what is a left shift?
***need to know per lecture*** Correct Answer: increased number of immature neutrophils AKA band
cells
what are bands in relation to a CBC? Correct Answer: young neutrophils
what does "more band building" mean? Correct Answer: more shift to the left, more young neutrophils
what is the first clue that an infection is starting? Correct Answer: shift to the left
what could cause a left shift?
***need to know per lecture*** Correct Answer: infection
physical stress
(ex: surgery)
inflammation
when reading labs, what does SEGS represent? Correct Answer: mature neutrophils
"segmental neutrophils"
what are thrombocytes? Correct Answer: platelets
what percentage of blood is plasma vs RBCs? Correct Answer: RBC 45%
plasma 55%
what are the three types of protein found in plasma? Correct Answer: albumin
(maintains blood volume and binds to substances)
globulins
(main proteins of antibodies)
fibrinogen
(activated by thrombin, forms fibrin clots)
,what can happen if a patient has low albumin? Correct Answer: leads to leaky vessels which can lead to
third spacing, edema
what can cause low albumin? Correct Answer: AKI
malnutrition
hemorrhage
burns
liver disease
hemoglobin vs hematocrit per lecture
***need to know per lecture*** Correct Answer: hematocrit measures the percentage of blood that is
RBCs
hemoglobin measures how many RBCs you have
hemoglobin protein carries oxygen - without sufficient hemoglobin, won't have enough oxygen
function and anatomy of the spleen Correct Answer: vascular and lymph tissues, located in ULQ of
abdomen
functions:
filters blood
stores blood and platelets
aids in antigen production
aids in initiation of B&T lymphocytes
white pulp: where immune functions occur
red pulp: where filtration occurs
can you live without your spleen? Correct Answer: yes, but will be at higher risk of infection
why do we need to assess/palpate the spleen for patients with sickle cell anemia? Correct Answer:
sickle cells can get stuck in the spleen and cause it to rupture - will have lots of pain with palpation
how long do normal RBCs live?
,which organ removes them from the blood? Correct Answer: 120 days
the spleen
the primary function of erythrocytes is __________
***need to know per lecture*** Correct Answer: respiration
what are the two pathways in the clotting cascade?
which one is faster? Correct Answer: intrinsic
(blood or vessel injury)
&
extrinsic
(external tissue damage)
extrinsic is faster, skips some steps in the clotting cascade
PT or PTT - which goes with intrinsic or extrinsic clotting cascade? Correct Answer: extrinsic monitored
by PT
intrinsic monitored by PTT
PT vs INR vs PTT
***need to know per lecture*** Correct Answer: PT measures how long it takes a clot to form
(we use to monitor oral anticoag therapy - warfarin/coumadin)
INR is used to standardize PT lab results
PTT evaluates all clotting factors of intrinsic pathway except platelets
(we use to monitor response to anticoag therapies - heparin)
what could increased INR indicate? Correct Answer: DIC
taking salicylates
, cirrhosis
hepatitis
vitamin K deficiency
what does high vs low INR mean? Correct Answer: high INR = takes a long time to clot = bleeding risk
low INR = clots fast = clot risk
what is a normal INR?
what do we want INR at for someone taking warfarin/coumadin? Correct Answer: normal is 1.1 or less
if on warfarin/coumadin, we want to be at 2-3
how long do platelets live? Correct Answer: 4-7 days
how long does aspirin affect blood clotting for? Correct Answer: it irreversibly inhibits platelet
aggregation for the entirety of a platelet's life, which is 4-7 days
what do we use bone marrow biopsy for vs a bone marrow aspiration?
***need to know per lecture*** Correct Answer: biopsy - diagnosis of leukemia
aspiration - check if treatment is working and/or look for bone marrow suppression
how can drinking alcohol cause/affect hematological issues? Correct Answer: 90% of alcohol is
metabolized in the liver and damage to the liver increases the risk for hematological problems
assessment considerations for hematological assessment Correct Answer: history:
nutrition
past medical hx
chronic disease
medications and herbs:
--- goldenseal and green tea can reduce the effect of anticoags
--- aspirin inhibits platelet aggregation
--- penicillins, cephalosporins, vancomycin may cause neutropenia
physical assessment
lab profile
examination of bone marrow