C785 Final Exam Questions & Answers
Which mRNA sequence results in a polypeptide that contains three amino
acids?
Correct Ans:-5' - CUU GAU ACU UAG - 3'
Which RNA sequence would end in the following polypeptide?
Phe-Thr-Val-Stop
Correct Ans:-5' - UUC ACA GUA UAA - 3'
What is the complementary sequence for the following DNA sequence?
5' - GCC ATC TCG AAT - 3'
Correct Ans:-5' - ATT CGA GAT GGC - 3'
Assuming 100% reaction efficiency, how many DNA copies are created after
the completion of four complete PCR cycles?
Correct Ans:-16
What is the function of DNA polymerase in the process of PCR?
Correct Ans:-It recognizes the primers and uses the available dNTPs to
replicate the template DNA sequence.
5' - [...] ATT CGC TAG GGC [...] - 3' − Normal DNA
5' - [...] ATT CGC GAG GGC [...] - 3' − Mutant DNA
Which type of mutation and outcome characterizes the Mutant DNA?
Correct Ans:-A missense mutation leading to a longer protein
In sickle-cell disease, the glutamic acid (Glu) at position number seven is
mutated to valine (Val).
What change in codons corresponds to this mutation?
Correct Ans:-GAA to GTA
What are possible blood types of the parents of a patient with blood type AB?
Correct Ans:-A and B
Which pair of chromosomes accurately depicts the genotype of a person with
an autosomal recessive mutant HBB allele and sickle cell anemia?
Correct Ans:-option 3- 2 mutant genes on chromosome 11
Which pair of chromosomes accurately depicts the genotype of a person with
an X-linked recessive mutant ALAS2 allele and sideroblastic anemia?
Correct Ans:-option 3, mutated allele
, Studies have shown that increased expression of two genes called SIRT1 and
SIRT2 is associated with chronic exposure to cocaine and contributes to drug
addiction. What difference in the regions of the SIRT1 and SIRT2 genes in
people addicted to cocaine increases their expression?
Correct Ans:-The nucleosomes become more widely spaced.
Mice with low levels of agouti gene expression tend to have yellow fur and
are obese, while mice with higher levels of expression are brown and of
normal weight. Studies show that expression of the agouti gene in mice can
be controlled by epigenetics. Mice with low levels of agouti gene expression
tend to have yellow fur and are obese, while mice with higher levels of
expression are brown and of normal weight. Studies show that expression of
the agouti gene in mice can be controlled by epigenetics. What scenario
describes epigenetic regulation of the agouti gene?
Correct Ans:-Mother mice fed methyl-rich diets during pregnancy give birth
to offspring with decreased agouti gene expression compared to those fed a
methyl-poor diet.
Oxidative damage to DNA can often result in the alteration of a single
nucleotide. Which DNA repair mechanism would repair this type of damage?
Correct Ans:-Base excision repair
Xeroderma pigmentosum (XP) is a recessive genetic disease that occurs
when one or more of the genes that perform nucleotide excision repair are
nonfunctional. Why do XP patients have a much higher incidence of skin
cancer than the general population?
Correct Ans:-The mutation rate of all other genes is higher due to failure to
repair.
Which reaction is responsible for the formation of polypeptides?
Correct Ans:-Dehydration
Which portion of the amino acid is inside the box?
Correct Ans:-Carboxyl group
Which amino acid side group is polar?
Correct Ans:-option 2-one with charge
When placed within a polypeptide chain, which amino acid would interact
most favorably with nonpolar amino acids?
Correct Ans:-option 2-non polar
Which term describes the order of amino acids in a peptide chain?
Correct Ans:-Primary structure
Which mRNA sequence results in a polypeptide that contains three amino
acids?
Correct Ans:-5' - CUU GAU ACU UAG - 3'
Which RNA sequence would end in the following polypeptide?
Phe-Thr-Val-Stop
Correct Ans:-5' - UUC ACA GUA UAA - 3'
What is the complementary sequence for the following DNA sequence?
5' - GCC ATC TCG AAT - 3'
Correct Ans:-5' - ATT CGA GAT GGC - 3'
Assuming 100% reaction efficiency, how many DNA copies are created after
the completion of four complete PCR cycles?
Correct Ans:-16
What is the function of DNA polymerase in the process of PCR?
Correct Ans:-It recognizes the primers and uses the available dNTPs to
replicate the template DNA sequence.
5' - [...] ATT CGC TAG GGC [...] - 3' − Normal DNA
5' - [...] ATT CGC GAG GGC [...] - 3' − Mutant DNA
Which type of mutation and outcome characterizes the Mutant DNA?
Correct Ans:-A missense mutation leading to a longer protein
In sickle-cell disease, the glutamic acid (Glu) at position number seven is
mutated to valine (Val).
What change in codons corresponds to this mutation?
Correct Ans:-GAA to GTA
What are possible blood types of the parents of a patient with blood type AB?
Correct Ans:-A and B
Which pair of chromosomes accurately depicts the genotype of a person with
an autosomal recessive mutant HBB allele and sickle cell anemia?
Correct Ans:-option 3- 2 mutant genes on chromosome 11
Which pair of chromosomes accurately depicts the genotype of a person with
an X-linked recessive mutant ALAS2 allele and sideroblastic anemia?
Correct Ans:-option 3, mutated allele
, Studies have shown that increased expression of two genes called SIRT1 and
SIRT2 is associated with chronic exposure to cocaine and contributes to drug
addiction. What difference in the regions of the SIRT1 and SIRT2 genes in
people addicted to cocaine increases their expression?
Correct Ans:-The nucleosomes become more widely spaced.
Mice with low levels of agouti gene expression tend to have yellow fur and
are obese, while mice with higher levels of expression are brown and of
normal weight. Studies show that expression of the agouti gene in mice can
be controlled by epigenetics. Mice with low levels of agouti gene expression
tend to have yellow fur and are obese, while mice with higher levels of
expression are brown and of normal weight. Studies show that expression of
the agouti gene in mice can be controlled by epigenetics. What scenario
describes epigenetic regulation of the agouti gene?
Correct Ans:-Mother mice fed methyl-rich diets during pregnancy give birth
to offspring with decreased agouti gene expression compared to those fed a
methyl-poor diet.
Oxidative damage to DNA can often result in the alteration of a single
nucleotide. Which DNA repair mechanism would repair this type of damage?
Correct Ans:-Base excision repair
Xeroderma pigmentosum (XP) is a recessive genetic disease that occurs
when one or more of the genes that perform nucleotide excision repair are
nonfunctional. Why do XP patients have a much higher incidence of skin
cancer than the general population?
Correct Ans:-The mutation rate of all other genes is higher due to failure to
repair.
Which reaction is responsible for the formation of polypeptides?
Correct Ans:-Dehydration
Which portion of the amino acid is inside the box?
Correct Ans:-Carboxyl group
Which amino acid side group is polar?
Correct Ans:-option 2-one with charge
When placed within a polypeptide chain, which amino acid would interact
most favorably with nonpolar amino acids?
Correct Ans:-option 2-non polar
Which term describes the order of amino acids in a peptide chain?
Correct Ans:-Primary structure
