BioChem C785 - WGU - Module 3 - all questions

BioChem C785 - WGU - Module 3 - all questionsBioChem C785 - WGU - Module 3 - all questions Hb (hemoglobin) binds to CO (carbon monoxide) with a higher affinity than oxygen and stabilizes the R (relaxed) state ANSWERS: True When hemoglobin changes from the T to the R, it has a high affinity for oxygen ANSWERS: True When hemoglobin changes from the R to T, it has a low affinity for oxygen ANSWERS: True Cooperatively refers to ANSWERS: structural changes that increases the affinity for oxygen in hemoglobin When the oxygen concentration is high, the heme shape is planar. When the oxygen concentration is low, the heme shape is bent shape. ANSWERS: True The Bohr effect is a relationship between hemoglobin's oxygen binding behavior in conjunction with the pH of the surroundings. When the pH is low, hemoglobin has low affinity for oxygen and releases oxygen ANSWERS: True Bohr effect is a relationship between hemoglobin's oxygen binding behavior in conjunction with the pH of the surroundings. When the pH is high, hemoglobin has high affinity for oxygen and binds oxygen. ANSWERS: True Relative to the lungs, the pH in the peripheral tissues is lower, because the CO2 generated by metabolism is converted to bicarbonate, which releases proton (H+)ANSWERS: True The Bohr effect is a relationship between hemoglobin's oxygen binding behavior in conjunction with the pH of the surroundings. When the H+ ion concentration increases, the pH of the solution decreases. ANSWERS: True Myoglobin stores oxygen, whereas hemoglobin transports oxygen. Myoglobin has a higher affinity for oxygen compared to hemoglobin ANSWERS: TrueHemoglobin is an oxygen transport protein, whereas myoglobin is an oxygen storage protein. They exhibit different binding curves when plotted on a graph with total partial pressure of the oxygen (xaxis) plotted against the percentage saturation of hemoglobin (y-axis). What pattern of binding curves do these proteins exhibit? ANSWERS: Hemoglobin has a sigmoidal curve whereas the myoglobin has a hyperbolic curve. Hemoglobin and myoglobin proteins bind to molecular oxygen. However, the protein part of the hemoglobin does not bind directly to the oxygen. Instead a specific atom helps bind the oxygen - ANSWERS: Iron The symptoms of sickle cell anemia are primarily because red blood cells are misshaped, due to ANSWERS: a mutation in the beta hemoglobin gene which leads to the insertion of valine into the hydrophobic patches on deoxygenated hemoglobin Relative to the peripheral tissues, the pH in lungs is higher, because ANSWERS: the protons (H+) that were combined with hemoglobin quickly bind to bicarbonate (HCO3-) to form CO2; the CO2 is then exhaled Why is carbon monoxide poisonous? ANSWERS: it binds hemoglobin 200 times better than oxygen BPG stabilizes the T (tense) states of hemoglobin ANSWERS: True