Study Guide
1
NR 292 STUDY GUIDE EXAM II WITH
ANSWERS
50 Questions – Multiple Choice, Select All That Apply, Multiple Sequence
Chapter 30: Pituitary Drugs
Therapy is lifelong
Examples of drugs
o Anterior: Cosyntropin, Somatropin, Somatrem, Octreotide
Cosyntropin: synthetic cortisol – used in diagnosis of adrenal
insufficiency, stimulates release of cortisol from adrenal cortex, cortisol
has anti-inflammatory effect and renal retention of sodium
Somatropin and Somatrem: mimic Growth Hormone, effects on skeletal
and cellular growth (stimulate skeletal growth in pts with deficient GH
such as hypopituitary and dwarfism, replacement for adults with
pituitary disease
Octreotide: antagonizes the effects of GH by inhibiting release, decrease
plasma concentrations of vasoactive intestinal polypeptide (reduces
severe diarrhea associated with VIP tumors), also used to treat
esophageal varices
o Posterior: Vasopressin, Desmopressin, Oxytocin
Desmopressin: increases factor VIII – useful for some bleeding
disorders, nocturnal enuresis, diabetes insipidus
Vasopressin: potent vasoconstrictor in large doses – hypotensive crisis,
esophageal varices, diabetes insipidus
Oxytocin: mimics uterine contractions by stimulating uterine smooth
muscle, used for induction of labor and postpartum bleeding,
vasopressor and antidiuretic effects
Got to Know
o Octreotide
Suppresses secretion of GH, insulin, and glucagon
Used for diarrhea management for pts with AIDS
Can cause hypotension r/t reabsorption of fluids/electrolytes
o Vasopressin & Desmopressin
Avoid used of alcohol as it decreases ADH hormone effect
Monitor for s/s of hypervolemia
, Study Guide
2
o Somatropin
Maintain growth chart for children being treated for primary dwarfism
Chapter 31: Thyroid and Antithyroid Drugs
Thyroid Replacement Drugs
o Natural – dessicated (dried up animal T3&T4): not as predictable and not as
commonly used
Hyperthyroid Drugs: Methimazole, Propylthiouracil
o Methimazole blocks iodine from getting to the thyroid so less T3 and T4 is made
Got to Know
o Levothyroxine
TSH is high when thyroid function is low
Full effects may not be felt for up to 3-4 weeks
Once daily dosing due to long half life
Dose in AM due to insomnia (same time each day)
Take on empty stomach with full glass of water
^metabolism = ^HR = ^O2 demand = ^ risk for cardiac issues
^ blood glucose levels and interferes with: insulin, oral antidiabetics,
digoxin, phenytoin, phenobarbital (highly protein bound meds)
o Methiamazole & Propylthiouracil (PTU)
May cause drowsiness
Can cause liver toxicity – monitor LFTs
May cause bone marrow suppression
Avoid foods containing Iodine (seafood, soy sauce, tofu, and iodized
salt)
o Levothyroxine is measured in mcg and Dessicated is measured in mg
1
NR 292 STUDY GUIDE EXAM II WITH
ANSWERS
50 Questions – Multiple Choice, Select All That Apply, Multiple Sequence
Chapter 30: Pituitary Drugs
Therapy is lifelong
Examples of drugs
o Anterior: Cosyntropin, Somatropin, Somatrem, Octreotide
Cosyntropin: synthetic cortisol – used in diagnosis of adrenal
insufficiency, stimulates release of cortisol from adrenal cortex, cortisol
has anti-inflammatory effect and renal retention of sodium
Somatropin and Somatrem: mimic Growth Hormone, effects on skeletal
and cellular growth (stimulate skeletal growth in pts with deficient GH
such as hypopituitary and dwarfism, replacement for adults with
pituitary disease
Octreotide: antagonizes the effects of GH by inhibiting release, decrease
plasma concentrations of vasoactive intestinal polypeptide (reduces
severe diarrhea associated with VIP tumors), also used to treat
esophageal varices
o Posterior: Vasopressin, Desmopressin, Oxytocin
Desmopressin: increases factor VIII – useful for some bleeding
disorders, nocturnal enuresis, diabetes insipidus
Vasopressin: potent vasoconstrictor in large doses – hypotensive crisis,
esophageal varices, diabetes insipidus
Oxytocin: mimics uterine contractions by stimulating uterine smooth
muscle, used for induction of labor and postpartum bleeding,
vasopressor and antidiuretic effects
Got to Know
o Octreotide
Suppresses secretion of GH, insulin, and glucagon
Used for diarrhea management for pts with AIDS
Can cause hypotension r/t reabsorption of fluids/electrolytes
o Vasopressin & Desmopressin
Avoid used of alcohol as it decreases ADH hormone effect
Monitor for s/s of hypervolemia
, Study Guide
2
o Somatropin
Maintain growth chart for children being treated for primary dwarfism
Chapter 31: Thyroid and Antithyroid Drugs
Thyroid Replacement Drugs
o Natural – dessicated (dried up animal T3&T4): not as predictable and not as
commonly used
Hyperthyroid Drugs: Methimazole, Propylthiouracil
o Methimazole blocks iodine from getting to the thyroid so less T3 and T4 is made
Got to Know
o Levothyroxine
TSH is high when thyroid function is low
Full effects may not be felt for up to 3-4 weeks
Once daily dosing due to long half life
Dose in AM due to insomnia (same time each day)
Take on empty stomach with full glass of water
^metabolism = ^HR = ^O2 demand = ^ risk for cardiac issues
^ blood glucose levels and interferes with: insulin, oral antidiabetics,
digoxin, phenytoin, phenobarbital (highly protein bound meds)
o Methiamazole & Propylthiouracil (PTU)
May cause drowsiness
Can cause liver toxicity – monitor LFTs
May cause bone marrow suppression
Avoid foods containing Iodine (seafood, soy sauce, tofu, and iodized
salt)
o Levothyroxine is measured in mcg and Dessicated is measured in mg
