MSN 571
Prescriptive authority - Answer legal authority granted to advanced practice nurses to
prescribe medication; DETERMINED BY STATE LAW
Rational Drug Selection - Answer based on individual patient and addresses disease
specific information: ONLY A GUIDELINE
Drug Selection - Answer includes analysis of cost, guidelines, avaibalbility, interactions,
side effects, allergies, hepatic and renal function, need for monitoring, special
precautions i.e elderly
medication education basic components - Answer medication name
purpose
dosing regimen
administration
adverse effects
any storage needs
associated labs testing
food & drug interactions
duration of therapy
medication adherence - Answer barriers to adherence=
forgetfulness
lack of planning
cost
dissatisfaction
altered dosing
Phamacokinetics - Answer study of drug movement throughout body
principles of pharmacokinetics - Answer absorption
distribution
metabolism
excretion
Passage of drugs across membranes - Answer - channels and pores
- transport systems (P-glycoprotein)
- direct penetration of the membrane
Absorption of drugs - Answer Transfer of drugs from site of administration across cell
membrane into the blood stream
factors that affect absorption of drugs - Answer rate of dissolution- how easy dissolves
surface area- >surface area moves faster
blood flow- >blood flow moves faster
lipid solubility - lipid easily cross membrane
ph partitioning -
, MSN 571
Distribution of drugs - Answer movement of drugs from systemic circulation to site of
drug action
factors that determine drug flow - Answer blood flow to tissues
ability to exit vascular system
ability to enter cell
Drug ability to exit vascular system - Answer capillary bed- typical
blood brain barreier
placenta drug transfer
protein binding - albumin
drug ability to enter cell - Answer binds with receptors on external surface of cell
membrane
drug metabolism - Answer the enzymatic biotransformation of a drug structure
most occur in liver by P450 system
first pass effect - Answer rapid hepatic inactivation of drug on its first pass through liver
drug excretion - Answer elimination of a drug from the body
Drug Excretion Routes - Answer renal
breast milk
bile
lungs
sweat
saliva
therapeutic drug range - Answer range of drug between minimum effective dose and
toxic dose. larger index - safer dose smaller index- harmful dose
drug half life - Answer the time required for the amount of drug in the body to decrease
by 50%
Phamacodynamics - Answer biochemical and physiological effects of drugs on body
dose-response relationship - Answer the relationship between the size of an
administered dose and the intensity it produces
Drug selectivity - Answer drug is effective in intended use w/out harmful effects but
causes undesired effects (<BP but > nausea)
ease of administration - Answer increases convenience and adherence and decreases
administration efforts
Prescriptive authority - Answer legal authority granted to advanced practice nurses to
prescribe medication; DETERMINED BY STATE LAW
Rational Drug Selection - Answer based on individual patient and addresses disease
specific information: ONLY A GUIDELINE
Drug Selection - Answer includes analysis of cost, guidelines, avaibalbility, interactions,
side effects, allergies, hepatic and renal function, need for monitoring, special
precautions i.e elderly
medication education basic components - Answer medication name
purpose
dosing regimen
administration
adverse effects
any storage needs
associated labs testing
food & drug interactions
duration of therapy
medication adherence - Answer barriers to adherence=
forgetfulness
lack of planning
cost
dissatisfaction
altered dosing
Phamacokinetics - Answer study of drug movement throughout body
principles of pharmacokinetics - Answer absorption
distribution
metabolism
excretion
Passage of drugs across membranes - Answer - channels and pores
- transport systems (P-glycoprotein)
- direct penetration of the membrane
Absorption of drugs - Answer Transfer of drugs from site of administration across cell
membrane into the blood stream
factors that affect absorption of drugs - Answer rate of dissolution- how easy dissolves
surface area- >surface area moves faster
blood flow- >blood flow moves faster
lipid solubility - lipid easily cross membrane
ph partitioning -
, MSN 571
Distribution of drugs - Answer movement of drugs from systemic circulation to site of
drug action
factors that determine drug flow - Answer blood flow to tissues
ability to exit vascular system
ability to enter cell
Drug ability to exit vascular system - Answer capillary bed- typical
blood brain barreier
placenta drug transfer
protein binding - albumin
drug ability to enter cell - Answer binds with receptors on external surface of cell
membrane
drug metabolism - Answer the enzymatic biotransformation of a drug structure
most occur in liver by P450 system
first pass effect - Answer rapid hepatic inactivation of drug on its first pass through liver
drug excretion - Answer elimination of a drug from the body
Drug Excretion Routes - Answer renal
breast milk
bile
lungs
sweat
saliva
therapeutic drug range - Answer range of drug between minimum effective dose and
toxic dose. larger index - safer dose smaller index- harmful dose
drug half life - Answer the time required for the amount of drug in the body to decrease
by 50%
Phamacodynamics - Answer biochemical and physiological effects of drugs on body
dose-response relationship - Answer the relationship between the size of an
administered dose and the intensity it produces
Drug selectivity - Answer drug is effective in intended use w/out harmful effects but
causes undesired effects (<BP but > nausea)
ease of administration - Answer increases convenience and adherence and decreases
administration efforts
