Week 1 Case Study: Coagulation
BIOS-255: Anatomy & Physiology III w/ LB
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, 1. Discuss which clotting factors the PT and PTT test evaluate and whether each test
measures the intrinsic or the extrinsic pathways.
The Prothrombin Time (PT) Test is used to identify or diagnose blood coagulation disorders or
bleeding problems. Furthermore, there are a variety of reasons why this test is necessary. For
example, when a patient is scheduled for major surgery, it informs the physician if the blood is
clotting properly or if the patient is on warfarin (a blood thinner drug), among other things.
The Prothrombin Time Test is carrying out in a lab/ hospital by a lab technician. The blood is
obtaining from the venipuncture or fingertips and collected in a tube with sodium citrate to avoid
blood cells from the plasma. The plasma is then mixed with tissue factors to test the clotting
time. Thus, this will activate the extrinsic pathway of coagulation which will convert
Prothrombin to Thrombin. In addition, calcium is added to the mixture to counteract the sodium
citrate to allow coagulation to start. Hence, the time of coagulation, adding the calcium to the
time the plasma clot is known as Prothrombin Time.
What can be the Result?
The Prothrombin (PT) Test looks for the presence of the following factors: I (Fibrinogen), II
(Prothrombin), III (Prothrombin), IV (Prothrombin), V (Prothrombin), VI (Prothrombin
(Prothrombin). V, VII, and X are the last three letters of the alphabet. The Prothrombin time will
last around 9-12 seconds if the above factor is present, indicating that the patient has the normal
level of the above clotting factors. A prolonged Prothrombin Time Test will reveal a lack of
factors I, II, V, X, or VII. Liver disease, also known as vitamin K insufficiency. Also, if a patient
This study source was downloaded by 100000845689434 from CourseHero.com on 05 -12-2022 09:37:19 GMT -05:00
https://www.coursehero.com/file/109397136/Week-1-Case-Study-KIRBYdocx/
BIOS-255: Anatomy & Physiology III w/ LB
This study source was downloaded by 100000845689434 from CourseHero.com on 05 -12-2022 09:37:19 GMT -05:00
https://www.coursehero.com/file/109397136/Week-1-Case-Study-KIRBYdocx/
, 1. Discuss which clotting factors the PT and PTT test evaluate and whether each test
measures the intrinsic or the extrinsic pathways.
The Prothrombin Time (PT) Test is used to identify or diagnose blood coagulation disorders or
bleeding problems. Furthermore, there are a variety of reasons why this test is necessary. For
example, when a patient is scheduled for major surgery, it informs the physician if the blood is
clotting properly or if the patient is on warfarin (a blood thinner drug), among other things.
The Prothrombin Time Test is carrying out in a lab/ hospital by a lab technician. The blood is
obtaining from the venipuncture or fingertips and collected in a tube with sodium citrate to avoid
blood cells from the plasma. The plasma is then mixed with tissue factors to test the clotting
time. Thus, this will activate the extrinsic pathway of coagulation which will convert
Prothrombin to Thrombin. In addition, calcium is added to the mixture to counteract the sodium
citrate to allow coagulation to start. Hence, the time of coagulation, adding the calcium to the
time the plasma clot is known as Prothrombin Time.
What can be the Result?
The Prothrombin (PT) Test looks for the presence of the following factors: I (Fibrinogen), II
(Prothrombin), III (Prothrombin), IV (Prothrombin), V (Prothrombin), VI (Prothrombin
(Prothrombin). V, VII, and X are the last three letters of the alphabet. The Prothrombin time will
last around 9-12 seconds if the above factor is present, indicating that the patient has the normal
level of the above clotting factors. A prolonged Prothrombin Time Test will reveal a lack of
factors I, II, V, X, or VII. Liver disease, also known as vitamin K insufficiency. Also, if a patient
This study source was downloaded by 100000845689434 from CourseHero.com on 05 -12-2022 09:37:19 GMT -05:00
https://www.coursehero.com/file/109397136/Week-1-Case-Study-KIRBYdocx/
