Select the correct statement about the enzymes referred to as cyclooxygenase (COX).
Select one:
a. Cyclooxygenase (COX) increases uric acid production and deposition in the joints, leading to
gout.
b. Cyclooxygenase makes various prostaglandins needed from arachidonic acid.
c. Cyclooxygenase production is stimulated with NSAID use.
d. None of these are correct.
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The correct answer is: Cyclooxygenase makes various prostaglandins needed from arachidonic
acid.
Question2
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Select the statement that best explains why acetaminophen is effective in the treatment of headache
pains but not effective in the treatment of muscle aches and inflammation.
Select one:
a. Acetaminophen is effective against the pain of headache because it inhibits prostaglandin
synthesis within the CNS but does not significantly inhibit the synthesis of prostaglandins in
peripheral systems, which accounts for the lack of antiinflammatory activity.
,b. Acetaminophen is effective against the pain of headache because it stimulates prostaglandin
synthesis within the CNS but does not significantly inhibit the synthesis of prostaglandins in
peripheral systems, which accounts for the lack of antiinflammatory activity.
c. Acetaminophen is effective against the pain of headache because it stimulates prostaglandin
synthesis within the CNS but does not affect platelet aggregation or prothrombin time, which
accounts for the lack of antiinflammatory activity.
d. None of these are correct.
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The correct answer is: Acetaminophen is effective against the pain of headache because it inhibits
prostaglandin synthesis within the CNS but does not significantly inhibit the synthesis of
prostaglandins in peripheral systems, which accounts for the lack of antiinflammatory activity.
Question3
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Use the clinical indications for the use of nonsteroidal antiinflammatory drugs to select the true
statement about their use.
Select one:
a. Nonsteroidal antiinflammatory drugs are approved for the relief of pain arising from local
inflammatory responses including headache, dental extraction, soft tissue injury, sunburn,
musculoskeletal, and joint overexertion and strain.
b. Because of the direct action on regional prostaglandin production, NSAIDs are indicated for the
chronic treatment of dysmenorrhea and for controlling the signs and symptoms of osteo and
rheumatoid arthritis.
, c. Nonsteroidal antiinflammatory drugs are approved for the relief of mild to moderate pain where
opioids are not indicated or warranted.
d. All of these are true.
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The correct answer is: All of these are true.
Question4
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Mu receptors have _____ ion channels which will be _____, thereby decreasing the release of
neurotransmitters associated with pain.
Select one:
a. K, stimulated
b. K, blocked
c. Ca, stimulated
d. Ca, blocked
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The correct answer is: Ca, blocked
Question5
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Select one:
a. Cyclooxygenase (COX) increases uric acid production and deposition in the joints, leading to
gout.
b. Cyclooxygenase makes various prostaglandins needed from arachidonic acid.
c. Cyclooxygenase production is stimulated with NSAID use.
d. None of these are correct.
Feedback
The correct answer is: Cyclooxygenase makes various prostaglandins needed from arachidonic
acid.
Question2
Correct
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Question text
Select the statement that best explains why acetaminophen is effective in the treatment of headache
pains but not effective in the treatment of muscle aches and inflammation.
Select one:
a. Acetaminophen is effective against the pain of headache because it inhibits prostaglandin
synthesis within the CNS but does not significantly inhibit the synthesis of prostaglandins in
peripheral systems, which accounts for the lack of antiinflammatory activity.
,b. Acetaminophen is effective against the pain of headache because it stimulates prostaglandin
synthesis within the CNS but does not significantly inhibit the synthesis of prostaglandins in
peripheral systems, which accounts for the lack of antiinflammatory activity.
c. Acetaminophen is effective against the pain of headache because it stimulates prostaglandin
synthesis within the CNS but does not affect platelet aggregation or prothrombin time, which
accounts for the lack of antiinflammatory activity.
d. None of these are correct.
Feedback
The correct answer is: Acetaminophen is effective against the pain of headache because it inhibits
prostaglandin synthesis within the CNS but does not significantly inhibit the synthesis of
prostaglandins in peripheral systems, which accounts for the lack of antiinflammatory activity.
Question3
Correct
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Question text
Use the clinical indications for the use of nonsteroidal antiinflammatory drugs to select the true
statement about their use.
Select one:
a. Nonsteroidal antiinflammatory drugs are approved for the relief of pain arising from local
inflammatory responses including headache, dental extraction, soft tissue injury, sunburn,
musculoskeletal, and joint overexertion and strain.
b. Because of the direct action on regional prostaglandin production, NSAIDs are indicated for the
chronic treatment of dysmenorrhea and for controlling the signs and symptoms of osteo and
rheumatoid arthritis.
, c. Nonsteroidal antiinflammatory drugs are approved for the relief of mild to moderate pain where
opioids are not indicated or warranted.
d. All of these are true.
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The correct answer is: All of these are true.
Question4
Correct
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Question text
Mu receptors have _____ ion channels which will be _____, thereby decreasing the release of
neurotransmitters associated with pain.
Select one:
a. K, stimulated
b. K, blocked
c. Ca, stimulated
d. Ca, blocked
Feedback
The correct answer is: Ca, blocked
Question5
Correct
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