Pathology general white blood questions and answers 2022.

PATHOLOGY GENERAL WHITE BLOOD QUESTIONS AND ANSWERS 2022

1. What mature blood cells do myeloid stem cells produce? Lymphoid stem
cells?: Myeloid stem cells produce:
Neutrophils;
Eosinophils;
Basophils:
Mast cells;
Monocytes(macrophages);
Platelets;
Erythrocytes (RBCs);
Lymphoid stem cells produce:
CD-4 cells;
CD-8 cells;
NK cells;
B cells
2. No matter the type of leukemia, overcrowding of the bone marrow by
malignant
leukemia cells result in what three clinical manisfestations?: Anemia (due to
reduced RBC production);
Chronic infections (due to reduced number of all white blood cell
production);
Bruising and bleeding complications (due to reduced platelet production).
3. Distinguish between acute and chronic leukemia in terms of age of onset,
maturity
of cells, and onset of treatment.: . Acute Leukemia;
Rapid growth of immature blood cells (blast cells);
Mostly occurs in children, adolescents and young adults;
Treatment must be immediate and strong.
Chronic Leukemia:
Slow growth of more developed or mature cells;
Mostly occurs in adults > 50 years of age;
Treatment depends on stage, but usually less aggressive
4. How common is Acute lymphoblastic leukemia (ALL) in terms of pediatric
cancers? In most cases, what is the pathophysiology of the transformed
lymphoid


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, cells? What environmental factors usually causes this transformation? What
historical events clearly linked radiation exposure to leukemia?: Most com-
mon malignancy diagnosed in children, representing nearly one third
of all pediatric cancers;




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