III I 51
Chapter 6 - Epigenetics and Disease
I I I I I III I 59
Chapter 7 - Innate Immunity Inflammation
I I I I I III I 64
Chapter 8 - Adaptive Immunity
I I I I III I 78
Chapter 9 - Alterations in Immunity and Inflammation
I I I I I I I 89
Chapter 10 - Infection I I I 102
Chapter 11 - Stress and Disease
I I I I I 110
Chapter 12 - Cancer Biology
I I I I I 117
Chapter 13 - Cancer Epidemiology
I I I I I 129
Chapter 14 - Cancer in Children
I I I I I I 135
Chapter 15 - Structure and Function of the Neurologic System
I I I I I I I I I I 140
Chapter 16 - Pain Temperature Regulation Sleep and Sensory Function 151
I I I I I I I I I I I
I Chapter 17 - Alterations in Cognitive Systems Cerebral Hemodynamics and
I I I I I I I I I
Motor Function I 165
Chapter 18 - Disorders of the Central and Peripheral Nervous Systems and
I I I I I I I I I I I
the Neuromuscular Junction
I I 179
Chapter 19 - Neurobiology of Schizophrenia Mood Disorders and Anxiety Disorders
I I I I I I I I I I I
189
Chapter 20 - Alterations of Neurologic Function in Children
I I I I I I I I 195
Chapter 21 - Mechanisms of Hormonal Regulation
I I I I I I I 202
Chapter 22 - Alterations of Hormonal Regulation
I I I I I I I 211
Chapter 23 - Obesity and Disorders of Nutrition NEW
I I I I I I I I I 223
Chapter 24 - Structure and Function of the Reproductive Systems
I I I I I I I I I I 228
Chapter 25 - Alterations of the Female Reproductive System
I I I I I I I I I 237
Chapter 26 - Alterations of the Male Reproductive System
I I I I I I I I I 246
,Pathophysiology IThe IBiologic IBasis Ifor IDisease Iin IAdults Iand IChildren I8th IEdition I97803235834
Chapter 27 - Sexually Transmitted Infections
I I I I I 252
Chapter 28 - Structure and Function of the Hematologic System
I I I I I I I I I I 260
Chapter 29 - Alterations of Erythrocyte Platelet and Hemostatic Function
I I I I I I I I I I 270
Chapter 30 - Alterations of Leukocyte and Lymphoid Function
I I I I I I I I I 280
Chapter 31 - Alterations of Hematologic Function in Children
I I I I I I I I I 287
Chapter 32 - Structure and Function of the Cardiovascular and Lymphatic
I I I I I I I I I I I
I Systems 297
Chapter 33 - Alterations of Cardiovascular Function
I I I I I I I 309
Chapter 34 - Alterations of Cardiovascular Function in Children
I I I I I I I I I 323
Chapter 35 - Structure and Function of the Pulmonary System
I I I I I I I I I I 331
Chapter 36 - Alterations of Pulmonary Function
I I I I I I I 341
Chapter 37 - Alterations of Pulmonary Function in Children
I I I I I I I I I 357
Chapter 38 - Structure and Function of the Renal and Urologic Systems
I I I I I I I I I I I I 365
Chapter 39 - Alterations of Renal and Urinary Function
I I I I I I I I I 375
Chapter 40 - Alterations of Renal and Urinary Tract Function in Children
I I I I I I I I I I I I 385
Chapter 41 - Structure and Function of the Digestive System
I I I I I I I I I I 393
Chapter 42 - Alterations of Digestive Function
I I I I I I I 404
Chapter 43 - Alterations of Digestive Function in Children
I I I I I I I I I 415
Chapter 44 - Structure and Function of the Musculoskeletal System
I I I I I I I I I I 424
Chapter 45 - Alterations of Musculoskeletal Function
I I I I I I I 436
Chapter 46 - Alterations of Musculoskeletal Function in Children
I I I I I I I I I 448
Chapter 47 - Structure Function and Disorders of the Integument
I I I I I I I I I I 457
Chapter 48 - Alterations of the Integument in Children
I I I I I I I I I 468
Chapter 49 - Shock Multiple Organ Dysfunction Syndrome and Burns in
I I I I I I I I I I I
Adults 476
Chapter 50 - Shock Multiple Organ Dysfunction Syndrome and Burns in
I I I I I I I I I I I
Children 483
,Pathophysiology IThe IBiologic IBasis Ifor IDisease Iin IAdults Iand IChildren I8th IEdition I97803235834
Chapter 01: Cellular Biology
I I I
McCance/Huether: Pathophysiology: The Biologic Basis of Disease in Adults and
I I I I I I I I I
Children, 8th Edition
I I I
MULTIPLE ICHOICE
1. Which Istatement Ibest Idescribes Ithe Icellular Ifunction Iof Imetabolic Iabsorption?
a. Cells Ican Iproduce Iproteins.
b. Cells Ican Isecrete Idigestive Ienzymes.
c. Cells Ican Itake Iin Iand Iuse Inutrients.
d. Cells Ican Isynthesize Ifats.
ANS: I C
In Imetabolic Iabsorption, Iall Icells Itake Iin Iand Iuse Inutrients Iand Iother Isubstances Ifrom Itheir
Isurroundings. IThe Iremaining Ioptions Iare Inot Iinclusive Iin Itheir Idescriptions Iof Icellular
Imetabolic Iabsorption.
PTS: I I I 1 DIF: Cognitive ILevel: IRemembering
2. Where Iis Imost Iof Ia Icell’s Igenetic Iinformation, Iincluding IRNA Iand IDNA, Icontained?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. Lysosome
ANS: I C
The Inucleus Icontains Ithe Inucleolus, Ia Ismall Idense Istructure Icomposed Ilargely Iof IRNA, Imost
Io f Ithe Icellular IDNA, Iand Ithe IDNA-binding Iproteins, Isuch Ias Ithe Ihistones, Iwhich Iregulate Iits
Iactivity. IThe Imitochondria Iare Iresponsible Ifor Icellular Irespiration Iand Ienergy Iproduction.
Ribosomes’ Ichief Ifunction Iis Ito Iprovide Isites Ifor Icellular Iprotein Isynthesis. ILysosomes
Ifunction Ias Ithe Iintracellular Idigestive Isystem.
PTS: I I I 1 DIF: Cognitive ILevel: IRemembering
3. Which Icomponent Iof Ithe Icell Iproduces Ihydrogen Iperoxide I(H2O2) Iby Iusing Ioxygen Ito Iremove
hydrogen Iatoms Ifrom Ispecific Isubstrates Iin Ian Ioxidative Ireaction?
I
a. Lysosomes
b. Peroxisomes
c. Ribosomes
d. Endosome
ANS: I B
Chapter I1 I- ICellular IBiology 3
, Pathophysiology IThe IBiologic IBasis Ifor IDisease Iin IAdults Iand IChildren I8th IEdition I97803235834
Peroxisomes Iare Iso Inamed Ibecause Ithey Iusually Icontain Ienzymes Ithat Iuse Ioxygen Ito Iremove
Ihydrogen Iatoms Ifrom Ispecific Isubstrates Iin Ian Ioxidative Ireaction Ithat Iproduces IH2O2, Iwhich Iis
Ia Ipowerful Ioxidant Iand Ipotentially Idestructive Iif Iit Iaccumulates Ior Iescapes Ifrom Iperoxisomes.
IRibosomes Iare IRNA-protein Icomplexes I(nucleoproteins) Ithat Iare Isynthesized Iin Ithe Inucleolus
Iand Isecreted Iinto Ithe Icytoplasm Ithrough Ipores Iin Ithe Inuclear Ienvelope Icalled Inuclear Ipore
Icomplexes. ILysosomes Iare Isaclike Istructures Ithat Ioriginate Ifrom Ithe IGolgi Icomplex Iand
Icontain Imore Ithan I40 Idigestive Ienzymes Icalled Ihydrolases, Iwhich Icatalyze Ibonds Iin Iproteins,
Ilipids, Inucleic Iacids, Iand Icarbohydrates. IAn Iendosome Iis Ia Ivesical Ithat Ihas Ibeen Ipinched Ioff
Ifrom Ithe Icellular Imembrane.
PTS: I I I 1 DIF: Cognitive ILevel: IRemembering
4. Which Icell Icomponent Iis Icapable Iof Icellular Iautodigestion Iwhen Iit Iis Ireleased Iduring Icell
injury?
I
a. Ribosome
b. Golgi Icomplex
c. Smooth Iendoplasmic Ireticulum
d. Lysosomes
ANS: I D
The Ilysosomal Imembrane Iacts Ias Ia Iprotective Ishield Ibetween Ithe Ipowerful Idigestive Ienzymes
Iw ithin Ithe Ilysosome Iand Ithe Icytoplasm, Ipreventing Itheir Ileakage Iinto Ithe Icytoplasmic Imatrix.
ID isruption Iof Ithe Imembrane Iby Ivarious Itreatments Ior Icellular Iinjury Ileads Ito Ia Irelease Iof Ithe
Ilysosomal Ienzymes, Iwhich Ican Ithen Ireact Iwith Itheir Ispecific Isubstrates, Icausing Icellular
self-digestion. IThe Ichief Ifunction Iof Ia Iribosome Iis Ito Iprovide Isites Ifor Icellular Iprotein
Isynthesis. IThe IGolgi Icomplex Iis Ia Inetwork Iof Iflattened, Ismooth Ivesicles Iand Imembranes Ioften
Ilocated Inear Ithe Icell Inucleus. IThe Ismooth Iendoplasmic Ireticulum Iis Iinvolved Iin Isteroid
Ihormone Iproduction Iand Iremoving Itoxic Isubstances Ifrom Ithe Icell.
PTS: I I I 1 DIF: Cognitive ILevel: IRemembering
5. Which IcAMP-mediated Iresponse Iis Irelated Ito Iantidiuretic Ihormone?
a. Increased Iheart Irate Iand Iforce Iof Icontraction
b. Secretion Iof Icortisol
c. Increased Iretention Iof Iwater
d. Breakdown Iof Ifat
ANS: I C
Antidiuretic Ihormone Ileads Ito Iincreased Iretention Iof Iwater Iin Ithe Ibody. IEpinephrine Icauses
Iincreases Iin Iheart Irate Iand Iforce Iof Icontraction. IIncreased Icortisol Isecretion Iis Idue Ito IACTH.
IBreakdown Iof Ifat Iis Idue Ito Iglucagon.
PTS: I I I 1 DIF: Cognitive ILevel: IRemembering
6. During Iwhich Iphase Iof Ithe Icell Icycle Iis IDNA Isynthesized?
a. G1
b. S
c. G2
d. M
ANS: I B
Chapter I1 I- ICellular IBiology 4
Chapter 1 - Cellular Biology
I I I I 3
Chapter 2 - Altered Cellular and Tissue Biology Environmental Agents
I I I I I I I I I I IIIII 16 Chapter
I
I 3 - The Cellular Environment Fluids and Electrolytes Acids and
I I I I I I I I I
Bases 28
Chapter 4 - Genes and Genetic Diseases
I I I I I I III I 41
Chapter 5 - Genes Environment-Lifestyle and Common Diseases
I I I I I I I III I 51
Chapter 6 - Epigenetics and Disease
I I I I I III I 59
Chapter 7 - Innate Immunity Inflammation
I I I I I III I 64
Chapter 8 - Adaptive Immunity
I I I I III I 78
Chapter 9 - Alterations in Immunity and Inflammation
I I I I I I I 89
Chapter 10 - Infection I I I 102
Chapter 11 - Stress and Disease
I I I I I 110
Chapter 12 - Cancer Biology
I I I I I 117
Chapter 13 - Cancer Epidemiology
I I I I I 129
Chapter 14 - Cancer in Children
I I I I I I 135
Chapter 15 - Structure and Function of the Neurologic System
I I I I I I I I I I 140
Chapter 16 - Pain Temperature Regulation Sleep and Sensory Function 151
I I I I I I I I I I I
I Chapter 17 - Alterations in Cognitive Systems Cerebral Hemodynamics and
I I I I I I I I I
Motor Function I 165
Chapter 18 - Disorders of the Central and Peripheral Nervous Systems and
I I I I I I I I I I I
the Neuromuscular Junction
I I 179
Chapter 19 - Neurobiology of Schizophrenia Mood Disorders and Anxiety Disorders
I I I I I I I I I I I
189
Chapter 20 - Alterations of Neurologic Function in Children
I I I I I I I I 195
Chapter 21 - Mechanisms of Hormonal Regulation
I I I I I I I 202
Chapter 22 - Alterations of Hormonal Regulation
I I I I I I I 211
Chapter 23 - Obesity and Disorders of Nutrition NEW
I I I I I I I I I 223
Chapter 24 - Structure and Function of the Reproductive Systems
I I I I I I I I I I 228
Chapter 25 - Alterations of the Female Reproductive System
I I I I I I I I I 237
Chapter 26 - Alterations of the Male Reproductive System
I I I I I I I I I 246
,Pathophysiology IThe IBiologic IBasis Ifor IDisease Iin IAdults Iand IChildren I8th IEdition I97803235834
Chapter 27 - Sexually Transmitted Infections
I I I I I 252
Chapter 28 - Structure and Function of the Hematologic System
I I I I I I I I I I 260
Chapter 29 - Alterations of Erythrocyte Platelet and Hemostatic Function
I I I I I I I I I I 270
Chapter 30 - Alterations of Leukocyte and Lymphoid Function
I I I I I I I I I 280
Chapter 31 - Alterations of Hematologic Function in Children
I I I I I I I I I 287
Chapter 32 - Structure and Function of the Cardiovascular and Lymphatic
I I I I I I I I I I I
I Systems 297
Chapter 33 - Alterations of Cardiovascular Function
I I I I I I I 309
Chapter 34 - Alterations of Cardiovascular Function in Children
I I I I I I I I I 323
Chapter 35 - Structure and Function of the Pulmonary System
I I I I I I I I I I 331
Chapter 36 - Alterations of Pulmonary Function
I I I I I I I 341
Chapter 37 - Alterations of Pulmonary Function in Children
I I I I I I I I I 357
Chapter 38 - Structure and Function of the Renal and Urologic Systems
I I I I I I I I I I I I 365
Chapter 39 - Alterations of Renal and Urinary Function
I I I I I I I I I 375
Chapter 40 - Alterations of Renal and Urinary Tract Function in Children
I I I I I I I I I I I I 385
Chapter 41 - Structure and Function of the Digestive System
I I I I I I I I I I 393
Chapter 42 - Alterations of Digestive Function
I I I I I I I 404
Chapter 43 - Alterations of Digestive Function in Children
I I I I I I I I I 415
Chapter 44 - Structure and Function of the Musculoskeletal System
I I I I I I I I I I 424
Chapter 45 - Alterations of Musculoskeletal Function
I I I I I I I 436
Chapter 46 - Alterations of Musculoskeletal Function in Children
I I I I I I I I I 448
Chapter 47 - Structure Function and Disorders of the Integument
I I I I I I I I I I 457
Chapter 48 - Alterations of the Integument in Children
I I I I I I I I I 468
Chapter 49 - Shock Multiple Organ Dysfunction Syndrome and Burns in
I I I I I I I I I I I
Adults 476
Chapter 50 - Shock Multiple Organ Dysfunction Syndrome and Burns in
I I I I I I I I I I I
Children 483
,Pathophysiology IThe IBiologic IBasis Ifor IDisease Iin IAdults Iand IChildren I8th IEdition I97803235834
Chapter 01: Cellular Biology
I I I
McCance/Huether: Pathophysiology: The Biologic Basis of Disease in Adults and
I I I I I I I I I
Children, 8th Edition
I I I
MULTIPLE ICHOICE
1. Which Istatement Ibest Idescribes Ithe Icellular Ifunction Iof Imetabolic Iabsorption?
a. Cells Ican Iproduce Iproteins.
b. Cells Ican Isecrete Idigestive Ienzymes.
c. Cells Ican Itake Iin Iand Iuse Inutrients.
d. Cells Ican Isynthesize Ifats.
ANS: I C
In Imetabolic Iabsorption, Iall Icells Itake Iin Iand Iuse Inutrients Iand Iother Isubstances Ifrom Itheir
Isurroundings. IThe Iremaining Ioptions Iare Inot Iinclusive Iin Itheir Idescriptions Iof Icellular
Imetabolic Iabsorption.
PTS: I I I 1 DIF: Cognitive ILevel: IRemembering
2. Where Iis Imost Iof Ia Icell’s Igenetic Iinformation, Iincluding IRNA Iand IDNA, Icontained?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. Lysosome
ANS: I C
The Inucleus Icontains Ithe Inucleolus, Ia Ismall Idense Istructure Icomposed Ilargely Iof IRNA, Imost
Io f Ithe Icellular IDNA, Iand Ithe IDNA-binding Iproteins, Isuch Ias Ithe Ihistones, Iwhich Iregulate Iits
Iactivity. IThe Imitochondria Iare Iresponsible Ifor Icellular Irespiration Iand Ienergy Iproduction.
Ribosomes’ Ichief Ifunction Iis Ito Iprovide Isites Ifor Icellular Iprotein Isynthesis. ILysosomes
Ifunction Ias Ithe Iintracellular Idigestive Isystem.
PTS: I I I 1 DIF: Cognitive ILevel: IRemembering
3. Which Icomponent Iof Ithe Icell Iproduces Ihydrogen Iperoxide I(H2O2) Iby Iusing Ioxygen Ito Iremove
hydrogen Iatoms Ifrom Ispecific Isubstrates Iin Ian Ioxidative Ireaction?
I
a. Lysosomes
b. Peroxisomes
c. Ribosomes
d. Endosome
ANS: I B
Chapter I1 I- ICellular IBiology 3
, Pathophysiology IThe IBiologic IBasis Ifor IDisease Iin IAdults Iand IChildren I8th IEdition I97803235834
Peroxisomes Iare Iso Inamed Ibecause Ithey Iusually Icontain Ienzymes Ithat Iuse Ioxygen Ito Iremove
Ihydrogen Iatoms Ifrom Ispecific Isubstrates Iin Ian Ioxidative Ireaction Ithat Iproduces IH2O2, Iwhich Iis
Ia Ipowerful Ioxidant Iand Ipotentially Idestructive Iif Iit Iaccumulates Ior Iescapes Ifrom Iperoxisomes.
IRibosomes Iare IRNA-protein Icomplexes I(nucleoproteins) Ithat Iare Isynthesized Iin Ithe Inucleolus
Iand Isecreted Iinto Ithe Icytoplasm Ithrough Ipores Iin Ithe Inuclear Ienvelope Icalled Inuclear Ipore
Icomplexes. ILysosomes Iare Isaclike Istructures Ithat Ioriginate Ifrom Ithe IGolgi Icomplex Iand
Icontain Imore Ithan I40 Idigestive Ienzymes Icalled Ihydrolases, Iwhich Icatalyze Ibonds Iin Iproteins,
Ilipids, Inucleic Iacids, Iand Icarbohydrates. IAn Iendosome Iis Ia Ivesical Ithat Ihas Ibeen Ipinched Ioff
Ifrom Ithe Icellular Imembrane.
PTS: I I I 1 DIF: Cognitive ILevel: IRemembering
4. Which Icell Icomponent Iis Icapable Iof Icellular Iautodigestion Iwhen Iit Iis Ireleased Iduring Icell
injury?
I
a. Ribosome
b. Golgi Icomplex
c. Smooth Iendoplasmic Ireticulum
d. Lysosomes
ANS: I D
The Ilysosomal Imembrane Iacts Ias Ia Iprotective Ishield Ibetween Ithe Ipowerful Idigestive Ienzymes
Iw ithin Ithe Ilysosome Iand Ithe Icytoplasm, Ipreventing Itheir Ileakage Iinto Ithe Icytoplasmic Imatrix.
ID isruption Iof Ithe Imembrane Iby Ivarious Itreatments Ior Icellular Iinjury Ileads Ito Ia Irelease Iof Ithe
Ilysosomal Ienzymes, Iwhich Ican Ithen Ireact Iwith Itheir Ispecific Isubstrates, Icausing Icellular
self-digestion. IThe Ichief Ifunction Iof Ia Iribosome Iis Ito Iprovide Isites Ifor Icellular Iprotein
Isynthesis. IThe IGolgi Icomplex Iis Ia Inetwork Iof Iflattened, Ismooth Ivesicles Iand Imembranes Ioften
Ilocated Inear Ithe Icell Inucleus. IThe Ismooth Iendoplasmic Ireticulum Iis Iinvolved Iin Isteroid
Ihormone Iproduction Iand Iremoving Itoxic Isubstances Ifrom Ithe Icell.
PTS: I I I 1 DIF: Cognitive ILevel: IRemembering
5. Which IcAMP-mediated Iresponse Iis Irelated Ito Iantidiuretic Ihormone?
a. Increased Iheart Irate Iand Iforce Iof Icontraction
b. Secretion Iof Icortisol
c. Increased Iretention Iof Iwater
d. Breakdown Iof Ifat
ANS: I C
Antidiuretic Ihormone Ileads Ito Iincreased Iretention Iof Iwater Iin Ithe Ibody. IEpinephrine Icauses
Iincreases Iin Iheart Irate Iand Iforce Iof Icontraction. IIncreased Icortisol Isecretion Iis Idue Ito IACTH.
IBreakdown Iof Ifat Iis Idue Ito Iglucagon.
PTS: I I I 1 DIF: Cognitive ILevel: IRemembering
6. During Iwhich Iphase Iof Ithe Icell Icycle Iis IDNA Isynthesized?
a. G1
b. S
c. G2
d. M
ANS: I B
Chapter I1 I- ICellular IBiology 4
