BIOCHEM 551 Quiz 3 Re-Updated- Louisiana University

 Question 1
1.5 out of 1.5 points
Patients with Type II DM due to insulin resistance tend to also have Type IV hypertriglyceridemia possibly as a result of __________?



Selected Decrease lipoprotein lipase activity
Answer:


 Question 2
1.5 out of 1.5 points
Which of these statements about Proprotein convertase subtilisin/kexin-9 (PCSK-9) is most accurate?

Selected Antibodies that block the action of PCSK-9 will reduce plasma LDL levels
Answer:

 Question 3
0 out of 1.5 points
The production of apoB-48 from the full-length apoB100 gene is accomplished by the enzyme _____________ which produces
deoxyuracil at position 6666 of the apoB mRNA resulting in a stop codon?



Selected Answer: Cytosine deaminase (apobec-1)
in hepatocytes

Correct answer is: cytosine deaminase (apobec-1) in
enterocytes

 Question 4
0 out of 1.5 points
Microsomal triglyceride transfer protein plays a major role in lipoprotein assembly by which of these mechanisms?



Selected Answer: Facilitating the transfer of lipids
from the membrane to nascent
aopB


Also not: Facilitating the import of triglycerides into
the ER for lipoprotein assembly
 Question 5
1.5 out of 1.5 points
Lipoprotein lipase on the capillaries of adipose tissues is activated by what component
of VLDLs?


Selected Apo C-
Answer: II

 Question 6
1.5 out of 1.5 points
Chylomicron retention disease is a genetic disorder characterized by a malabsorbtion of
dietary lipids, fatty stool, accumulation of intestinal triglycerides and
hypolipoproteinemia. A deficiency of which apoprotein is most likely responsible for this

, disorder?


Selected Apo B-
Answer: 48

 Question 7
1.5 out of 1.5 points
Which of these has the greatest affinity for LDL receptors?


Selected apo
Answer: E

 Question 8
1.5 out of 1.5 points
Which of these is not consistent with a case of Familial hypercholesterolemia?


Selected Decreased
Answer: HDL

 Question 9
1.5 out of 1.5 points
Which of these is not a function of cholesterol?


Selected Albumin
Answer: synthesis

 Question 10
1.5 out of 1.5 points
Chylomicron retention disease is a genetic disorder characterized by a malabsorption of
dietary lipids, fatty stool, accumulation of intestinal triglycerides and
hypolipoproteinemia. A deficiency of which apoprotein is most likely responsible for this
disorder?


Selected Apo B-
Answer: 48

 Question 11
1.5 out of 1.5 points
An increased transcriptional activity of SREBP will result in;


Selected Reduced serum
Answer: cholesterol levels

 Question 12
1.5 out of 1.5 points
Scavanger receptor 1(SR-1) is not usually found on which of these tissues?


Selected Kidne
Answer: ys

,  Question 13
1.5 out of 1.5 points
This hormone is present on adipose tissues, it is stimulated by insulin and breaks down
triglycerides carried by chylomicron, VLDL and IDL to extract the fatty acids and glycerol
for storage;


Selected Lipoprotein
Answer: Lipase

 Question 14
1.5 out of 1.5 points
A patient with a history of recurrent pancreatitis, eruptive xanthomas and increased
triglycerides associated with chylomicrons, most likely has a deficiency of __________?


Selected Lipoprotein
Answer: lipase

 Question 15
1.5 out of 1.5 points
Which is not true about chylomicrons?


Selected They are synthesized in
Answer: the liver

 Question 16
1.5 out of 1.5 points
The plasma HDL levels are low in these diseases except?


Selected Apo B-100
Answer: deficiency

 Question 17
1.5 out of 1.5 points
Triglycerides stored in adipose tissues are catabolized by HSL into fatty acids and
glycerol. What is the fate of the glycerol produced in the post-absorptive state?


Selected All of the
Answer: above

 Question 18
1.5 out of 1.5 points
Lipitor is an anti-hyperlipidemic drug used to reduce LDL levels by inhibiting HMG CoA
reductase. This enzyme is _________?


Selected Activated by
Answer: insulin

 Question 19
1.5 out of 1.5 points
A disease that usually presents with enlarged and orange-colored tonsils,
hypertriacylglerolemia, low LDL levels and a tendency to have atherosclerosis in the