WGU C785 Biochemistry Module 3&4
Questions And Answers
2,3-BPG stabilizes which state of hemoglobin?
Correct Ans: T state
2,3-BPG stabilizes the T state of hemoglobin. This reduces hemoglobin
affinity for __________ and promotes O2 ________to the tissues
Correct Ans: O2, released
CO stabilizes which state of hemoglobin?
Correct Ans: R state
When CO binds to the site at the iron hemoglobin it changes that heme's
____________
Correct Ans: shape and changes into the R state
H+(protons) stabilizes which state of hemoglobin?
Correct Ans: T state
At a lower pH of an actively metabolizing tissue, hemoglobin has a __________
affinity for oxygen
Correct Ans: LOWER
Low O2, Low pH
Correct Ans:
1. High H+
2. High CO2
3. Acidic
4. T State - bent
5. Deoxygenated
High O2, high pH
Correct Ans:
1. Basic
2. hemoglobin binds to oxygen
3. planar R state
4. decreases the affinity for oxygen
Bohr effect
Correct Ans: 1. Carbon dioxide decreases hemoglobins affinity for oxygen
2. when H+ ions increase, ph decrease
3. when pH is low affinity for oxygen and releases oxygen
,Hemoglobin binds to the oxygen at a ___________
Correct Ans: High pH
Hemoglobin releases oxygen at a ______________
Correct Ans: Low pH
Myoglobin
Correct Ans:
1. stores oxygen
2. has a higher affinity for oxygen
3. has a tertiary structure
4. monomer - single polypeptide chain
Hemoglobin
Correct Ans:
1. transports oxygen
2. has 4 FE (II) atoms to bind 4 oxygen molecules
3. has tertiary structure
Hemoglobin can bind very tightly to oxygen in the
Correct Ans: lungs, where oxygen levels are high
Hemoglobin release oxygen in the tissues
Correct Ans: where these oxygen levels are decreased
Hemoglobin's cooperative binding behavior is influenced by binding
____________
Correct Ans: oxygen
Sigmoidal (s-shape)
Correct Ans: hemoglobin
Curve to the left
Correct Ans: equals a base
high affinity for oxygen
Curves to the right
Correct Ans: equals an acid
lower affinity for oxygen
Hyperbolic (sideways, u shape)
Correct Ans: myoglobin
Deoxygentated
Correct Ans: T state
, Oxygenated
Correct Ans: R state
Deoxyhemoglobin
Correct Ans: oxygen unbound, T state
T state, deoxygenated
Correct Ans:
1. low pH
2. low concentration of oxygen
3. high concentration of H+ (protons)
4. high concentration of CO2
5. heme is bent (non planar)
Myoglobin and Hemoglobin both binds
Correct Ans: oxygen via the heme group
Why does the subunit composition of hemoglobin make it an ideal candidate
to transport oxygen?
Correct Ans: Since hemoglobin has 4 subunits, it can transport four oxygen
molecules. Additionally, communication between the four subunits
(cooperativity) will ensure that all four subunits pick up and deliver oxygen.
Pulse oximeter
Correct Ans: measures the fraction of hemoglobin bound to oxygen by
measuring levels of oxygenated hemoglobin in blood using light absorption
Why would oxygen concentration (torr) decrease from the lungs to distal
tissues?
Correct Ans: The oxygen concentration decreases from the lungs to the distal
tissues because oxygen enters the body in the lungs and is consumed Iin the
tissues.
Why would oxygen concentration (torr) be so much higher in the lungs than
distal tissues?
Correct Ans: The oxygen concentration is higher in the lungs compared to
the distal tissues because oxygen enters our body and diffuses into the blood
in the lungs
Conditions favor T state
Correct Ans:
1. low pH
Questions And Answers
2,3-BPG stabilizes which state of hemoglobin?
Correct Ans: T state
2,3-BPG stabilizes the T state of hemoglobin. This reduces hemoglobin
affinity for __________ and promotes O2 ________to the tissues
Correct Ans: O2, released
CO stabilizes which state of hemoglobin?
Correct Ans: R state
When CO binds to the site at the iron hemoglobin it changes that heme's
____________
Correct Ans: shape and changes into the R state
H+(protons) stabilizes which state of hemoglobin?
Correct Ans: T state
At a lower pH of an actively metabolizing tissue, hemoglobin has a __________
affinity for oxygen
Correct Ans: LOWER
Low O2, Low pH
Correct Ans:
1. High H+
2. High CO2
3. Acidic
4. T State - bent
5. Deoxygenated
High O2, high pH
Correct Ans:
1. Basic
2. hemoglobin binds to oxygen
3. planar R state
4. decreases the affinity for oxygen
Bohr effect
Correct Ans: 1. Carbon dioxide decreases hemoglobins affinity for oxygen
2. when H+ ions increase, ph decrease
3. when pH is low affinity for oxygen and releases oxygen
,Hemoglobin binds to the oxygen at a ___________
Correct Ans: High pH
Hemoglobin releases oxygen at a ______________
Correct Ans: Low pH
Myoglobin
Correct Ans:
1. stores oxygen
2. has a higher affinity for oxygen
3. has a tertiary structure
4. monomer - single polypeptide chain
Hemoglobin
Correct Ans:
1. transports oxygen
2. has 4 FE (II) atoms to bind 4 oxygen molecules
3. has tertiary structure
Hemoglobin can bind very tightly to oxygen in the
Correct Ans: lungs, where oxygen levels are high
Hemoglobin release oxygen in the tissues
Correct Ans: where these oxygen levels are decreased
Hemoglobin's cooperative binding behavior is influenced by binding
____________
Correct Ans: oxygen
Sigmoidal (s-shape)
Correct Ans: hemoglobin
Curve to the left
Correct Ans: equals a base
high affinity for oxygen
Curves to the right
Correct Ans: equals an acid
lower affinity for oxygen
Hyperbolic (sideways, u shape)
Correct Ans: myoglobin
Deoxygentated
Correct Ans: T state
, Oxygenated
Correct Ans: R state
Deoxyhemoglobin
Correct Ans: oxygen unbound, T state
T state, deoxygenated
Correct Ans:
1. low pH
2. low concentration of oxygen
3. high concentration of H+ (protons)
4. high concentration of CO2
5. heme is bent (non planar)
Myoglobin and Hemoglobin both binds
Correct Ans: oxygen via the heme group
Why does the subunit composition of hemoglobin make it an ideal candidate
to transport oxygen?
Correct Ans: Since hemoglobin has 4 subunits, it can transport four oxygen
molecules. Additionally, communication between the four subunits
(cooperativity) will ensure that all four subunits pick up and deliver oxygen.
Pulse oximeter
Correct Ans: measures the fraction of hemoglobin bound to oxygen by
measuring levels of oxygenated hemoglobin in blood using light absorption
Why would oxygen concentration (torr) decrease from the lungs to distal
tissues?
Correct Ans: The oxygen concentration decreases from the lungs to the distal
tissues because oxygen enters the body in the lungs and is consumed Iin the
tissues.
Why would oxygen concentration (torr) be so much higher in the lungs than
distal tissues?
Correct Ans: The oxygen concentration is higher in the lungs compared to
the distal tissues because oxygen enters our body and diffuses into the blood
in the lungs
Conditions favor T state
Correct Ans:
1. low pH
