T Cell Developmental Biology
Hematopoietic stem cells gain Lineage specificcharacteristics
Functionalplasticity
Diff effectorsubtypes
Major Landmarks Repertoire selection checkpoints
to eliminate non functional or selfreactiveTors
TCR x Ry V J recombination
V D J recombination
p es
D4 Linear monomeric Igstmolecule p These coreceptors interact I conservedparts
D8 Dimeric Dean or CDsxp
of Mac and enhanceTCRengagement e
p MHCcomplex on Apcs
cytoplasmicdomain has eckdockingsite
Srofamilyproteintyrosinekinase 4
Activation markers Memory Age
CD69 is expressed first
Followed
3 CD25
followed
d cog
Gg
experiencedeffecto
by by
transient ILER or canbe Mostpersistent expression
expressedalone
CD24 Heat stableAg turned off when intrathymic matronis complete
Growthfactorreceptors
0 IL 2 114 important for maturecells
complete 112 714 receptors aren't needed formostaspects
of Tcell development
Ict crucial for initial expansion of Tale precursors at earlystages
T cell development
ofindespensible for Toysdevelopment
kit Receptor for stem cell factor Kitligand steelFactor supplements
ILIR furn is necessary for early T cell development
Effector Response Molecules
Tu cellsmake their 1stAgresponsebyturning on Ice expression
Tu respond to actionby expressing granzymes A B Ien Z
Tal Cells express TNFx IF Nic lowlevelsof granzymet
Thzcells It majorly 205 243 minor
0 NKTcells IFNI t 714 transcriptionFactor PLZ
go on
, TOPICS
A Majorstages of intrathymic development
10 TCRapRearrangement selectioncheckpoints
201 TCR based lineage diversification for xp T cells
3 Negative selection autoreactive cells
of 43T
B Anatomical organism
of T cell development
1 checkpoint controlled migration pathways
2 Inductive selective signals
fromthymus
CI B selection Response a Tcr dependent checkpoint
A.) Major Stages of Intrathymic Development
D IS selection programme
E Positive us Negative Tcr selection
4 Timing Anatomical sites
2.1 Role of signalstrength signal Quality
3 Anatomical differences in Agpresent
F CDA CDOlineage choice positive selection
d Major models
kinetic signalling model
3 CDAspecific drivers Th Pok GATA3
4 CDO specific driver Runx3
5 Signal DurationDependent lineage choice
G Negative selection
C Role of medulla
2 Treg selection as Alternative fate
µ Innate type Lymphocytes
Hematopoietic stem cells gain Lineage specificcharacteristics
Functionalplasticity
Diff effectorsubtypes
Major Landmarks Repertoire selection checkpoints
to eliminate non functional or selfreactiveTors
TCR x Ry V J recombination
V D J recombination
p es
D4 Linear monomeric Igstmolecule p These coreceptors interact I conservedparts
D8 Dimeric Dean or CDsxp
of Mac and enhanceTCRengagement e
p MHCcomplex on Apcs
cytoplasmicdomain has eckdockingsite
Srofamilyproteintyrosinekinase 4
Activation markers Memory Age
CD69 is expressed first
Followed
3 CD25
followed
d cog
Gg
experiencedeffecto
by by
transient ILER or canbe Mostpersistent expression
expressedalone
CD24 Heat stableAg turned off when intrathymic matronis complete
Growthfactorreceptors
0 IL 2 114 important for maturecells
complete 112 714 receptors aren't needed formostaspects
of Tcell development
Ict crucial for initial expansion of Tale precursors at earlystages
T cell development
ofindespensible for Toysdevelopment
kit Receptor for stem cell factor Kitligand steelFactor supplements
ILIR furn is necessary for early T cell development
Effector Response Molecules
Tu cellsmake their 1stAgresponsebyturning on Ice expression
Tu respond to actionby expressing granzymes A B Ien Z
Tal Cells express TNFx IF Nic lowlevelsof granzymet
Thzcells It majorly 205 243 minor
0 NKTcells IFNI t 714 transcriptionFactor PLZ
go on
, TOPICS
A Majorstages of intrathymic development
10 TCRapRearrangement selectioncheckpoints
201 TCR based lineage diversification for xp T cells
3 Negative selection autoreactive cells
of 43T
B Anatomical organism
of T cell development
1 checkpoint controlled migration pathways
2 Inductive selective signals
fromthymus
CI B selection Response a Tcr dependent checkpoint
A.) Major Stages of Intrathymic Development
D IS selection programme
E Positive us Negative Tcr selection
4 Timing Anatomical sites
2.1 Role of signalstrength signal Quality
3 Anatomical differences in Agpresent
F CDA CDOlineage choice positive selection
d Major models
kinetic signalling model
3 CDAspecific drivers Th Pok GATA3
4 CDO specific driver Runx3
5 Signal DurationDependent lineage choice
G Negative selection
C Role of medulla
2 Treg selection as Alternative fate
µ Innate type Lymphocytes
