CEREBROSPINAL
FLUID
CHAPTER 10
,FORMATION AND PHYSIOLOGY
• Brain and spinal cord lined by meninges
• Three layers of meninges
• Dura mater: outer
• Arachnoid: middle
• Pia mater: surfaces of brain and spinal cord
• Cerebrospinal fluid (CSF) produced in choroid plexuses of
the four ventricles from plasma
• 20 mL/min produced in adults
• Volume adults 90-150 mL, neonates 10-60 mL
,
, FORMATION AND PHYSIOLOGY (CONT’D)
• CSF flows through subarachnoid space between arachnoid
and pia mater
• Reabsorbed into blood in arachnoid granulations/villae
(one-way valves)
• Formation:
• Hydrostatic pressure and active transport
• Not an ultrafiltrate
• Very tight-fitting endothelial cells, prevent filtration of large
molecules – called the blood-brain barrier
FLUID
CHAPTER 10
,FORMATION AND PHYSIOLOGY
• Brain and spinal cord lined by meninges
• Three layers of meninges
• Dura mater: outer
• Arachnoid: middle
• Pia mater: surfaces of brain and spinal cord
• Cerebrospinal fluid (CSF) produced in choroid plexuses of
the four ventricles from plasma
• 20 mL/min produced in adults
• Volume adults 90-150 mL, neonates 10-60 mL
,
, FORMATION AND PHYSIOLOGY (CONT’D)
• CSF flows through subarachnoid space between arachnoid
and pia mater
• Reabsorbed into blood in arachnoid granulations/villae
(one-way valves)
• Formation:
• Hydrostatic pressure and active transport
• Not an ultrafiltrate
• Very tight-fitting endothelial cells, prevent filtration of large
molecules – called the blood-brain barrier
