BIOCHEMISTRY, GENETICS
& MOLECULAR BIOLOGY
2016 CATALOG
, Elsevier Science and Technology Books deliver targeted content that
enables the understanding and application of research. Year after year
readers use our books to drive advancements in their fields.
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Our Legacy Collection on ScienceDirect, in 20 subject areas, ensures that valuable
historical content is discoverable and searchable, saving time and resources.
, Table of Contents
Stay Connected Genetics...............................................................................2
Stay connected with
Molecular Biology............................................................. 19
Elsevier on Facebook,
Twitter, YouTube and Professional & Career Development................................42
LinkedIn. These sites
are full of news, resources, Serials................................................................................. 47
offers and discussions.
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other librarians,researchers,
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1
, Chromatin Signaling and Diseases
Edited by: Olivier Binda Principal Investigator, Newcastle Cancer Centre,
Northern Institute for Cancer Research, Newcastle University, Newcastle
upon Tyne, England
Martin Ernesto Fernandez-Zapico Associate Professor of Medicine,
Associate Professor Pharmacology, Mayo Institute, Rochester, MN, USA
Examining the molecular mechanisms that regulate gene expression to facilitate new drug
developments through targeting chromatin signaling mechanisms, this go-to reference reviews
the addition and removal of chemical modifications on histones, the proteins that specify them,
and the impact of gene expression defects associated with malfunctioning chromatin signaling
ISBN: 978-0-12-802389-1 KEY FEATURES
• Explains molecular mechanisms that regulate gene expression, which governs everything from
PUB DATE: June 2016
embryonic development, growth, and human pathologies associated with aging
FORMAT: Hardback • Educates clinicians and researchers about chromatin signaling, a molecular mechanism that is
PAGES: c. 390 changing our understanding of human pathology
AUDIENCE • Explores the addition and removal of chemical modifications on histones, the proteins that
geneticists, clinical researchers, life specifically recognize these, and the impact of gene expression defects associated with
malfunctioning chromatin signaling
science researchers, MD/clinicians
• Helps researchers learn about the quickly expanding field of chromatin signaling
who want to learn about epigenetics
and chromatin, cell biologists, DESCRIPTION
molecular biologists and Chromatin Signaling and Diseases covers the molecular mechanisms that regulate gene
biochemists
expression, which govern everything from embryonic development, growth, and human
pathologies associated with aging, such as cancer. This book helps researchers learn about or keep
up with the quickly expanding field of chromatin signaling.
After reading this book, clinicians will be more capable of explaining the mechanisms of gene
expression regulation to their patients to reassure them about new drug developments that target
chromatin signaling mechanisms. For example, several epigenetic drugs that act on chromatin
signaling factors are in clinical trials or even approved for usage in cancer treatments, Alzheimer's,
and Huntington's diseases. Other epigenetic drugs are in development to regulate various class of
chromatin signaling factors. To keep up with this changing landscape, clinicians and doctors will
need to stay familiar with genetic advances that translate to clinical practice, such as chromatin
signaling.
Although sequencing of the human genome was completed over a decade ago and its structure
investigated for nearly half a century, molecular mechanisms that regulate gene expression remain
largely misunderstood. An emerging concept called chromatin signaling proposes that small
protein domains recognize chemical modifications on the genome scaffolding histone proteins,
facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down
the access to genetic information, thereby regulating gene expression. The addition and removal
of chemical modifications on histones, as well as the proteins that specifically recognize these, is
reviewed in Chromatin Signaling and Diseases. Finally, the impact of gene expression defects
associated with malfunctioning chromatin signaling is also explored.
LIFE SCIENCES
GENETICS
2 Please contact your Elsevier Sales or Customer Service Representative
& MOLECULAR BIOLOGY
2016 CATALOG
, Elsevier Science and Technology Books deliver targeted content that
enables the understanding and application of research. Year after year
readers use our books to drive advancements in their fields.
Tools and content on ScienceDirect offer:
• Full-text version online or • Portable content available on
download and print with no computers, tablets and smartphones
digital rights management to give users information in the
restrictions (DRM) format that best suits their needs
• Multi-user/concurrent • Integrated book and journal
access at any time from any content for easier access to related
location to expand the reach materials
of the content to your patrons • Free MARC records to drive
discoverability and usage
Our foundational content—including
Reference Modules, unique
resources that are trustworthy,
current, discoverable, and hosted
on ScienceDirect—complements
original research in journal articles.
Our Legacy Collection on ScienceDirect, in 20 subject areas, ensures that valuable
historical content is discoverable and searchable, saving time and resources.
, Table of Contents
Stay Connected Genetics...............................................................................2
Stay connected with
Molecular Biology............................................................. 19
Elsevier on Facebook,
Twitter, YouTube and Professional & Career Development................................42
LinkedIn. These sites
are full of news, resources, Serials................................................................................. 47
offers and discussions.
Communicate with us and Titles Index...................................................................... 102
other librarians,researchers,
and professionals in Sales Representatives Index...........................................107
your field.View all at
Elsevier Books Customer Service Contacts....................112
store.elsevier.com/stayconnected
Imprints............................................................................113
Pricing
Publication dates, prices,
and other details subject to
change without notice.
virtuale.elsevier.com
1
, Chromatin Signaling and Diseases
Edited by: Olivier Binda Principal Investigator, Newcastle Cancer Centre,
Northern Institute for Cancer Research, Newcastle University, Newcastle
upon Tyne, England
Martin Ernesto Fernandez-Zapico Associate Professor of Medicine,
Associate Professor Pharmacology, Mayo Institute, Rochester, MN, USA
Examining the molecular mechanisms that regulate gene expression to facilitate new drug
developments through targeting chromatin signaling mechanisms, this go-to reference reviews
the addition and removal of chemical modifications on histones, the proteins that specify them,
and the impact of gene expression defects associated with malfunctioning chromatin signaling
ISBN: 978-0-12-802389-1 KEY FEATURES
• Explains molecular mechanisms that regulate gene expression, which governs everything from
PUB DATE: June 2016
embryonic development, growth, and human pathologies associated with aging
FORMAT: Hardback • Educates clinicians and researchers about chromatin signaling, a molecular mechanism that is
PAGES: c. 390 changing our understanding of human pathology
AUDIENCE • Explores the addition and removal of chemical modifications on histones, the proteins that
geneticists, clinical researchers, life specifically recognize these, and the impact of gene expression defects associated with
malfunctioning chromatin signaling
science researchers, MD/clinicians
• Helps researchers learn about the quickly expanding field of chromatin signaling
who want to learn about epigenetics
and chromatin, cell biologists, DESCRIPTION
molecular biologists and Chromatin Signaling and Diseases covers the molecular mechanisms that regulate gene
biochemists
expression, which govern everything from embryonic development, growth, and human
pathologies associated with aging, such as cancer. This book helps researchers learn about or keep
up with the quickly expanding field of chromatin signaling.
After reading this book, clinicians will be more capable of explaining the mechanisms of gene
expression regulation to their patients to reassure them about new drug developments that target
chromatin signaling mechanisms. For example, several epigenetic drugs that act on chromatin
signaling factors are in clinical trials or even approved for usage in cancer treatments, Alzheimer's,
and Huntington's diseases. Other epigenetic drugs are in development to regulate various class of
chromatin signaling factors. To keep up with this changing landscape, clinicians and doctors will
need to stay familiar with genetic advances that translate to clinical practice, such as chromatin
signaling.
Although sequencing of the human genome was completed over a decade ago and its structure
investigated for nearly half a century, molecular mechanisms that regulate gene expression remain
largely misunderstood. An emerging concept called chromatin signaling proposes that small
protein domains recognize chemical modifications on the genome scaffolding histone proteins,
facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down
the access to genetic information, thereby regulating gene expression. The addition and removal
of chemical modifications on histones, as well as the proteins that specifically recognize these, is
reviewed in Chromatin Signaling and Diseases. Finally, the impact of gene expression defects
associated with malfunctioning chromatin signaling is also explored.
LIFE SCIENCES
GENETICS
2 Please contact your Elsevier Sales or Customer Service Representative
