Cannabinoids and Its Impact on Mental Health
Cannabis has been used for medicinal and psychoactive properties used by an
approximate 13 million people, who identify as cannabis dependent. Through consequent
explorations by microbiologists and researchers, cannabis was discovered to have many
medicinal properties and consequently made a mark in the medical department. A drug that was
believed to be a source of mental retardation surprisingly turned out to be the one to cure mental
illnesses. It begins in the primary compound that holds psychoactive properties, delta-9-
tetrahydrcannabinol, which is commonly known as THC. THC acts within the cannabinoid
system in the brain, of exogenous and endogenous cannabinoids along their receptors. The
exogenous cannabinoids of which THC acts via is through the cannabinoid receptors, CB1 and
CB2. Both cannabinoid receptors are found in the central and peripheral nervous systems and
immune system work together to determine how endocannabinoids or endogenous cannabinoids,
AEA and 2-AG, interact within the body. CB1 receptors, which are G protein-coupled
cannabinoid receptors, could be found in the brain and spinal cord and play an important role in
memory and emotional
regulation. CB2, found in
the nervous system, have a
role of helping to modulate
inflammation, pain
management, and
inflammation. They work
together to bind with AEA and 2-AG, which serve a purpose as endogenous agonists of CBRs, to
bring homeostasis within the body and is believed by psychiatrists to potentially help with
, mental health. However, the use of cannabinoids has been known to cause several symptoms
such as psychomotor dysfunction, short-term memory impairment, and intoxication, in addition
to possessing antinociceptive and antiemetic qualities. It has been shown that chronic cannabis
users have mild cognitive impairment. Still, there is no evidence that these deficiencies are
permanent or accompanied by drug-induced neuropathology. Reports indicate that a small
proportion of regular cannabis users develop a tolerance to the drug and become dependent on it.
In certain studies, chronic cannabis use has been linked to an increased chance of developing
mental health issues. However, there is inadequate data to substantiate this relationship at
present. The present study will examine the relationship between cannabinoids and its impact on
mental health.
Cannabidiol (CBD) is a notable chemical found in the cannabis sativa plant, which is
known today to be as cannabis or hemp. Of this cannabis sativa plant, there is over 80 chemicals,
known as cannabinoids, which are found to have the potential of becoming a beneficial
component in easing such psychiatric disorders. One of these psychiatric disorders is most
commonly found in 21.0 million adults in the United States is depression. It has been suggested
for CBD to have the possibility of inducing antidepressant-like effects as shown in preclinical
studies. Discussing the mechanisms of the affect of cannabis onto depression, is based upon the
balance needed for a normal mood by the neuronal signaling pathways: norepinephrine,
dopamine, and serotonin. Each of these signaling pathways have an important role when it comes
to emotional regulation, stress response, and the depression neurobiology. Traditionally, these
are treated by the following antidepressants: selective serotonin reuptake inhibitors (SSI) and
tricyclic drugs, as they prevent the reabsorption of the neurotransmitters, serotonin (and for
tricyclic, both serotonin and norepinephrine), and enhance the concentration of them in the
Cannabis has been used for medicinal and psychoactive properties used by an
approximate 13 million people, who identify as cannabis dependent. Through consequent
explorations by microbiologists and researchers, cannabis was discovered to have many
medicinal properties and consequently made a mark in the medical department. A drug that was
believed to be a source of mental retardation surprisingly turned out to be the one to cure mental
illnesses. It begins in the primary compound that holds psychoactive properties, delta-9-
tetrahydrcannabinol, which is commonly known as THC. THC acts within the cannabinoid
system in the brain, of exogenous and endogenous cannabinoids along their receptors. The
exogenous cannabinoids of which THC acts via is through the cannabinoid receptors, CB1 and
CB2. Both cannabinoid receptors are found in the central and peripheral nervous systems and
immune system work together to determine how endocannabinoids or endogenous cannabinoids,
AEA and 2-AG, interact within the body. CB1 receptors, which are G protein-coupled
cannabinoid receptors, could be found in the brain and spinal cord and play an important role in
memory and emotional
regulation. CB2, found in
the nervous system, have a
role of helping to modulate
inflammation, pain
management, and
inflammation. They work
together to bind with AEA and 2-AG, which serve a purpose as endogenous agonists of CBRs, to
bring homeostasis within the body and is believed by psychiatrists to potentially help with
, mental health. However, the use of cannabinoids has been known to cause several symptoms
such as psychomotor dysfunction, short-term memory impairment, and intoxication, in addition
to possessing antinociceptive and antiemetic qualities. It has been shown that chronic cannabis
users have mild cognitive impairment. Still, there is no evidence that these deficiencies are
permanent or accompanied by drug-induced neuropathology. Reports indicate that a small
proportion of regular cannabis users develop a tolerance to the drug and become dependent on it.
In certain studies, chronic cannabis use has been linked to an increased chance of developing
mental health issues. However, there is inadequate data to substantiate this relationship at
present. The present study will examine the relationship between cannabinoids and its impact on
mental health.
Cannabidiol (CBD) is a notable chemical found in the cannabis sativa plant, which is
known today to be as cannabis or hemp. Of this cannabis sativa plant, there is over 80 chemicals,
known as cannabinoids, which are found to have the potential of becoming a beneficial
component in easing such psychiatric disorders. One of these psychiatric disorders is most
commonly found in 21.0 million adults in the United States is depression. It has been suggested
for CBD to have the possibility of inducing antidepressant-like effects as shown in preclinical
studies. Discussing the mechanisms of the affect of cannabis onto depression, is based upon the
balance needed for a normal mood by the neuronal signaling pathways: norepinephrine,
dopamine, and serotonin. Each of these signaling pathways have an important role when it comes
to emotional regulation, stress response, and the depression neurobiology. Traditionally, these
are treated by the following antidepressants: selective serotonin reuptake inhibitors (SSI) and
tricyclic drugs, as they prevent the reabsorption of the neurotransmitters, serotonin (and for
tricyclic, both serotonin and norepinephrine), and enhance the concentration of them in the
