IMMUNO
P AT H O L O G Y
,IMMUNOPATHOLOGY
10 warning signs of immune deficiency
,IMMUNE DEFICIENCY DSES
• a.ka. Immunodeficiency dses
• Defect or impairment in immune fxn
• Can be induced through infxns and various environmental factors
• Primary IDD: usually congenital, resulting from genetic defects in
some components of the immune system
• Secondary IDD: acquired, as a result of other dses or conditions such
as: HIV infxn, malnutrition, immunosuppression
, IMMUNOPATHOLOGY
1. Hypersensitivity reactions 5. Congenital complement deficiencies
a. Anaphylactic a. C1, C2, C4 deficiencies
b. Cytotoxic b. C5, C6, C7, C8 deficiencies
c. Immune complex-mediated c. Factor I and Factor H
d. Delayed deficiencies
2. B cell deficiency d. C1 inhibitor effect
a. Bruton’s dse 6. Accessory cell dysfunction
b. Selective IgA deficiency a. Chronic granulomatous dse
3. T cell deficiency b. Chediak-Higashi syndrome
a. DiGeorge syndrome 7. Miscellaneous
b. Nezelof syndrome a. Sarcoidosis
c. Hodgkin’s disease 8. Immunoproliferative disease
4. Combined B and T cell deficiencies a. Multiple myeloma
a. Ataxia telangiectasia b. Franklin’s dse
b. Wiskott-Aldrich syndrome
P AT H O L O G Y
,IMMUNOPATHOLOGY
10 warning signs of immune deficiency
,IMMUNE DEFICIENCY DSES
• a.ka. Immunodeficiency dses
• Defect or impairment in immune fxn
• Can be induced through infxns and various environmental factors
• Primary IDD: usually congenital, resulting from genetic defects in
some components of the immune system
• Secondary IDD: acquired, as a result of other dses or conditions such
as: HIV infxn, malnutrition, immunosuppression
, IMMUNOPATHOLOGY
1. Hypersensitivity reactions 5. Congenital complement deficiencies
a. Anaphylactic a. C1, C2, C4 deficiencies
b. Cytotoxic b. C5, C6, C7, C8 deficiencies
c. Immune complex-mediated c. Factor I and Factor H
d. Delayed deficiencies
2. B cell deficiency d. C1 inhibitor effect
a. Bruton’s dse 6. Accessory cell dysfunction
b. Selective IgA deficiency a. Chronic granulomatous dse
3. T cell deficiency b. Chediak-Higashi syndrome
a. DiGeorge syndrome 7. Miscellaneous
b. Nezelof syndrome a. Sarcoidosis
c. Hodgkin’s disease 8. Immunoproliferative disease
4. Combined B and T cell deficiencies a. Multiple myeloma
a. Ataxia telangiectasia b. Franklin’s dse
b. Wiskott-Aldrich syndrome
