N5315- HEMOSTASIS PART II QUESTIONS & ANSWERS
1. What is the 2nd arm of hemostasis? The coagulation cascade
2. How many coagulation factors are there? 12
3. What are the coagulation factors made of? They are plasma proteins; most produced in
the liver
4. How are the coagulation factors named? In order of discovery.
5. What are coagulation factors in an inactive form? Zymogens
6. How is an activated zymogen noted as? With a after factor roman numeral (ex. Va is
activated factor V).
7. What is considered the primary pathway of coagulation? Extrinsic pathway
8. When is the extrinsic pathway activated? When Tissue Factor is exposed at the site of
injury
9. What is the process of the extrinsic pathway? Tissue Factor (III) exposed; binds with VII
to form TF/VIIa complex; TF/VIIa activates X-Xa; Xa binds with Va and calcium to
form prothrombinase complex; prothrombinase complex converts factor II (prothrombin)
to IIa (thrombin); IIa then activates 4 factos (I – fibrinogen to Ia – fibrin; factors V, VIII
and XIII); fibrin (Ia) placed over platelet plug and XIIIa stabilizes the fibrin
10. Does a deficiency in factor XII (Hageman factor) cause bleeding? No
11. What is the main function of the intrinsic pathway? To enhance the extrinsic pathway
12. When is the intrinsic pathway activated? When the blood is exposed to negative charges
which are found on the molecules of ADP and ATP.
1. What is the 2nd arm of hemostasis? The coagulation cascade
2. How many coagulation factors are there? 12
3. What are the coagulation factors made of? They are plasma proteins; most produced in
the liver
4. How are the coagulation factors named? In order of discovery.
5. What are coagulation factors in an inactive form? Zymogens
6. How is an activated zymogen noted as? With a after factor roman numeral (ex. Va is
activated factor V).
7. What is considered the primary pathway of coagulation? Extrinsic pathway
8. When is the extrinsic pathway activated? When Tissue Factor is exposed at the site of
injury
9. What is the process of the extrinsic pathway? Tissue Factor (III) exposed; binds with VII
to form TF/VIIa complex; TF/VIIa activates X-Xa; Xa binds with Va and calcium to
form prothrombinase complex; prothrombinase complex converts factor II (prothrombin)
to IIa (thrombin); IIa then activates 4 factos (I – fibrinogen to Ia – fibrin; factors V, VIII
and XIII); fibrin (Ia) placed over platelet plug and XIIIa stabilizes the fibrin
10. Does a deficiency in factor XII (Hageman factor) cause bleeding? No
11. What is the main function of the intrinsic pathway? To enhance the extrinsic pathway
12. When is the intrinsic pathway activated? When the blood is exposed to negative charges
which are found on the molecules of ADP and ATP.
