BIOCHEM 551 Quiz 1 Re-Updated- Louisiana University

 Question 1
1.5 out of 1.5 points
A 55 year old woman with Type I DM is developing cataracts and presents to the ophthalmologist with the
following lab results;
Fasting blood glucose – High
Hemoglobin A1c – High
Urine ketones – positive
Urine glucose – positive
Which of these enzymes is most strongly associated with the development of cataracts?


Selected Answer: Aldose
reductase
 Question 2
1.5 out of 1.5 points
You are working in a cell biology lab with samples got from lysing a group of cell and you forgot to label the
samples. You can be certain one of the samples is not mitochondrial if it contains;


Selected Answer: Glucose 6-phosphatase
 Question 3
1.5 out of 1.5 points
The quarterback of the liberty flames just gone done with his vigorous early morning workout and just had
breakfast – cereal, scrambled eggs, pancakes with maple syrup, doughnuts and coffee with cream and sugar.
Which of these proteins will be inactive in his body now?


Selected Answer: PFK-2
 Question 4
1.5 out of 1.5 points
In a patient recently diagnosed with PDC deficiency, which of these nutritional propositions will give a
biochemical advantage to alleviate the patient’s symptoms;


Selected Answer: High fat, low carbohydrate diet
 Question 5
1.5 out of 1.5 points
In PDC deficiency, the brain is most significantly insulted because;


Selected Answer: It is unable to extract energy from
glucose
 Question 6
1.5 out of 1.5 points
In a patient who just consumed 3 cans of an alcoholic drink, which of these is most likely to result;


Selected Answer: Increased NADH
levels
 Question 7
0 out of 1.5 points
In the well-fed state, hepatocytes get meet their energy needs by;


Selected Answer: Lipolysis
 Question 8

, 1.5 out of 1.5 points
Milrinone is a phosphodiesterase inhibitor used to improve cardiac output in patients with heart failure. It works
by increasing intracellular levels of cAMP, which of these is a likely effect of milrinone on glucose metabolism?


Selected Answer: Increased glycogenolysis
 Question 9
1.5 out of 1.5 points
A defect in the gene that codes for pyruvate dehydrogenase phosphatase will cause;


Selected Answer: Depressed PDH activity
 Question 10
0 out of 1.5 points
You are evaluating a patient with recurrent seizures with a blood glucose of 50mg/dl(hypoglycemia), you should
avoid giving him a drug with this mechanism of action;


Selected Answer: Increases adenylate cyclase activity
 Question 11
1.5 out of 1.5 points
A 15 year old boy is diagnosed with McArdle's disease - a condition characterized by a deficiency of
muscle phosphorylase. Which of these findings is an uncommon feature of this condition?


Selected Answer: Recurrent hypoglycemia
 Question 12
1.5 out of 1.5 points
Which of these biochemical markers is a reliable indicator of a diabetic patient’s blood glucose control over the
past 90 - 120 days?


Selected Answer: Elevated HbA1c
 Question 13
1.5 out of 1.5 points
A 55 yr old alcoholic was brought to the Ed passed out, he is given IV thiamine and glucose. The next day he is
alert and his serum thiamine level is normal and his blood glucose is 7.5mmol/L (3.5 -5 mmol/L) and he is
discharged. At the time of his discharge, which of these proteins will have no significant activity?

Selected Answer: Pyruvate carboxylase
 Question 14
1.5 out of 1.5 points
In a patient diagnosed with an E3 subunit mutation form of PDC deficiency, which of these is an expected
biochemical finding?


Selected Answer: All of these
 Question 15
1.5 out of 1.5 points
Due to the absence of PDC activity, patients are unable to ;


Selected Answer: Produce acetyl CoA from pyruvate
 Question 16
1.5 out of 1.5 points

, This supplement will be beneficial to the activity of PDC;


Selected Answer: All of these
 Question 17
1.5 out of 1.5 points
The glycolytic intermediate that can be used for fatty acid biosynthesis is;


Selected Answer: DHAP
 Question 18
1.5 out of 1.5 points
Which of these gluconeogenic substrates is formed by oxidizing odd-chain fatty acids?


Selected Answer: Propionyl-CoA
 Question 19
1.5 out of 1.5 points
You are working as a pediatrician on call and you have been sent a consult about a 2 hour old infant of a
diabetic mother. Because the mother's blood glucose was poorly controlled during her pregnancy, which of
these is an expected finding in the baby's lab work?

Selected Answer: Elevated insulin level
 Question 20
1.5 out of 1.5 points
A severe and life-threatening complication of PDC deficiency is;


Selected Answer: Lactic acidosis
 Question 21
1.5 out of 1.5 points
A direct consequence of decreased PDC activity is that patients are unable to;


Selected Answer: Produce acetyl-CoA from pyruvate
 Question 22
1.5 out of 1.5 points
You are managing a patient who is prone to recurrent hypoglycemia, which of these will be least useful in
helping the patient maintain a steady blood glucose level?

Selected Answer: Lysine
 Question 23
1.5 out of 1.5 points
Which of these enzyme deficiencies will most likely cause a cataract;


Selected Answer: Gal 1-phosphate uridyltransferase
deficiency
 Question 24
0 out of 1.5 points
Sildenafil is a phosphodiesterase inhibitor used to improve cardiac output in patients with heart failure. It works
by increasing intracellular levels of cAMP, which of these is a likely effect of sildenafil on glucose metabolism?