Pharmacology 310 Exam

Pharmacology 310 Midterm Exam_2020 1. Drug therapy during pregnancy • First trimester • Greatest danger of drug-induced developmental defects. • Last trimester • Most drug transfer to the fetus • 2. Problematic medications for the elderly. Why? 3. Factors affecting pediatric drug dosages • Skin is thinner • Stomach lacks of acid to kill bacteria • Lungs have weaker mucous barrier • Body temp is less regulated and dehydration occurs easily • Liver and kidney are immature 4. Physiologic changes in the elderly and consequences of the same 5. Main function of the liver and kidney • Liver- Metabolism (AST, ALT) • Kidney- Elimination (serum creatinine, BUN) 6. Safety in medication administration for the pediatric patient 7. Patient teaching and adverse effects - MAOIs, anti-cholinergic, COMT inhibitor • MAOIs o Avoid foods: cheese, red wine, beer, yogurt Rasagiline & Selegilin o Adverse effect: hypotension, diarrhea, confusion, dsykinesia • COMT Entacapone o Adverse effect: GI upset, dyskinesia, urine discoloration